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The map label for this gene is hemF [H]

Identifier: 182680587

GI number: 182680587

Start: 16837

End: 17832

Strand: Direct

Name: hemF [H]

Synonym: XfasM23_0015

Alternate gene names: 182680587

Gene position: 16837-17832 (Clockwise)

Preceding gene: 182680586

Following gene: 182680588

Centisome position: 0.66

GC content: 53.21

Gene sequence:

>996_bases
ATGACCCTCCAAACTTCGGTACATCCGCTGTGTTGTGTGTCTGGTGCGACCTTTTCTTTTCTTTCACTTCAGATTGCTAT
GAGCCATTTCGACCGCGTCCGCGATTACCTGACTGCCCTACAAGATCGTATTTGCAATGTGGTCGAGACCATCGATGGTC
AATCGCATTTTCACCAAGACCACTGGCAGCGTACGGAAGGGGGGGGGGGACGTACCCGTCTCTTGCGTGATGGTGCCGTC
TTTGAACAGGCAGCTATTGGCTTCTCCGATGTCTGCGGTACACATTTACCACCATCGGCCAGCGTGCGCCGTCCTGAACT
GGCTGGTGCCAATTGGCGTGCCTGTGGCGTGTCACTGGTATTCCATCCCAAAAATCCTTTCGTCCCTACCACGCATCTCA
ATGTGCGCTATTTTCGTGCTGAGCGTGAGGGCAAACAAGTTGCTGCTTGGTTTGGCGGTGGTTTTGACCTCACCCCGTTT
TATCCCTTTGATGAAGATGTCGTGCACTGGCACACAGTTGCTCGTGACCTATGCGCCCCATTTGGCGACGAACGTTATGC
AGCGCATAAACGGTGGTGTGACGAATACTTTGTACTGCGTCACCGGAATGAAACACGCGGTGTTGGCGGCTTATTCTTTG
ATGACCTTGATAAGGATTTTGAGCGCGACTTTGATTACCAGCGTGCGGTGGGAGATGGCTTCCTCGACGCTTATTTCCCG
ATTGTGACGCGTCGTCATGACACGCCCTACGGTGATCGTGAGCGTGCGTTTCAGCTGTATCGACGTGGTCGCTACGTAGA
GTTCAATTTGTTATTTGATCGCGGCACATTATTCGGCTTGCAGAGTGGCGGGCGTGCTGAAAGCATTTTGATCAGTCTGC
CGCCGTTGGTGCGCTGGGAATATGGTTACCACCCTTTACCAGGCAGTGCCGAGGCGCGTTTGGCTGACTATCTATTGCCG
CGTGACTGGCTGGAGGAAAGTCGCATTTGCGAATGA

Upstream 100 bases:

>100_bases
CTGTTCACTAAAACAGCGCCGCCGCTGTACTGCGATGTCATCCATGTGTAGCGATATTGATCGCTTGCAGCATGGGCGAA
ATGACGGGTGTGACCGCATA

Downstream 100 bases:

>100_bases
TGTCTGGACTCTGTCCAGTCCGCTGAGAATGATCGTGATCCTAGCGTCCTCCTCTGCTGATACAGCATCGTGACTAGCCT
CATCATCCATTGCCTAGCTA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTLQTSVHPLCCVSGATFSFLSLQIAMSHFDRVRDYLTALQDRICNVVETIDGQSHFHQDHWQRTEGGGGRTRLLRDGAV
FEQAAIGFSDVCGTHLPPSASVRRPELAGANWRACGVSLVFHPKNPFVPTTHLNVRYFRAEREGKQVAAWFGGGFDLTPF
YPFDEDVVHWHTVARDLCAPFGDERYAAHKRWCDEYFVLRHRNETRGVGGLFFDDLDKDFERDFDYQRAVGDGFLDAYFP
IVTRRHDTPYGDRERAFQLYRRGRYVEFNLLFDRGTLFGLQSGGRAESILISLPPLVRWEYGYHPLPGSAEARLADYLLP
RDWLEESRICE

Sequences:

>Translated_331_residues
MTLQTSVHPLCCVSGATFSFLSLQIAMSHFDRVRDYLTALQDRICNVVETIDGQSHFHQDHWQRTEGGGGRTRLLRDGAV
FEQAAIGFSDVCGTHLPPSASVRRPELAGANWRACGVSLVFHPKNPFVPTTHLNVRYFRAEREGKQVAAWFGGGFDLTPF
YPFDEDVVHWHTVARDLCAPFGDERYAAHKRWCDEYFVLRHRNETRGVGGLFFDDLDKDFERDFDYQRAVGDGFLDAYFP
IVTRRHDTPYGDRERAFQLYRRGRYVEFNLLFDRGTLFGLQSGGRAESILISLPPLVRWEYGYHPLPGSAEARLADYLLP
RDWLEESRICE
>Mature_330_residues
TLQTSVHPLCCVSGATFSFLSLQIAMSHFDRVRDYLTALQDRICNVVETIDGQSHFHQDHWQRTEGGGGRTRLLRDGAVF
EQAAIGFSDVCGTHLPPSASVRRPELAGANWRACGVSLVFHPKNPFVPTTHLNVRYFRAEREGKQVAAWFGGGFDLTPFY
PFDEDVVHWHTVARDLCAPFGDERYAAHKRWCDEYFVLRHRNETRGVGGLFFDDLDKDFERDFDYQRAVGDGFLDAYFPI
VTRRHDTPYGDRERAFQLYRRGRYVEFNLLFDRGTLFGLQSGGRAESILISLPPLVRWEYGYHPLPGSAEARLADYLLPR
DWLEESRICE

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=294, Percent_Identity=43.1972789115646, Blast_Score=240, Evalue=1e-63,
Organism=Escherichia coli, GI1788777, Length=294, Percent_Identity=61.5646258503401, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320249, Length=318, Percent_Identity=42.4528301886792, Blast_Score=239, Evalue=3e-64,
Organism=Drosophila melanogaster, GI17864388, Length=306, Percent_Identity=43.7908496732026, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 38022; Mature: 37891

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQTSVHPLCCVSGATFSFLSLQIAMSHFDRVRDYLTALQDRICNVVETIDGQSHFHQD
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
HWQRTEGGGGRTRLLRDGAVFEQAAIGFSDVCGTHLPPSASVRRPELAGANWRACGVSLV
HHHHCCCCCCCEEEEECCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
FHPKNPFVPTTHLNVRYFRAEREGKQVAAWFGGGFDLTPFYPFDEDVVHWHTVARDLCAP
ECCCCCCCCCEECEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
FGDERYAAHKRWCDEYFVLRHRNETRGVGGLFFDDLDKDFERDFDYQRAVGDGFLDAYFP
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHH
IVTRRHDTPYGDRERAFQLYRRGRYVEFNLLFDRGTLFGLQSGGRAESILISLPPLVRWE
HHCCCCCCCCCCHHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCEEEC
YGYHPLPGSAEARLADYLLPRDWLEESRICE
CCCCCCCCCCHHHHHHHHCCHHHHHHHCCCC
>Mature Secondary Structure 
TLQTSVHPLCCVSGATFSFLSLQIAMSHFDRVRDYLTALQDRICNVVETIDGQSHFHQD
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
HWQRTEGGGGRTRLLRDGAVFEQAAIGFSDVCGTHLPPSASVRRPELAGANWRACGVSLV
HHHHCCCCCCCEEEEECCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
FHPKNPFVPTTHLNVRYFRAEREGKQVAAWFGGGFDLTPFYPFDEDVVHWHTVARDLCAP
ECCCCCCCCCEECEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
FGDERYAAHKRWCDEYFVLRHRNETRGVGGLFFDDLDKDFERDFDYQRAVGDGFLDAYFP
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHH
IVTRRHDTPYGDRERAFQLYRRGRYVEFNLLFDRGTLFGLQSGGRAESILISLPPLVRWE
HHCCCCCCCCCCHHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCEEEC
YGYHPLPGSAEARLADYLLPRDWLEESRICE
CCCCCCCCCCHHHHHHHHCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]