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The map label for this gene is tmk

Identifier: 182682175

GI number: 182682175

Start: 1833009

End: 1833662

Strand: Reverse

Name: tmk

Synonym: XfasM23_1654

Alternate gene names: 182682175

Gene position: 1833662-1833009 (Counterclockwise)

Preceding gene: 182682176

Following gene: 182682170

Centisome position: 72.31

GC content: 55.81

Gene sequence:

>654_bases
ATGCACGATCAGATCATTCCATGTGGGATGCTCGTCGCCATCGAGGGGATTGATGGTGCCGGAAAGACCACGTTAGCTCG
GAGTTTGGCGCTTAAGTTACGAGGTGTCGGGTTGGAAACGGTGGTCAGTAAGGAGCCGACCAACGGTCCATGGGGCACGC
TGTTGCGGCAGTCTGCTGTGACCGGGCGTTTTTCCCCCGAGGAGGAGGTTGATGTGTTGTTGCGTGATCGTCGCCAGCAT
GTTGAAGATCTTATTGTTCCGATGATCGGCCGTGGTGCGGTGGTGATCTTGGACCGCTATTTCCCGTCGATGGTGGCTTA
TCAGGGCGCTGCCGGGTTACCAGTGGATGCTTTGCTTGAGGCCAATGCGTTTGCTCCACGTCCGGATGTTCTGTTGTTGC
TGGATGTGCCGCCAGTGATTGGTTTGCAGCGTATCTGGGAGCGGGGGAGCACGCCAAATCACTTTGAAACTACGGAAAAT
CTGTCGCGTTGCCGTGACATTTTCCTAGCATTGGAACTGCCATCTAAACGGGTGATTGATGCAACGGCCAATGCTGAAAC
GGTGTTCTCTGCGGCACTGGGCTTGGTGATGGAGGTATTGCGGGTGCGTCTGGGCGCATTAGGTGCGGTGGTGTTGGAGC
GTCTTGCTGGCTAA

Upstream 100 bases:

>100_bases
ATTCCGTGTCTGCTTTAGGTGGGTATGTGTGCGACTCATGGGATGGTTGTTCATGGTAGGAGGCTTATTAGGATGGCCCG
TGGTCGGTTAAAGTAGCCCG

Downstream 100 bases:

>100_bases
GGTGTGTGATGTTGTAGGGGCATCGTTCTAAATAAACAACGTATCAGAGGTAGGTGTGTTGTTGGATGCGCGTGTTGACA
GCTTAGGTCTATCAATGGGT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MHDQIIPCGMLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEEVDVLLRDRRQH
VEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTEN
LSRCRDIFLALELPSKRVIDATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG

Sequences:

>Translated_217_residues
MHDQIIPCGMLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEEVDVLLRDRRQH
VEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTEN
LSRCRDIFLALELPSKRVIDATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG
>Mature_217_residues
MHDQIIPCGMLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEEVDVLLRDRRQH
VEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTEN
LSRCRDIFLALELPSKRVIDATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=195, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_XYLF2 (B2I7G4)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830335.1
- GeneID:   6202015
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1654
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- ProtClustDB:   PRK00698
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23451; Mature: 23451

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDQIIPCGMLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAV
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHH
TGRFSPEEEVDVLLRDRRQHVEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCHHHHHH
ANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTENLSRCRDIFLALELPSKRVID
CCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEE
ATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHDQIIPCGMLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAV
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHH
TGRFSPEEEVDVLLRDRRQHVEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCHHHHHH
ANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTENLSRCRDIFLALELPSKRVID
CCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEE
ATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA