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The map label for this gene is cysK [H]

Identifier: 182682455

GI number: 182682455

Start: 2173158

End: 2174117

Strand: Direct

Name: cysK [H]

Synonym: XfasM23_1942

Alternate gene names: 182682455

Gene position: 2173158-2174117 (Clockwise)

Preceding gene: 182682454

Following gene: 182682456

Centisome position: 85.7

GC content: 58.65

Gene sequence:

>960_bases
ATGACTATCTACAACACTATCCTGGACACGATTGGCCACACACCCGTGGTTAAACTGAACCGCATTGCTCCGGCACACGT
GGATCTATACATCAAGGTTGAATCATTCAATCCAAGCGGCTCGGTCAAAGACCGTCTGGCACTGGCCATCATTCTCGACG
CCGAACAACAGGGGTTATTGAAACCCGGCGACACCATCGTCGAAGCCACTTCGGGAAATACCGGCGTCGCCCTGGCCATG
ATCGCCGCTGCCCGCGGCTACACGTTCGTCGCCACCATGGTCGAAACCTTTTCGATCGAGCGGCGCAAACTGATGCGCGC
TTACGGTGCCAAAGTCATCCTCACCCCAGCCGCCGAACGCGGTAGCGGCATGGTACGCAAAGCCAAAGAACTCGCCCAAC
AGCACGGCTGGTTCCTCGCCAGCCAATTTTCCAACCCAGCCAACCCTGCCTATCACCGCAACACCACCGCCGCGGAAATC
CTACGAGACTTTGCCGGACGCCGCCTCGACCACTTCGTCAGTGGATGGGGCACCGGCGGCACGCTTACTGGCGTTGGTGA
AGTACTGAAAATCGCGCGACCAGACATCAAAATCACCGCCAGCGAACCTGCCAGCGCAGCACTGCTCCAAGGGAAGGAAT
GGCAACCCCACAAGATTCAGGGATGGACACCCGATTTCGTACCGGAGGTACTGAATCGTTCCGTTCCACACCACATCCTC
AGTGTTACCGACGACGATGCAATCACGGTAGCCCGTCGCCTGGCCGCGGAGGAAGGTGTTTTCTCGGGGATCTCCGGCGG
TGCCTCCGTCGCAACAGCACTGCAGATCGCACAACAGGCCGAACCGGGTGCCGTGATCCTCGCCATGCTCCCAGATACCG
GCGAACGTTACTTCTCCACCCCTCTGTTCGCTGACATCAATGAGCATTCAGACGACGCGTGGTTAGCCAGTCTCGGCTGA

Upstream 100 bases:

>100_bases
TTATCTGCCCCATGCCCCCCACGCACGCATCCTATAAGCTGATTCAAAGACACACGTATCTGTGTGTACATCCTCCCCGA
TTACTTCCACAGAGACCTTC

Downstream 100 bases:

>100_bases
ACACAGCAGAATGTTCCTGAGCTGGCGCAGCGCAACACGCTCCACGGCCGATGTGTCCTCCATCGCACAACAAATGGACA
CGTCGCATGGACTCCACAGC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTIYNTILDTIGHTPVVKLNRIAPAHVDLYIKVESFNPSGSVKDRLALAIILDAEQQGLLKPGDTIVEATSGNTGVALAM
IAAARGYTFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAQQHGWFLASQFSNPANPAYHRNTTAAEI
LRDFAGRRLDHFVSGWGTGGTLTGVGEVLKIARPDIKITASEPASAALLQGKEWQPHKIQGWTPDFVPEVLNRSVPHHIL
SVTDDDAITVARRLAAEEGVFSGISGGASVATALQIAQQAEPGAVILAMLPDTGERYFSTPLFADINEHSDDAWLASLG

Sequences:

