Click here to switch to the map view.

The map label for this gene is folC [H]

Identifier: 182681451

GI number: 182681451

Start: 1071304

End: 1072602

Strand: Reverse

Name: folC [H]

Synonym: XfasM23_0902

Alternate gene names: 182681451

Gene position: 1072602-1071304 (Counterclockwise)

Preceding gene: 182681453

Following gene: 182681450

Centisome position: 42.3

GC content: 51.89

Gene sequence:

>1299_bases
ATGACTGCACAAAAAACTCTTTCCGAATGGCTTGCATATATCCAACAACAACACCCGCAGTCAATCTCTATGGGCTTGGA
GCGCGTGAGCGCTGTGGCCAAGTCAATGGGGTTGGTCCATCCGGCGCGGCACTGCATTGTAGTCGGAGGGACTAATGGCA
AAGGGTCGACAGTAGCGTTCATTGAGGCGATAGCGCGCGCGGCAGGTTGGAAAGTCGGCACCTACACCTCACCCCACCTA
CTGCGGTACAACGAGCGAGTACGCATTGATGGCAGAGAGGTTGATGATGCACTCCTGGTCGAAGCTTTCTCCAGGGTTGA
AGTAGCACGCAAACAAACTGAACTGACTTTTTTTGAGTTTGGCACTTTGGCTGCTTTCTGGTTATTTTCGCGCGCCGTGC
TTGATTTGGCGATACTGGAAGTGGGACTAGGTGGGCGCCTGGATGCAGTCAATTTAGTCGATGCCGACGTGGCTGTAATT
ACCACTGTGGACATCGACCATACCGAATGGCTAGGTAGCGATCGCGAGGCCATCGGTAAAGAAAAAGCTGGCATTATTCG
AAGTTGGAAGCCAGTGGTGCTGGGTGAGCTTGACCCGCCATCAAGCGTTCTGCGCCATGCCTACTTACTTGGTGCCAATG
CGATCCGCGCTGGTAGCGATTTTTTCTACGAAAAAATCAATGAAAAGCACTGGCGCTGGTGGGATGTTTCACTATGCATG
GAGTTACCCTTGCCTGCACTCAGTGCACCAATACAGCTAGCCAATGCAGCCTCTGCAATTGCTGCGTTGCGTGCGCTGCC
ACGAACTCTACCATTTGAAGCTTGGAGCGACGGTATAGCAAAAGCAACGATTGCTGGACGGTTACAAGCATTCCAGATAG
GAGCTATTCAAGTCTTGCTTGATGTCGGTCACAACCCGCAAGCTGCACAGGTACTCGCTTCTGCGCTGCGTACTCAACCG
ATACAAGGTAACGTTACCCATGCAGTCTATGCTGCGCTGGTCGATAAGGATGTGCTAGGAGTCGCTACTGCTCTGGCTGA
GATAGTGACACATTGGCACTTGGCTGGGCTGGATTGCTTACGTGGGCAATCGGCTGAATGTTTGGCTGGACGACTTGCAG
AAATATCAGTGGTACCTTCCAGCCTTTCCGGAAGCGTTACCGAAGCATTACAGCAAACGTTACAAACTGCGGCTCCAGGT
GACCGGGTACTTGTATTCGGCTCGTTCCATACCGTAGCTGAGGCTTTGCTACTGCTTGGTTCATTTGACAAGAGTGAAGC
ATTGCCAGTAGACGTATAA

Upstream 100 bases:

>100_bases
AAAGGGGCCAAAAAATAATTTCCATTAAAGAATTCTACCTTTTTACTAAAAGGTATATAACAATCAGCTGCGTTTGTCTT
ACCTATGGCTGTTAGTCACC

Downstream 100 bases:

>100_bases
TCTATAACGCTTTAATTTTAGTGTGGTGCTTTCCAACAGTGGACATTGCTTTGAAACAGCGACTGATCGGTGCCGTCATT
CTAGTGGCGCTCGCCGTAAT

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTAQKTLSEWLAYIQQQHPQSISMGLERVSAVAKSMGLVHPARHCIVVGGTNGKGSTVAFIEAIARAAGWKVGTYTSPHL
LRYNERVRIDGREVDDALLVEAFSRVEVARKQTELTFFEFGTLAAFWLFSRAVLDLAILEVGLGGRLDAVNLVDADVAVI
TTVDIDHTEWLGSDREAIGKEKAGIIRSWKPVVLGELDPPSSVLRHAYLLGANAIRAGSDFFYEKINEKHWRWWDVSLCM
ELPLPALSAPIQLANAASAIAALRALPRTLPFEAWSDGIAKATIAGRLQAFQIGAIQVLLDVGHNPQAAQVLASALRTQP
IQGNVTHAVYAALVDKDVLGVATALAEIVTHWHLAGLDCLRGQSAECLAGRLAEISVVPSSLSGSVTEALQQTLQTAAPG
DRVLVFGSFHTVAEALLLLGSFDKSEALPVDV

Sequences:

>Translated_432_residues
MTAQKTLSEWLAYIQQQHPQSISMGLERVSAVAKSMGLVHPARHCIVVGGTNGKGSTVAFIEAIARAAGWKVGTYTSPHL
LRYNERVRIDGREVDDALLVEAFSRVEVARKQTELTFFEFGTLAAFWLFSRAVLDLAILEVGLGGRLDAVNLVDADVAVI
TTVDIDHTEWLGSDREAIGKEKAGIIRSWKPVVLGELDPPSSVLRHAYLLGANAIRAGSDFFYEKINEKHWRWWDVSLCM
ELPLPALSAPIQLANAASAIAALRALPRTLPFEAWSDGIAKATIAGRLQAFQIGAIQVLLDVGHNPQAAQVLASALRTQP
IQGNVTHAVYAALVDKDVLGVATALAEIVTHWHLAGLDCLRGQSAECLAGRLAEISVVPSSLSGSVTEALQQTLQTAAPG
DRVLVFGSFHTVAEALLLLGSFDKSEALPVDV
>Mature_431_residues
TAQKTLSEWLAYIQQQHPQSISMGLERVSAVAKSMGLVHPARHCIVVGGTNGKGSTVAFIEAIARAAGWKVGTYTSPHLL
RYNERVRIDGREVDDALLVEAFSRVEVARKQTELTFFEFGTLAAFWLFSRAVLDLAILEVGLGGRLDAVNLVDADVAVIT
TVDIDHTEWLGSDREAIGKEKAGIIRSWKPVVLGELDPPSSVLRHAYLLGANAIRAGSDFFYEKINEKHWRWWDVSLCME
LPLPALSAPIQLANAASAIAALRALPRTLPFEAWSDGIAKATIAGRLQAFQIGAIQVLLDVGHNPQAAQVLASALRTQPI
QGNVTHAVYAALVDKDVLGVATALAEIVTHWHLAGLDCLRGQSAECLAGRLAEISVVPSSLSGSVTEALQQTLQTAAPGD
RVLVFGSFHTVAEALLLLGSFDKSEALPVDV

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=169, Percent_Identity=37.8698224852071, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI66932984, Length=169, Percent_Identity=37.8698224852071, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1788654, Length=415, Percent_Identity=45.0602409638554, Blast_Score=311, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17553148, Length=188, Percent_Identity=35.6382978723404, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71984923, Length=188, Percent_Identity=35.6382978723404, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17553150, Length=188, Percent_Identity=35.6382978723404, Blast_Score=114, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323760, Length=319, Percent_Identity=26.6457680250784, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324815, Length=175, Percent_Identity=32, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24641571, Length=285, Percent_Identity=29.1228070175439, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24581568, Length=145, Percent_Identity=37.2413793103448, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 46440; Mature: 46309

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQKTLSEWLAYIQQQHPQSISMGLERVSAVAKSMGLVHPARHCIVVGGTNGKGSTVAF
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHH
IEAIARAAGWKVGTYTSPHLLRYNERVRIDGREVDDALLVEAFSRVEVARKQTELTFFEF
HHHHHHHHCCCCCCCCCCHHEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GTLAAFWLFSRAVLDLAILEVGLGGRLDAVNLVDADVAVITTVDIDHTEWLGSDREAIGK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEEECCCHHHCCCCHHHHCC
EKAGIIRSWKPVVLGELDPPSSVLRHAYLLGANAIRAGSDFFYEKINEKHWRWWDVSLCM
HHHCHHCCCCCEEEECCCCHHHHHHHHHHHCCCHHHCCHHHHHHHHCCCCCEEEEHHHHH
ELPLPALSAPIQLANAASAIAALRALPRTLPFEAWSDGIAKATIAGRLQAFQIGAIQVLL
HCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHEEHHHHHEEE
DVGHNPQAAQVLASALRTQPIQGNVTHAVYAALVDKDVLGVATALAEIVTHWHLAGLDCL
ECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
RGQSAECLAGRLAEISVVPSSLSGSVTEALQQTLQTAAPGDRVLVFGSFHTVAEALLLLG
CCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHC
SFDKSEALPVDV
CCCCCCCCCCCC
>Mature Secondary Structure 
TAQKTLSEWLAYIQQQHPQSISMGLERVSAVAKSMGLVHPARHCIVVGGTNGKGSTVAF
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHH
IEAIARAAGWKVGTYTSPHLLRYNERVRIDGREVDDALLVEAFSRVEVARKQTELTFFEF
HHHHHHHHCCCCCCCCCCHHEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GTLAAFWLFSRAVLDLAILEVGLGGRLDAVNLVDADVAVITTVDIDHTEWLGSDREAIGK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEEECCCHHHCCCCHHHHCC
EKAGIIRSWKPVVLGELDPPSSVLRHAYLLGANAIRAGSDFFYEKINEKHWRWWDVSLCM
HHHCHHCCCCCEEEECCCCHHHHHHHHHHHCCCHHHCCHHHHHHHHCCCCCEEEEHHHHH
ELPLPALSAPIQLANAASAIAALRALPRTLPFEAWSDGIAKATIAGRLQAFQIGAIQVLL
HCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHEEHHHHHEEE
DVGHNPQAAQVLASALRTQPIQGNVTHAVYAALVDKDVLGVATALAEIVTHWHLAGLDCL
ECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
RGQSAECLAGRLAEISVVPSSLSGSVTEALQQTLQTAAPGDRVLVFGSFHTVAEALLLLG
CCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHC
SFDKSEALPVDV
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]