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The map label for this gene is gcvR [H]

Identifier: 182682353

GI number: 182682353

Start: 2041214

End: 2041789

Strand: Direct

Name: gcvR [H]

Synonym: XfasM23_1837

Alternate gene names: 182682353

Gene position: 2041214-2041789 (Clockwise)

Preceding gene: 182682350

Following gene: 182682354

Centisome position: 80.5

GC content: 52.08

Gene sequence:

>576_bases
ATGCCGGACTCCCCTTTGACAGACCCCGCTGCACGGCCCTCGCCGAGCGAAAACTACCTCCTGATCAACGCGTACTCGAT
GCACCCGGAGTCCCCCTTACTCTCCGTGACCCGTCGTATCGCCGATAGCGGCTGCAACCTGATAGAAGCCCGGCTAGCAA
CAGTCGGTCGTGACGTGTCCATAACAACGCTAGCAACCGGATCCTGGGACGCTGTTGCCAAACTTGAAGCGATGCTCTCA
CGACTAGAACGCGAGGAAGGATTGAAACTGATCTGGTACCGTACTGGTGCCAAACAAACTCAGTCCAACCTGCTGCCATA
TATCGTCGAAGTCATTGCCGCCGACAAACAAGGCATTTTGTTTCAGTTGGCCGATTTCTTCGACCGCCAGGGAATTACCA
TAGAAAACCTTCAAAGCACCCGCTATCGGGCAATGCAAACCGGGGCAGAAATGTTCTCGGCACAAATCACTATCGGTATA
CCTGCAAACATGCATATCGCTGCACTACGCGATGATTTTCTAGAGTTCTGTGATCACCTCAATCTTGATGCCATTTTAGA
TCCGATGAAATTCTGA

Upstream 100 bases:

>100_bases
TGGATACAATCCCAAACATGTTACTTGCGGCAAGAAAGCAGGGGCAAGTATGCTGGTCACCGCTCCAAACAGAAAATAGA
GCTCCATTCAGCCTGATGCA

Downstream 100 bases:

>100_bases
ACGCTCAGGTCCCCCTTCCGCATTATCTCCAGACAGCACCTCACCTATGAACATCGGCGACACCCTGAATCATTCGCTTC
TCAACCACCCATTGATGCTA

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MPDSPLTDPAARPSPSENYLLINAYSMHPESPLLSVTRRIADSGCNLIEARLATVGRDVSITTLATGSWDAVAKLEAMLS
RLEREEGLKLIWYRTGAKQTQSNLLPYIVEVIAADKQGILFQLADFFDRQGITIENLQSTRYRAMQTGAEMFSAQITIGI
PANMHIAALRDDFLEFCDHLNLDAILDPMKF

Sequences:

>Translated_191_residues
MPDSPLTDPAARPSPSENYLLINAYSMHPESPLLSVTRRIADSGCNLIEARLATVGRDVSITTLATGSWDAVAKLEAMLS
RLEREEGLKLIWYRTGAKQTQSNLLPYIVEVIAADKQGILFQLADFFDRQGITIENLQSTRYRAMQTGAEMFSAQITIGI
PANMHIAALRDDFLEFCDHLNLDAILDPMKF
>Mature_190_residues
PDSPLTDPAARPSPSENYLLINAYSMHPESPLLSVTRRIADSGCNLIEARLATVGRDVSITTLATGSWDAVAKLEAMLSR
LEREEGLKLIWYRTGAKQTQSNLLPYIVEVIAADKQGILFQLADFFDRQGITIENLQSTRYRAMQTGAEMFSAQITIGIP
ANMHIAALRDDFLEFCDHLNLDAILDPMKF

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=176, Percent_Identity=26.7045454545455, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 21246; Mature: 21114

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSPLTDPAARPSPSENYLLINAYSMHPESPLLSVTRRIADSGCNLIEARLATVGRDVS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCE
ITTLATGSWDAVAKLEAMLSRLEREEGLKLIWYRTGAKQTQSNLLPYIVEVIAADKQGIL
EEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHH
FQLADFFDRQGITIENLQSTRYRAMQTGAEMFSAQITIGIPANMHIAALRDDFLEFCDHL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCC
NLDAILDPMKF
CHHHHCCCCCC
>Mature Secondary Structure 
PDSPLTDPAARPSPSENYLLINAYSMHPESPLLSVTRRIADSGCNLIEARLATVGRDVS
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCE
ITTLATGSWDAVAKLEAMLSRLEREEGLKLIWYRTGAKQTQSNLLPYIVEVIAADKQGIL
EEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHH
FQLADFFDRQGITIENLQSTRYRAMQTGAEMFSAQITIGIPANMHIAALRDDFLEFCDHL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCC
NLDAILDPMKF
CHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]