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The map label for this gene is dapA [H]

Identifier: 182682352

GI number: 182682352

Start: 2040153

End: 2041109

Strand: Reverse

Name: dapA [H]

Synonym: XfasM23_1836

Alternate gene names: 182682352

Gene position: 2041109-2040153 (Counterclockwise)

Preceding gene: 182682356

Following gene: 182682351

Centisome position: 80.5

GC content: 53.71

Gene sequence:

>957_bases
TTGTACTTCAAAGCTGTTGTCCTCATTAATTTTAAGAGTATTACTGTCTTGTCACTTTCCGGGATTATTACTGCGCTGGT
CACTCCGTTTGATCGAGATGGTGCGTTTGACCGTGATGCGTGGATTCGTCTGCTGGATATGCAATTAGCGGGTGGCGTGC
AGGGCGTGGTTATTGCTGGTTCCACCGGCGAAGCAGCGACGTTGACCGATGCTGAGTATGACGAGATGCTGTGCTCGGCT
GTGGTCCGAGTTGGTGGGCGTGTGCCGGTGTTGGCGGGTACTGGTTTGTCTGGGACTGCGAAAACGATTTCTCAAACTAA
ACGCGCGGCCGACAATGGTGCAGGCTATGCTTTGGTGGTGACCCCTCCGTACATACGTCCCAACCAAGGTGGTCTGAAGG
CGCATTATTTGGCTGTGGCTGAGCAGGGGGGATTGCCAGTCGTGCTGTACAATGTGCCTAGCCGCACCGGCTGTGATCTG
TTGCCGGAGACTGTCGCTGATTTGGCGGGGCACCCTAATATTGTCGGCATTAAGGAGGCGTGCGCTAGTCGTGAGCGCGT
CCAGGCGCTGCTTGCTTTGCGTCGTCCAGGCTTTGCTGTATTCAGTGGTGATGACAGCAGTGCTGCGCGTTCGATGTTGG
ACGGTGCCGATGGTTTGGTTTCGGTTGCTTCCAACGTATTGCCGTCCGCTTATCGTCATCTATGTGATCTTGCTCGGGCG
GGTGAGCGTGGTGCTATCGATCTGTGGAATGCGCGTCTGTCTGATTTTCACGCATTTTGTGGTCTCGACTCCAATCCGAT
TCCAATTAAGGCATTGTTACAGCGTATCGGCATTGGTTATGGATTGCGTCTGCCACTGCTACCCTTGTCGGTATGCCATC
ATGACATTGCCGATCACTTGGCTGACCAAGTGGCGGCATTGGAAGCACTTTCTAGCCGTAAAATAGTTACGGCCTGA

Upstream 100 bases:

>100_bases
TCAGGCTGAATGGAGCTCTATTTTCTGTTTGGAGCGGTGACCAGCATACTTGCCCCTGCTTTCTTGCCGCAAGTAACATG
TTTGGGATTGTATCCATGGC

Downstream 100 bases:

>100_bases
CACATCAGGAGATTTTTCGATGCGTTTTTCTGTTACTACTCTTCACGTGTATGCACTCGTGTTATTGGTCGTTGCTGCAT
TGAGTGGTTGTACTTTGTTG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MYFKAVVLINFKSITVLSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEMLCSA
VVRVGGRVPVLAGTGLSGTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDL
LPETVADLAGHPNIVGIKEACASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARA
GERGAIDLWNARLSDFHAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIVTA

Sequences:

>Translated_318_residues
MYFKAVVLINFKSITVLSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEMLCSA
VVRVGGRVPVLAGTGLSGTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDL
LPETVADLAGHPNIVGIKEACASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARA
GERGAIDLWNARLSDFHAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIVTA
>Mature_318_residues
MYFKAVVLINFKSITVLSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEMLCSA
VVRVGGRVPVLAGTGLSGTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDL
LPETVADLAGHPNIVGIKEACASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARA
GERGAIDLWNARLSDFHAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIVTA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=230, Percent_Identity=34.3478260869565, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1788823, Length=274, Percent_Identity=42.3357664233577, Blast_Score=209, Evalue=1e-55,
Organism=Escherichia coli, GI87082415, Length=266, Percent_Identity=32.3308270676692, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786463, Length=228, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789620, Length=228, Percent_Identity=27.1929824561404, Blast_Score=95, Evalue=7e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33395; Mature: 33395

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFKAVVLINFKSITVLSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAG
CCEEEEEEEEECCEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
STGEAATLTDAEYDEMLCSAVVRVGGRVPVLAGTGLSGTAKTISQTKRAADNGAGYALVV
CCCCCEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEE
TPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDLLPETVADLAGHPNIVGIKEA
ECCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEHHHH
CASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARA
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
GERGAIDLWNARLSDFHAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHL
CCCCCEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ADQVAALEALSSRKIVTA
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYFKAVVLINFKSITVLSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAG
CCEEEEEEEEECCEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
STGEAATLTDAEYDEMLCSAVVRVGGRVPVLAGTGLSGTAKTISQTKRAADNGAGYALVV
CCCCCEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEE
TPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDLLPETVADLAGHPNIVGIKEA
ECCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEHHHH
CASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARA
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
GERGAIDLWNARLSDFHAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHL
CCCCCEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ADQVAALEALSSRKIVTA
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]