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The map label for this gene is lpxD [H]

Identifier: 182681235

GI number: 182681235

Start: 802606

End: 803490

Strand: Direct

Name: lpxD [H]

Synonym: XfasM23_0680

Alternate gene names: 182681235

Gene position: 802606-803490 (Clockwise)

Preceding gene: 182681233

Following gene: 182681236

Centisome position: 31.65

GC content: 47.12

Gene sequence:

>885_bases
ATGAATGACACCTTTGACTACATATTTGGCTATGCGCTAAGCACCGCCCTTGCGCGGTATTGGGTTAACCCAGACGGAAG
CCAAGGCGGCATTGTTTCTATTGATGCCAAGATAGATGCTTCCGTCATGATCGGCAAAGACGCCGTGGTATTTCCTGATG
CAAACATTGCTGAAAGAGCTTGTATCGCGGAAAAAGTCTGCATCGGCAATGCGGTACGCATTGGTAAGCATGCGATGATT
GATCATGGTGCCAGCATCGGTGACAGGTCGAACATCGGTGAAAGATCTAGGATTTATCAAGATTCCTTCATCGGCGAAAA
TGCTGTCATTGCCGCAAGAGCTTGTATCGGTGAAAAAGTCTACATTGGAAATTTTGTAAGCCTTGCTAAGGATTCCATCA
TTGATGATGGTGTCAACATCGGTGAAAGGTCGAGCATTGGTGAAAGAACTAGGATTCGCCAAGGGTCGTTCATTCGTAAA
GGTTGCGTCATCCGCCAACGTTCTGTGATTGCCAAACGTGCCTATATTGATGAAGGAGTCTATATCGGTAACGTGGTACG
CATTGGTGAAGAATCAATGATCCATCGTAGAAGCCGTATCGGATCTGGTGCGCGTATTGGTGGATCAGTATGCATTGGTG
TTTACTGTCGCATTGATGGTTCAGTACGCATTGGTCAGCACGCTGATATTGGCGAATGGGTCAACATTGATGGGCATGCC
CGCATCGGCAATTTTGCCCGCATTGGTGAGTGGTCAAGAATTGGTGGGCGCGCCAACATTGCAGCTCACGTCGTCCTAGA
AAAACAATCCATCATTCATAGTGAAACTTGCATCCAGGATGCTTCAAAAACTAGCGTTGATATGCCCAAGGATGCAGGGA
TATGA

Upstream 100 bases:

>100_bases
ATGAGGGATGGCCCGCCGTGAATCAAAACGAGAAATTCAAGGAAAAGAGGATAAGCATGCGCGAACCATGTGTCCCTACA
TCACAAGGAGAAATGATGTC

Downstream 100 bases:

>100_bases
AATGCATGTGGAAGACCGTTTTTTATCCCTGGATAGCTATGTAGCGCCCAAGTGCGTGAGACGTGAGATGGCTATGAGCG
AAACAGAATTTCTGACCGCT

Product: UDP-3-O-(3-hydroxymyristoyl)-like protein

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNDTFDYIFGYALSTALARYWVNPDGSQGGIVSIDAKIDASVMIGKDAVVFPDANIAERACIAEKVCIGNAVRIGKHAMI
DHGASIGDRSNIGERSRIYQDSFIGENAVIAARACIGEKVYIGNFVSLAKDSIIDDGVNIGERSSIGERTRIRQGSFIRK
GCVIRQRSVIAKRAYIDEGVYIGNVVRIGEESMIHRRSRIGSGARIGGSVCIGVYCRIDGSVRIGQHADIGEWVNIDGHA
RIGNFARIGEWSRIGGRANIAAHVVLEKQSIIHSETCIQDASKTSVDMPKDAGI

Sequences:

>Translated_294_residues
MNDTFDYIFGYALSTALARYWVNPDGSQGGIVSIDAKIDASVMIGKDAVVFPDANIAERACIAEKVCIGNAVRIGKHAMI
DHGASIGDRSNIGERSRIYQDSFIGENAVIAARACIGEKVYIGNFVSLAKDSIIDDGVNIGERSSIGERTRIRQGSFIRK
GCVIRQRSVIAKRAYIDEGVYIGNVVRIGEESMIHRRSRIGSGARIGGSVCIGVYCRIDGSVRIGQHADIGEWVNIDGHA
RIGNFARIGEWSRIGGRANIAAHVVLEKQSIIHSETCIQDASKTSVDMPKDAGI
>Mature_294_residues
MNDTFDYIFGYALSTALARYWVNPDGSQGGIVSIDAKIDASVMIGKDAVVFPDANIAERACIAEKVCIGNAVRIGKHAMI
DHGASIGDRSNIGERSRIYQDSFIGENAVIAARACIGEKVYIGNFVSLAKDSIIDDGVNIGERSSIGERTRIRQGSFIRK
GCVIRQRSVIAKRAYIDEGVYIGNVVRIGEESMIHRRSRIGSGARIGGSVCIGVYCRIDGSVRIGQHADIGEWVNIDGHA
RIGNFARIGEWSRIGGRANIAAHVVLEKQSIIHSETCIQDASKTSVDMPKDAGI

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 31754; Mature: 31754

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTFDYIFGYALSTALARYWVNPDGSQGGIVSIDAKIDASVMIGKDAVVFPDANIAERA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCCEEEECCCCHHHHH
CIAEKVCIGNAVRIGKHAMIDHGASIGDRSNIGERSRIYQDSFIGENAVIAARACIGEKV
HHHHHHHCCCHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEHHHCCCEE
YIGNFVSLAKDSIIDDGVNIGERSSIGERTRIRQGSFIRKGCVIRQRSVIAKRAYIDEGV
EECHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCE
YIGNVVRIGEESMIHRRSRIGSGARIGGSVCIGVYCRIDGSVRIGQHADIGEWVNIDGHA
EEEEEEEECHHHHHHHHHHCCCCCEECCEEEEEEEEEECCCEEECCCCCCCCEEECCCCC
RIGNFARIGEWSRIGGRANIAAHVVLEKQSIIHSETCIQDASKTSVDMPKDAGI
CCCCHHHCCCHHHCCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNDTFDYIFGYALSTALARYWVNPDGSQGGIVSIDAKIDASVMIGKDAVVFPDANIAERA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCCEEEECCCCHHHHH
CIAEKVCIGNAVRIGKHAMIDHGASIGDRSNIGERSRIYQDSFIGENAVIAARACIGEKV
HHHHHHHCCCHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEHHHCCCEE
YIGNFVSLAKDSIIDDGVNIGERSSIGERTRIRQGSFIRKGCVIRQRSVIAKRAYIDEGV
EECHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCE
YIGNVVRIGEESMIHRRSRIGSGARIGGSVCIGVYCRIDGSVRIGQHADIGEWVNIDGHA
EEEEEEEECHHHHHHHHHHCCCCCEECCEEEEEEEEEECCCEEECCCCCCCCEEECCCCC
RIGNFARIGEWSRIGGRANIAAHVVLEKQSIIHSETCIQDASKTSVDMPKDAGI
CCCCHHHCCCHHHCCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA