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The map label for this gene is rfbD [H]

Identifier: 182680769

GI number: 182680769

Start: 267846

End: 268754

Strand: Direct

Name: rfbD [H]

Synonym: XfasM23_0198

Alternate gene names: 182680769

Gene position: 267846-268754 (Clockwise)

Preceding gene: 182680768

Following gene: 182680772

Centisome position: 10.56

GC content: 59.74

Gene sequence:

>909_bases
GTGACGGTGTTGGTCTTTGGGGCGGGTGGTCAGATTGGTCAGGAGTTGCTGCGGTCACTGAGTGGTCGTGTGGTGTGTGC
CGTCACGCGCAGTGGACGGTTGCCGAATGGGGTGGGGTGTGTGCAGGCGGATTTTGGTCAGCCCGAGACGCTGCGCGCAT
TGCTTGACGCGCAGCGGCCAGTGCAGGTGGTGAATGCGGCTGCTTATACGGCGGTTGACCGTGCGGAATCTGAGCCTGAT
GTGGTGTTCCGTATCAATGCCCAGGCACCAGGTGTGATCGCGCATTGGTGTGCGGAGCATGGGGTGCCGCTGGTGCATTA
TTCCACTGACTATGTGTTTGATGGGCAGGGTACGTCTCCGTACGGTGTGGATGATCCTGTCGCGCCGTTGAATATTTATG
GTGCGAGTAAGCTGGCTGGGGAGTGTGCGGTCCGGGCGGCGGGCGGGTGTTCTCTGATTTTGCGTACGTCCTGGGTTTAT
GCGGCGCATGGCCACAATTTTTTACGCACTATGCTGCGTTTGGGTGCGACATCCGAGTGTTTGCGGGTGGTGGCGGATCA
GATCGGCACGCCGACTGCGGCGGGGTTGATTGCGGATGTTACTGCGCAGTTGTTGGTGGAGCAGGTGCAAAGTCGGCATG
CGGGTATTTGGCATCTGACGGCGGCCGGTCAAACGAGTTGGCATGGTTTTGCTGAGGAGATTTTCGTGCAGGCGCAGGCA
TGCGGTTTGATGATGCGGGTCCCGCAGGTACAGGCCATTGGGAGTGTTGTGTATCCGACTGCGGCGCGGCGTCCGGGGTA
TTCGTGTCTGGATACGACGGCGTTGGTGGAGGCGTTTGGGATCGTGTTACCAGATTGGCGTCAGGGCGTGCGCGGTGTGT
TGGACGAGATCGTCAAGAGGTCGCGTTAA

Upstream 100 bases:

>100_bases
GTGTGGATTGGCCGATTGCTGCGCCGCTGCTCTCGGCTAAGGATCAGAAAGCGCCGTTTATGGAGGAAGTCCCTATTGAT
CGTTTGCCGATATACGTGCC

Downstream 100 bases:

>100_bases
AGGTGAAGTGGGATGATGTTTGCTGAGACTCGGGGGCGAGGGTGTGTCTTGGTGTGCTTGGCTATGTCAGTACGGTGTTG
GGTCGCTGTGCATCACCGCA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTVLVFGAGGQIGQELLRSLSGRVVCAVTRSGRLPNGVGCVQADFGQPETLRALLDAQRPVQVVNAAAYTAVDRAESEPD
VVFRINAQAPGVIAHWCAEHGVPLVHYSTDYVFDGQGTSPYGVDDPVAPLNIYGASKLAGECAVRAAGGCSLILRTSWVY
AAHGHNFLRTMLRLGATSECLRVVADQIGTPTAAGLIADVTAQLLVEQVQSRHAGIWHLTAAGQTSWHGFAEEIFVQAQA
CGLMMRVPQVQAIGSVVYPTAARRPGYSCLDTTALVEAFGIVLPDWRQGVRGVLDEIVKRSR

Sequences:

>Translated_302_residues
MTVLVFGAGGQIGQELLRSLSGRVVCAVTRSGRLPNGVGCVQADFGQPETLRALLDAQRPVQVVNAAAYTAVDRAESEPD
VVFRINAQAPGVIAHWCAEHGVPLVHYSTDYVFDGQGTSPYGVDDPVAPLNIYGASKLAGECAVRAAGGCSLILRTSWVY
AAHGHNFLRTMLRLGATSECLRVVADQIGTPTAAGLIADVTAQLLVEQVQSRHAGIWHLTAAGQTSWHGFAEEIFVQAQA
CGLMMRVPQVQAIGSVVYPTAARRPGYSCLDTTALVEAFGIVLPDWRQGVRGVLDEIVKRSR
>Mature_301_residues
TVLVFGAGGQIGQELLRSLSGRVVCAVTRSGRLPNGVGCVQADFGQPETLRALLDAQRPVQVVNAAAYTAVDRAESEPDV
VFRINAQAPGVIAHWCAEHGVPLVHYSTDYVFDGQGTSPYGVDDPVAPLNIYGASKLAGECAVRAAGGCSLILRTSWVYA
AHGHNFLRTMLRLGATSECLRVVADQIGTPTAAGLIADVTAQLLVEQVQSRHAGIWHLTAAGQTSWHGFAEEIFVQAQAC
GLMMRVPQVQAIGSVVYPTAARRPGYSCLDTTALVEAFGIVLPDWRQGVRGVLDEIVKRSR

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=162, Percent_Identity=31.4814814814815, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI33519455, Length=162, Percent_Identity=31.4814814814815, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788352, Length=300, Percent_Identity=43.3333333333333, Blast_Score=238, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32132; Mature: 32001

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLVFGAGGQIGQELLRSLSGRVVCAVTRSGRLPNGVGCVQADFGQPETLRALLDAQRP
CEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHCCCC
VQVVNAAAYTAVDRAESEPDVVFRINAQAPGVIAHWCAEHGVPLVHYSTDYVFDGQGTSP
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCEEECCCCCCC
YGVDDPVAPLNIYGASKLAGECAVRAAGGCSLILRTSWVYAAHGHNFLRTMLRLGATSEC
CCCCCCCCCEEECCCHHHHHHHHEEECCCCEEEEEEEEEEEECCHHHHHHHHHCCCCHHH
LRVVADQIGTPTAAGLIADVTAQLLVEQVQSRHAGIWHLTAAGQTSWHGFAEEIFVQAQA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
CGLMMRVPQVQAIGSVVYPTAARRPGYSCLDTTALVEAFGIVLPDWRQGVRGVLDEIVKR
HHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SR
CC
>Mature Secondary Structure 
TVLVFGAGGQIGQELLRSLSGRVVCAVTRSGRLPNGVGCVQADFGQPETLRALLDAQRP
EEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHCCCC
VQVVNAAAYTAVDRAESEPDVVFRINAQAPGVIAHWCAEHGVPLVHYSTDYVFDGQGTSP
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCEEECCCCCCC
YGVDDPVAPLNIYGASKLAGECAVRAAGGCSLILRTSWVYAAHGHNFLRTMLRLGATSEC
CCCCCCCCCEEECCCHHHHHHHHEEECCCCEEEEEEEEEEEECCHHHHHHHHHCCCCHHH
LRVVADQIGTPTAAGLIADVTAQLLVEQVQSRHAGIWHLTAAGQTSWHGFAEEIFVQAQA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
CGLMMRVPQVQAIGSVVYPTAARRPGYSCLDTTALVEAFGIVLPDWRQGVRGVLDEIVKR
HHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]