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The map label for this gene is ptpA [H]

Identifier: 182677166

GI number: 182677166

Start: 197691

End: 198161

Strand: Direct

Name: ptpA [H]

Synonym: Bind_0166

Alternate gene names: 182677166

Gene position: 197691-198161 (Clockwise)

Preceding gene: 182677163

Following gene: 182677167

Centisome position: 4.74

GC content: 60.3

Gene sequence:

>471_bases
ATGTCCTCTCAAATCGCCGTTCTCTTCGTTTGCACAGGCAATATTTGCCGCTCGCCTCTCGCTGAAGCGGCCTTTCGGGA
AGAGATCATGCGCCTTGGCGTGTTGGCGCAGGTCGATTCCGCGGGCATCGGTGCCTGGCATATTGGTGATCCGCCCGATC
GGCGCGCGCAGGCGGTGGCGCGCCGTCATGGAATCGAGATCGGAGATTATCGCGCGCGGCAAGTCGAAAAGACGGATTTT
GAACATTTCACGCATGTGATTGCTTTGGACAACAGCCATCTCCGAGCGCTACGGCGTCTTTCTCCAGAGGGATCGCGCGC
GCAAACGAGCCTCTTGCTCGATCATGTTCCTGGCCGCGCCGGGCAGGATGTCGAAGATCCTTATTATGGGTCTGATGCCG
GTTTCGATCAGACGTGGCGAGATGTCGTGGAAGGGGCGGCGGGGCTGGCGCGAGGCCTGTGGAGGCGCTGA

Upstream 100 bases:

>100_bases
CAGATCAGACCCAAAAGTGGGAGCCACTTTTGGGTCTGATGCTCGAACCGATCGACAAGTCCTCAATGCCTTATCTTTTT
CTTCCACGGAAAATGTATCC

Downstream 100 bases:

>100_bases
ATGAATCCTCTCGCGGCGATTGCGGCGCGCTTGCTTGGCGTGGAGGTCCGTGCCGTTGAACCGGTCAGTGGTGGCGATCT
TTCGCAGGTTCTGCGTCTGA

Product: protein tyrosine phosphatase

Products: NA

Alternate protein names: PTPase; Small, acidic phosphotyrosine protein phosphatase; PY protein phosphatase [H]

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MSSQIAVLFVCTGNICRSPLAEAAFREEIMRLGVLAQVDSAGIGAWHIGDPPDRRAQAVARRHGIEIGDYRARQVEKTDF
EHFTHVIALDNSHLRALRRLSPEGSRAQTSLLLDHVPGRAGQDVEDPYYGSDAGFDQTWRDVVEGAAGLARGLWRR

Sequences:

>Translated_156_residues
MSSQIAVLFVCTGNICRSPLAEAAFREEIMRLGVLAQVDSAGIGAWHIGDPPDRRAQAVARRHGIEIGDYRARQVEKTDF
EHFTHVIALDNSHLRALRRLSPEGSRAQTSLLLDHVPGRAGQDVEDPYYGSDAGFDQTWRDVVEGAAGLARGLWRR
>Mature_155_residues
SSQIAVLFVCTGNICRSPLAEAAFREEIMRLGVLAQVDSAGIGAWHIGDPPDRRAQAVARRHGIEIGDYRARQVEKTDFE
HFTHVIALDNSHLRALRRLSPEGSRAQTSLLLDHVPGRAGQDVEDPYYGSDAGFDQTWRDVVEGAAGLARGLWRR

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=142, Percent_Identity=41.5492957746479, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI6005988, Length=142, Percent_Identity=39.4366197183099, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI96304457, Length=78, Percent_Identity=47.4358974358974, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325330, Length=145, Percent_Identity=31.7241379310345, Blast_Score=113, Evalue=1e-26,
Organism=Drosophila melanogaster, GI78706766, Length=147, Percent_Identity=36.734693877551, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI78706768, Length=147, Percent_Identity=36.734693877551, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI78706770, Length=142, Percent_Identity=41.5492957746479, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI78706772, Length=142, Percent_Identity=41.5492957746479, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI78706764, Length=124, Percent_Identity=39.5161290322581, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI78711846, Length=147, Percent_Identity=31.2925170068027, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648069, Length=91, Percent_Identity=36.2637362637363, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17247; Mature: 17115

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQIAVLFVCTGNICRSPLAEAAFREEIMRLGVLAQVDSAGIGAWHIGDPPDRRAQAVA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHH
RRHGIEIGDYRARQVEKTDFEHFTHVIALDNSHLRALRRLSPEGSRAQTSLLLDHVPGRA
HHHCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
GQDVEDPYYGSDAGFDQTWRDVVEGAAGLARGLWRR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSQIAVLFVCTGNICRSPLAEAAFREEIMRLGVLAQVDSAGIGAWHIGDPPDRRAQAVA
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHH
RRHGIEIGDYRARQVEKTDFEHFTHVIALDNSHLRALRRLSPEGSRAQTSLLLDHVPGRA
HHHCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
GQDVEDPYYGSDAGFDQTWRDVVEGAAGLARGLWRR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550407; 12000953 [H]