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The map label for this gene is lspA

Identifier: 182682042

GI number: 182682042

Start: 1686997

End: 1687500

Strand: Reverse

Name: lspA

Synonym: XfasM23_1520

Alternate gene names: 182682042

Gene position: 1687500-1686997 (Counterclockwise)

Preceding gene: 182682043

Following gene: 182682041

Centisome position: 66.55

GC content: 57.34

Gene sequence:

>504_bases
ATGACCAGACCCACCCACCCCAACGCCCTGATCTGGTTACTGCTTTCCATTGCCATCATTGCACTGGACCAAGCCACCAA
AGCCTGGGTACTCACCAGCCTCCCCGAATACATCCCCGTCCCCGTCATTCATGGATTCTGGAACTGGTACCGCAGCTACA
ACACCGGCGCCGCCTTTAGCTTCCTCAGCGACGCCGGCGGCTGGCAAATGTGGCTCTTCATTGCATTAGCCCTTGGCATC
AGCGGCCTACTTACCTTCTGGCTCTCCCGTACCCCACGCCGCGAATGGCGCAGCGCATTGCCCTATGCACTGATTATTGG
CGGAGGCATCGGTAACGTCATTGACCGCTTCCTCCATGGCCACGTCGTCGACTTTATCCAATGGTACGTCGGCTCCTACT
ACTGGCCCTCCTTTAACCTTGCAGACTCAGCCATCGTCGCCGGAGCCATCGGTATCGGCCTACTGAGCCTATTTGACAGC
AAACACTCCCCCAAAACCCCATAA

Upstream 100 bases:

>100_bases
AGCAACAGGCCCCTCAGACCGCATCACCACCCACCCGGGTGCCCCTCCCCACACCTTCGCAACACACCACCACACCCCAG
CCCCACAACGACTGACCACC

Downstream 100 bases:

>100_bases
TTTCCGTTCCTACCCCCTTCCTGACATCGCGCCCCACCATCCCATGGAAACCACGCAATGAAAGTTCTGCTCGCTAATCC
GCGCGGCTTCTGTGCAGGCG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MTRPTHPNALIWLLLSIAIIALDQATKAWVLTSLPEYIPVPVIHGFWNWYRSYNTGAAFSFLSDAGGWQMWLFIALALGI
SGLLTFWLSRTPRREWRSALPYALIIGGGIGNVIDRFLHGHVVDFIQWYVGSYYWPSFNLADSAIVAGAIGIGLLSLFDS
KHSPKTP

Sequences:

>Translated_167_residues
MTRPTHPNALIWLLLSIAIIALDQATKAWVLTSLPEYIPVPVIHGFWNWYRSYNTGAAFSFLSDAGGWQMWLFIALALGI
SGLLTFWLSRTPRREWRSALPYALIIGGGIGNVIDRFLHGHVVDFIQWYVGSYYWPSFNLADSAIVAGAIGIGLLSLFDS
KHSPKTP
>Mature_166_residues
TRPTHPNALIWLLLSIAIIALDQATKAWVLTSLPEYIPVPVIHGFWNWYRSYNTGAAFSFLSDAGGWQMWLFIALALGIS
GLLTFWLSRTPRREWRSALPYALIIGGGIGNVIDRFLHGHVVDFIQWYVGSYYWPSFNLADSAIVAGAIGIGLLSLFDSK
HSPKTP

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=165, Percent_Identity=38.7878787878788, Blast_Score=116, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_XYLF2 (B2I6V1)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830202.1
- GeneID:   6202556
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1520
- HOGENOM:   HBG724422
- OMA:   EYYWPAF
- ProtClustDB:   PRK00376
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18649; Mature: 18518

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 115-115 ACT_SITE 142-142

Signals:

None

Transmembrane regions:

HASH(0x157270bc)-; HASH(0x15314cbc)-; HASH(0x15d08e20)-; HASH(0x1498f32c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPTHPNALIWLLLSIAIIALDQATKAWVLTSLPEYIPVPVIHGFWNWYRSYNTGAAFS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHH
FLSDAGGWQMWLFIALALGISGLLTFWLSRTPRREWRSALPYALIIGGGIGNVIDRFLHG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHH
HVVDFIQWYVGSYYWPSFNLADSAIVAGAIGIGLLSLFDSKHSPKTP
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
TRPTHPNALIWLLLSIAIIALDQATKAWVLTSLPEYIPVPVIHGFWNWYRSYNTGAAFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHH
FLSDAGGWQMWLFIALALGISGLLTFWLSRTPRREWRSALPYALIIGGGIGNVIDRFLHG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHH
HVVDFIQWYVGSYYWPSFNLADSAIVAGAIGIGLLSLFDSKHSPKTP
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA