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The map label for this gene is yahK [H]

Identifier: 182682017

GI number: 182682017

Start: 1652855

End: 1653904

Strand: Reverse

Name: yahK [H]

Synonym: XfasM23_1492

Alternate gene names: 182682017

Gene position: 1653904-1652855 (Counterclockwise)

Preceding gene: 182682018

Following gene: 182682016

Centisome position: 65.23

GC content: 52.48

Gene sequence:

>1050_bases
ATGTTTATCAATGCTTACGGTGCACACGCTGGGGATAAACCCTTGGAATCCATGCAGATTGCCCGTCGTGCTCCGGGTGC
GCATGATGTGCAAATTGATATTCATTACTGTGGCGTGTGCCATTCCGATATTCATCAAGTACGGGCTGAATGGGCGGGCA
CGCTTTTTCCGTGTGTACCAGGACATGAAATTGTCGGTCGGGTCTCTGCCATCGGGACGCATGTGCAGGGCTTTAAGGCG
GGAGATCTTGTCGCTGTTGGCTGCATGGTCGATAGCTGCAAGGATTGCCAGGAGTGCGATGCAGGGTTGGAGAATTACTG
CGATGGCATGATTGGTACCTATAACTTCCCGACTCAGGATGCTCCGGGCCATACATTGGGTGGTTATTCTCAGAAGATCG
TTGTGCATGAGCGCTTTGTGTTGCGCATCCGCCACCCTGAGGCACAGCTTGCCGCAGTCGCACCGTTATTGTGTGCCGGG
ATTACGACGTACTCGCCACTGCGCCATTGGAATGCTGGTCCGGGTAAGAAAGTCGGCATTGTCGGCATTGGTGGCTTGGG
TCATATGGGGATTAAGTTGGCTCATGCCATGGGGGCGTATGTCGTTGCGTTCACCACGTCCGAATCTAAGCGACAGGATG
CCAAGGCGCTGGGAGCAGATGAGGTGGTGGTGTCACGTGATGAGGAAAGGATGGCTGCCCATGTAAAGAGTTTCGATTTG
ATTTTGAATACTGTGGCTGCCTCGCATTCTCTTGATCCTTTCCTGACTCTGCTGAAGCGGGATGGCACATTGACCTTGGT
TGGTGCGCCTGTTACGCCGCATCCTTCACCGGAAGTCTTCAATCTGATCTTTAAGCGTCGTTCCATTGCTGGATCGCTGA
TCGGTGGTATTGCAGAAACACAGGAAATGCTGGATTTCTGTGCGGAGCATGGCATTGTTGCGGACATTGAGTTGATCCGT
GCCGACGGTATCAATGAGGCCTACGAACGAATGATGAAAGGCGATGTCAAGTACCGTTTTGTGATTGACAATGCCACTTT
GGCTGCTTGA

Upstream 100 bases:

>100_bases
AGCAACATTGCTTGTAAGTGTGCGGTAAATCAGTATGTGCTTGGCCGCTCTATTACCGCTTTTTTCACTGAAAAATACTT
ATATAAAAGGAGACTTCCTA

Downstream 100 bases:

>100_bases
TGGCACATGCAGAATTTCACATGGCTGATGAAATAGCGGCATTGTGTCTGCCGTTGGATTGAACAACCGCGCTAGGCCTT
GGGTATTACCGCTCATGCAC

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MFINAYGAHAGDKPLESMQIARRAPGAHDVQIDIHYCGVCHSDIHQVRAEWAGTLFPCVPGHEIVGRVSAIGTHVQGFKA
GDLVAVGCMVDSCKDCQECDAGLENYCDGMIGTYNFPTQDAPGHTLGGYSQKIVVHERFVLRIRHPEAQLAAVAPLLCAG
ITTYSPLRHWNAGPGKKVGIVGIGGLGHMGIKLAHAMGAYVVAFTTSESKRQDAKALGADEVVVSRDEERMAAHVKSFDL
ILNTVAASHSLDPFLTLLKRDGTLTLVGAPVTPHPSPEVFNLIFKRRSIAGSLIGGIAETQEMLDFCAEHGIVADIELIR
ADGINEAYERMMKGDVKYRFVIDNATLAA

Sequences:

>Translated_349_residues
MFINAYGAHAGDKPLESMQIARRAPGAHDVQIDIHYCGVCHSDIHQVRAEWAGTLFPCVPGHEIVGRVSAIGTHVQGFKA
GDLVAVGCMVDSCKDCQECDAGLENYCDGMIGTYNFPTQDAPGHTLGGYSQKIVVHERFVLRIRHPEAQLAAVAPLLCAG
ITTYSPLRHWNAGPGKKVGIVGIGGLGHMGIKLAHAMGAYVVAFTTSESKRQDAKALGADEVVVSRDEERMAAHVKSFDL
ILNTVAASHSLDPFLTLLKRDGTLTLVGAPVTPHPSPEVFNLIFKRRSIAGSLIGGIAETQEMLDFCAEHGIVADIELIR
ADGINEAYERMMKGDVKYRFVIDNATLAA
>Mature_349_residues
MFINAYGAHAGDKPLESMQIARRAPGAHDVQIDIHYCGVCHSDIHQVRAEWAGTLFPCVPGHEIVGRVSAIGTHVQGFKA
GDLVAVGCMVDSCKDCQECDAGLENYCDGMIGTYNFPTQDAPGHTLGGYSQKIVVHERFVLRIRHPEAQLAAVAPLLCAG
ITTYSPLRHWNAGPGKKVGIVGIGGLGHMGIKLAHAMGAYVVAFTTSESKRQDAKALGADEVVVSRDEERMAAHVKSFDL
ILNTVAASHSLDPFLTLLKRDGTLTLVGAPVTPHPSPEVFNLIFKRRSIAGSLIGGIAETQEMLDFCAEHGIVADIELIR
ADGINEAYERMMKGDVKYRFVIDNATLAA

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=28.2548476454294, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501929, Length=316, Percent_Identity=28.1645569620253, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI34577061, Length=357, Percent_Identity=27.4509803921569, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71565152, Length=357, Percent_Identity=24.9299719887955, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI71743840, Length=325, Percent_Identity=25.2307692307692, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI262073058, Length=325, Percent_Identity=25.2307692307692, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71565154, Length=237, Percent_Identity=29.957805907173, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=78.6743515850144, Blast_Score=549, Evalue=1e-158,
Organism=Escherichia coli, GI87082401, Length=345, Percent_Identity=35.3623188405797, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=25.8675078864353, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786552, Length=361, Percent_Identity=27.4238227146814, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI226510992, Length=257, Percent_Identity=27.2373540856031, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788407, Length=250, Percent_Identity=27.6, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=337, Percent_Identity=28.7833827893175, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=30.1449275362319, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71988145, Length=355, Percent_Identity=27.0422535211268, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25146526, Length=366, Percent_Identity=27.3224043715847, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=27.1739130434783, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=241, Percent_Identity=30.2904564315353, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=238, Percent_Identity=31.0924369747899, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=272, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=329, Percent_Identity=39.5136778115502, Blast_Score=178, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6319621, Length=342, Percent_Identity=32.1637426900585, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324486, Length=338, Percent_Identity=31.3609467455621, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=31.6568047337278, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319949, Length=331, Percent_Identity=36.5558912386707, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=29.8780487804878, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=29.2349726775956, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=311, Percent_Identity=25.4019292604502, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=24.0997229916898, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 37495; Mature: 37495

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFINAYGAHAGDKPLESMQIARRAPGAHDVQIDIHYCGVCHSDIHQVRAEWAGTLFPCVP
CEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCC
GHEIVGRVSAIGTHVQGFKAGDLVAVGCMVDSCKDCQECDAGLENYCDGMIGTYNFPTQD
CHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHCCHHHHHCCHHHHHCCCCCCCCCCCCC
APGHTLGGYSQKIVVHERFVLRIRHPEAQLAAVAPLLCAGITTYSPLRHWNAGPGKKVGI
CCCCCCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCEEEE
VGIGGLGHMGIKLAHAMGAYVVAFTTSESKRQDAKALGADEVVVSRDEERMAAHVKSFDL
EEECCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
ILNTVAASHSLDPFLTLLKRDGTLTLVGAPVTPHPSPEVFNLIFKRRSIAGSLIGGIAET
HHHHHHHHCCCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QEMLDFCAEHGIVADIELIRADGINEAYERMMKGDVKYRFVIDNATLAA
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCEECC
>Mature Secondary Structure
MFINAYGAHAGDKPLESMQIARRAPGAHDVQIDIHYCGVCHSDIHQVRAEWAGTLFPCVP
CEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCC
GHEIVGRVSAIGTHVQGFKAGDLVAVGCMVDSCKDCQECDAGLENYCDGMIGTYNFPTQD
CHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHCCHHHHHCCHHHHHCCCCCCCCCCCCC
APGHTLGGYSQKIVVHERFVLRIRHPEAQLAAVAPLLCAGITTYSPLRHWNAGPGKKVGI
CCCCCCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCEEEE
VGIGGLGHMGIKLAHAMGAYVVAFTTSESKRQDAKALGADEVVVSRDEERMAAHVKSFDL
EEECCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
ILNTVAASHSLDPFLTLLKRDGTLTLVGAPVTPHPSPEVFNLIFKRRSIAGSLIGGIAET
HHHHHHHHCCCCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QEMLDFCAEHGIVADIELIRADGINEAYERMMKGDVKYRFVIDNATLAA
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]