>Translated_319_residues
MTIYNTILDTIGHTPVVKLNRIAPAHVDLYIKVESFNPSGSVKDRLALAIILDAEQQGLLKPGDTIVEATSGNTGVALAM
IAAARGYTFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAQQHGWFLASQFSNPANPAYHRNTTAAEI
LRDFAGRRLDHFVSGWGTGGTLTGVGEVLKIARPDIKITASEPASAALLQGKEWQPHKIQGWTPDFVPEVLNRSVPHHIL
SVTDDDAITVARRLAAEEGVFSGISGGASVATALQIAQQAEPGAVILAMLPDTGERYFSTPLFADINEHSDDAWLASLG
>Mature_318_residues
TIYNTILDTIGHTPVVKLNRIAPAHVDLYIKVESFNPSGSVKDRLALAIILDAEQQGLLKPGDTIVEATSGNTGVALAMI
AAARGYTFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAQQHGWFLASQFSNPANPAYHRNTTAAEIL
RDFAGRRLDHFVSGWGTGGTLTGVGEVLKIARPDIKITASEPASAALLQGKEWQPHKIQGWTPDFVPEVLNRSVPHHILS
VTDDDAITVARRLAAEEGVFSGISGGASVATALQIAQQAEPGAVILAMLPDTGERYFSTPLFADINEHSDDAWLASLG

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=332, Percent_Identity=38.2530120481928, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI295821200, Length=332, Percent_Identity=38.2530120481928, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI4557415, Length=332, Percent_Identity=38.2530120481928, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI1788754, Length=308, Percent_Identity=47.7272727272727, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=42.156862745098, Blast_Score=233, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=42.483660130719, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17562970, Length=307, Percent_Identity=44.299674267101, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=43.8775510204082, Blast_Score=223, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=44.1176470588235, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=41.7218543046358, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32566672, Length=221, Percent_Identity=42.9864253393665, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17534315, Length=334, Percent_Identity=32.9341317365269, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=331, Percent_Identity=32.9305135951662, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17539800, Length=335, Percent_Identity=25.3731343283582, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=35.2941176470588, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539640, Length=349, Percent_Identity=26.3610315186246, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996324, Length=336, Percent_Identity=24.1071428571429, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=330, Percent_Identity=31.8181818181818, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=30.9309309309309, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24643623, Length=335, Percent_Identity=36.7164179104478, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI20129101, Length=335, Percent_Identity=36.7164179104478, Blast_Score=185, Evalue=4e-47,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34204; Mature: 34073

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIYNTILDTIGHTPVVKLNRIAPAHVDLYIKVESFNPSGSVKDRLALAIILDAEQQGLL
CCHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCC
KPGDTIVEATSGNTGVALAMIAAARGYTFVATMVETFSIERRKLMRAYGAKVILTPAAER
CCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
GSGMVRKAKELAQQHGWFLASQFSNPANPAYHRNTTAAEILRDFAGRRLDHFVSGWGTGG
CCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TLTGVGEVLKIARPDIKITASEPASAALLQGKEWQPHKIQGWTPDFVPEVLNRSVPHHIL
CHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEE
SVTDDDAITVARRLAAEEGVFSGISGGASVATALQIAQQAEPGAVILAMLPDTGERYFST
EECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCC
PLFADINEHSDDAWLASLG
CCEEECCCCCCCCEEECCC
>Mature Secondary Structure 
TIYNTILDTIGHTPVVKLNRIAPAHVDLYIKVESFNPSGSVKDRLALAIILDAEQQGLL
CHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCC
KPGDTIVEATSGNTGVALAMIAAARGYTFVATMVETFSIERRKLMRAYGAKVILTPAAER
CCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
GSGMVRKAKELAQQHGWFLASQFSNPANPAYHRNTTAAEILRDFAGRRLDHFVSGWGTGG
CCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TLTGVGEVLKIARPDIKITASEPASAALLQGKEWQPHKIQGWTPDFVPEVLNRSVPHHIL
CHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEE
SVTDDDAITVARRLAAEEGVFSGISGGASVATALQIAQQAEPGAVILAMLPDTGERYFST
EECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCC
PLFADINEHSDDAWLASLG
CCEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA