Click here to switch to the map view.

The map label for this gene is tyrS

Identifier: 170756799

GI number: 170756799

Start: 3602378

End: 3603601

Strand: Reverse

Name: tyrS

Synonym: CLD_1198

Alternate gene names: 170756799

Gene position: 3603601-3602378 (Counterclockwise)

Preceding gene: 170755593

Following gene: 170756279

Centisome position: 91.04

GC content: 30.64

Gene sequence:

>1224_bases
TTGAGTAATGTATATGACATATTAAAAGAACGTGGTTATATAAAACAATTAACACATGAAGAAGAAATAAGAGAACTTTT
AGGTAAAGAAAAAATTTCTTTTTATATAGGTTTTGATCCTACAGCAGATAGCTTACATGTAGGTCACTTCCTTCAAATGA
TGGTTATGGCTCATATGCAAAAGGCTGGACATAGACCTATAGCATTAGTAGGTGGAGGAACAGGAATGATAGGGGATCCT
ACTGGTAAAACAGATATGAGAAAGATGATGACAAAAGAGCAAATAGAGCATAACTGTAACTGTTTTAAAAAGCAATTAGC
AAAAATAATAGATTTTTCAGAAGATAAAGCTATTATGGTTAATAATGCAGATTGGCTTTTAAATTTAAATTACATAGAAT
TCTTAAGGGAAATAGGAGTTCATTTTTCTGTAAATAAAATGTTAACAGCAGAATGTTTTAAGAGTAGATTAGAAAAAGGG
TTATCTTTTTTAGAATTTAATTATATGTTAATGCAAGGTTATGATTTCTTAGAATTAAATAGAAAATATAACTGCGTTAT
GGAATTAGGTGGAGATGACCAATGGTCTAATATATTAGCAGGTGTAGATTTGATAAGAAGAAAAGAAAGCAAATCAGCCT
ATGGTATGACATTTACTCTCTTAACTAATAGTGAAGGAAAGAAAATGGGGAAAACAGAAAGTGGTGCCCTATGGTTAGAT
CCAGAAAAAACATCACCATATGAATTCTATCAATATTGGAGAAATGTAGCAGATGCAGATGTAGAAAAATGTTTACGTTT
AATAACTTTCTTACCAATGGATGAAGTTAGAAGACTTTCATCATTAGAAGGAGCAGAAATAAATGAAGCTAAAAAGGTTT
TAGCTTTTGAAGTTACTAAGCTTATACATGGAGAAGAAGAAGCTCAAAAAGCTAAAATTGCTGCGGAAGCTTTATTCGGT
GGAAATGCTAAAGATTTAGGAAATATGCCTACAGCTTATATAGATAAGAATGATTTAAATAATCTATTAGTAGATCTATT
GGCTAAGTGTGAAATATTCCCATCTAAGAGTGAAGCCAGAAGACTAATAAAGCAGGGTGGTCTTTATTTAAATGATGAGA
AAGTTACAGATATGAATTTAGTAGTAACAGAAGAACATGTGACAGAAGATGGAATAATGATTAGAAGAGGTAAAAAGAAT
TTTAACAGAATAGTTGTAGAGTAG

Upstream 100 bases:

>100_bases
TAAGATTTAAATTATGTAAAACATTGCTTATATGAATATTGATAAAATATAACTTTCAATATATACTAAAAAAAGGAACT
AATATTAGGAGGAATGAACA

Downstream 100 bases:

>100_bases
CGAATAAAAGAGGCTATCTTAAAATAGCTTTAATTTTAAAACCGTAAATATAAATAATATATTCATAAAGCACTTCATTT
TGCTAAGCGGTTCTAGATTT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSNVYDILKERGYIKQLTHEEEIRELLGKEKISFYIGFDPTADSLHVGHFLQMMVMAHMQKAGHRPIALVGGGTGMIGDP
TGKTDMRKMMTKEQIEHNCNCFKKQLAKIIDFSEDKAIMVNNADWLLNLNYIEFLREIGVHFSVNKMLTAECFKSRLEKG
LSFLEFNYMLMQGYDFLELNRKYNCVMELGGDDQWSNILAGVDLIRRKESKSAYGMTFTLLTNSEGKKMGKTESGALWLD
PEKTSPYEFYQYWRNVADADVEKCLRLITFLPMDEVRRLSSLEGAEINEAKKVLAFEVTKLIHGEEEAQKAKIAAEALFG
GNAKDLGNMPTAYIDKNDLNNLLVDLLAKCEIFPSKSEARRLIKQGGLYLNDEKVTDMNLVVTEEHVTEDGIMIRRGKKN
FNRIVVE

Sequences:

>Translated_407_residues
MSNVYDILKERGYIKQLTHEEEIRELLGKEKISFYIGFDPTADSLHVGHFLQMMVMAHMQKAGHRPIALVGGGTGMIGDP
TGKTDMRKMMTKEQIEHNCNCFKKQLAKIIDFSEDKAIMVNNADWLLNLNYIEFLREIGVHFSVNKMLTAECFKSRLEKG
LSFLEFNYMLMQGYDFLELNRKYNCVMELGGDDQWSNILAGVDLIRRKESKSAYGMTFTLLTNSEGKKMGKTESGALWLD
PEKTSPYEFYQYWRNVADADVEKCLRLITFLPMDEVRRLSSLEGAEINEAKKVLAFEVTKLIHGEEEAQKAKIAAEALFG
GNAKDLGNMPTAYIDKNDLNNLLVDLLAKCEIFPSKSEARRLIKQGGLYLNDEKVTDMNLVVTEEHVTEDGIMIRRGKKN
FNRIVVE
>Mature_406_residues
SNVYDILKERGYIKQLTHEEEIRELLGKEKISFYIGFDPTADSLHVGHFLQMMVMAHMQKAGHRPIALVGGGTGMIGDPT
GKTDMRKMMTKEQIEHNCNCFKKQLAKIIDFSEDKAIMVNNADWLLNLNYIEFLREIGVHFSVNKMLTAECFKSRLEKGL
SFLEFNYMLMQGYDFLELNRKYNCVMELGGDDQWSNILAGVDLIRRKESKSAYGMTFTLLTNSEGKKMGKTESGALWLDP
EKTSPYEFYQYWRNVADADVEKCLRLITFLPMDEVRRLSSLEGAEINEAKKVLAFEVTKLIHGEEEAQKAKIAAEALFGG
NAKDLGNMPTAYIDKNDLNNLLVDLLAKCEIFPSKSEARRLIKQGGLYLNDEKVTDMNLVVTEEHVTEDGIMIRRGKKNF
NRIVVE

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=427, Percent_Identity=33.2552693208431, Blast_Score=236, Evalue=3e-62,
Organism=Escherichia coli, GI1787925, Length=419, Percent_Identity=43.9140811455847, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25145802, Length=398, Percent_Identity=34.9246231155779, Blast_Score=217, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI25145805, Length=293, Percent_Identity=34.4709897610922, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325160, Length=434, Percent_Identity=31.7972350230415, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI20130383, Length=428, Percent_Identity=38.0841121495327, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46465; Mature: 46334

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVYDILKERGYIKQLTHEEEIRELLGKEKISFYIGFDPTADSLHVGHFLQMMVMAHMQ
CCHHHHHHHCCCHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KAGHRPIALVGGGTGMIGDPTGKTDMRKMMTKEQIEHNCNCFKKQLAKIIDFSEDKAIMV
HCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
NNADWLLNLNYIEFLREIGVHFSVNKMLTAECFKSRLEKGLSFLEFNYMLMQGYDFLELN
ECCCEEEECHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEECC
RKYNCVMELGGDDQWSNILAGVDLIRRKESKSAYGMTFTLLTNSEGKKMGKTESGALWLD
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEC
PEKTSPYEFYQYWRNVADADVEKCLRLITFLPMDEVRRLSSLEGAEINEAKKVLAFEVTK
CCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LIHGEEEAQKAKIAAEALFGGNAKDLGNMPTAYIDKNDLNNLLVDLLAKCEIFPSKSEAR
HHCCHHHHHHHHHHHHHHHCCCCHHHCCCCCEEECHHHHHHHHHHHHHHHCCCCCHHHHH
RLIKQGGLYLNDEKVTDMNLVVTEEHVTEDGIMIRRGKKNFNRIVVE
HHHHHCCCEECCCCCCCEEEEEECCCCCCCCEEEEECCCCCCEEECC
>Mature Secondary Structure 
SNVYDILKERGYIKQLTHEEEIRELLGKEKISFYIGFDPTADSLHVGHFLQMMVMAHMQ
CHHHHHHHCCCHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KAGHRPIALVGGGTGMIGDPTGKTDMRKMMTKEQIEHNCNCFKKQLAKIIDFSEDKAIMV
HCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
NNADWLLNLNYIEFLREIGVHFSVNKMLTAECFKSRLEKGLSFLEFNYMLMQGYDFLELN
ECCCEEEECHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEECC
RKYNCVMELGGDDQWSNILAGVDLIRRKESKSAYGMTFTLLTNSEGKKMGKTESGALWLD
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEC
PEKTSPYEFYQYWRNVADADVEKCLRLITFLPMDEVRRLSSLEGAEINEAKKVLAFEVTK
CCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LIHGEEEAQKAKIAAEALFGGNAKDLGNMPTAYIDKNDLNNLLVDLLAKCEIFPSKSEAR
HHCCHHHHHHHHHHHHHHHCCCCHHHCCCCCEEECHHHHHHHHHHHHHHHCCCCCHHHHH
RLIKQGGLYLNDEKVTDMNLVVTEEHVTEDGIMIRRGKKNFNRIVVE
HHHHHCCCEECCCCCCCEEEEEECCCCCCCCEEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA