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The map label for this gene is groEL

Identifier: 170756380

GI number: 170756380

Start: 3568959

End: 3570584

Strand: Reverse

Name: groEL

Synonym: CLD_1225

Alternate gene names: 170756380

Gene position: 3570584-3568959 (Counterclockwise)

Preceding gene: 170754876

Following gene: 170757052

Centisome position: 90.21

GC content: 33.33

Gene sequence:

>1626_bases
ATGGCAAAAAGTTTATTGTTTGGGGAACAAGCTAGAAGATCAATGGAAGCTGGTGTTGATAAGTTAGCTGATACAGTAAG
AGTAACACTTGGACCAAAAGGAAGAAATGTTGTTTTAGATAAAAAATTTGGCTCACCATTAATAACAAATGATGGTGTTA
CAATAGCAAGAGAAATAGAACTAGAAGATCCATATGAAAATATGGGAGCACAACTTGTAAAAGAAGTTGCAACTAAAACA
AATGATGTAGCAGGAGACGGCACTACTACGGCTACATTATTAGCTCAAGCTATAATAAGAGAAGGATTAAAAAATGTTAC
AGCAGGGGCTAACCCAATCCAAATAAGAACAGGGATAAGAAAAGCTGTAGAAAAGGCTGTAGAAGAAATAAAAGTTATTT
CTAAACCTGTAAATGGAAAAGAAGATATTGCTAGAGTTGCTGCTATATCAGCTGCAAGTGAAGAAGTAGGAAAACTTATT
GCAGATGCTATGGAAAGAGTAGGAAATGACGGAGTTATAACTGTAGAAGAATCAAAATCTATGGGAACTGACCTAGAAGT
AGTTGAAGGTATGCAATTTGATAGAGGATATGTAAGTGCATATATGGTAACTGACACTGAAAAAATGGAAGCAGTATTAG
ATGACGTATATATCTTAATAACTGATAAAAAAATATCCAACATACAAGAAATATTACCTATCTTAGAACAAATAGTTCAA
CAAGGTAAAAAATTATTAATAATAAGTGAAGACATAGAAGGAGAAGCCTTAAGCACATTAGTACTTAACAAGTTAAGAGG
AACATTTACTTGTGTAGGTGTAAAAGCACCAGGATTTGGAGATAGAAGAAAAGAAATGCTTCAAGATATAGCTATTTTAA
CAGGTGGTGAAGTTATTTCTGAAGAATTAGGAAGAGATTTAAAAGATGTTACTATAGATATGTTAGGAACAGCAGACAGT
GTGAAAGTTACTAAAGAAAATACTACAATAGTTAATGGTAAAGGCGATAAAGTAGCTATAAAAGAAAGAGTATCTCAAAT
AAGAGTACAAATTGAAGATACAACTTCAGAGTTTGATAAGGAAAAGCTTCAAGAAAGACTTGCTAAATTAGCAGGTGGAG
TTGCTGTTATAAGAGTTGGAGCAGCTACAGAAACTGAATTAAAAGAAGAAAAATTAAGAATAGAAGATGCTCTTGCAGCT
ACAAAAGCAGCAGTAGAAGAAGGAATAGTTCCAGGTGGCGGAACAGCATATATAGATATTATACCTAAAATTGCTGATTT
AACTTCTGATATTATAGATGTTAAATTAGGAATAGATATAATAAGAAAAGCTCTAGAAGAACCAGTAAGACAAATAGCTA
ATAATGCAGGTGCTGAGGGATCAGTAATAATTGAAAAAGTTAAAGCTACTGAAGCAGGCGTTGGATATGATGCTTTAAAT
GATAAATATGTAGATATGCTAAAGACTGGTATAGTTGATCCAACTAAGGTTACAAGATCAGCATTACAAAATGCAGCTTC
AATTGCATCTACTTTCTTAACAACAGAAGCTGCAGTAGCAGATATTCCAGAAAAAGAAAATACACCACCAATGGCGCCAG
GAATGGGAATGGATGGAATGTATTAA

Upstream 100 bases:

>100_bases
AAGTGAAAATTGAGGGCGAAGAAGTAACTATATTAAAGCAAGATGACATATTAGCAGTAGTTGAAGGTTAATTATATATT
TTATTTAGGAGGTATGAGAA

Downstream 100 bases:

>100_bases
TGAAAATAAAAATAAGAGACTCTTTATATAGAGTTTCTTATTTTTATTTTTGTAGTTAATATAATATCATTTTTATTATT
AAAAATGATTATCTCTTTGT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MAKSLLFGEQARRSMEAGVDKLADTVRVTLGPKGRNVVLDKKFGSPLITNDGVTIAREIELEDPYENMGAQLVKEVATKT
NDVAGDGTTTATLLAQAIIREGLKNVTAGANPIQIRTGIRKAVEKAVEEIKVISKPVNGKEDIARVAAISAASEEVGKLI
ADAMERVGNDGVITVEESKSMGTDLEVVEGMQFDRGYVSAYMVTDTEKMEAVLDDVYILITDKKISNIQEILPILEQIVQ
QGKKLLIISEDIEGEALSTLVLNKLRGTFTCVGVKAPGFGDRRKEMLQDIAILTGGEVISEELGRDLKDVTIDMLGTADS
VKVTKENTTIVNGKGDKVAIKERVSQIRVQIEDTTSEFDKEKLQERLAKLAGGVAVIRVGAATETELKEEKLRIEDALAA
TKAAVEEGIVPGGGTAYIDIIPKIADLTSDIIDVKLGIDIIRKALEEPVRQIANNAGAEGSVIIEKVKATEAGVGYDALN
DKYVDMLKTGIVDPTKVTRSALQNAASIASTFLTTEAAVADIPEKENTPPMAPGMGMDGMY

Sequences:

>Translated_541_residues
MAKSLLFGEQARRSMEAGVDKLADTVRVTLGPKGRNVVLDKKFGSPLITNDGVTIAREIELEDPYENMGAQLVKEVATKT
NDVAGDGTTTATLLAQAIIREGLKNVTAGANPIQIRTGIRKAVEKAVEEIKVISKPVNGKEDIARVAAISAASEEVGKLI
ADAMERVGNDGVITVEESKSMGTDLEVVEGMQFDRGYVSAYMVTDTEKMEAVLDDVYILITDKKISNIQEILPILEQIVQ
QGKKLLIISEDIEGEALSTLVLNKLRGTFTCVGVKAPGFGDRRKEMLQDIAILTGGEVISEELGRDLKDVTIDMLGTADS
VKVTKENTTIVNGKGDKVAIKERVSQIRVQIEDTTSEFDKEKLQERLAKLAGGVAVIRVGAATETELKEEKLRIEDALAA
TKAAVEEGIVPGGGTAYIDIIPKIADLTSDIIDVKLGIDIIRKALEEPVRQIANNAGAEGSVIIEKVKATEAGVGYDALN
DKYVDMLKTGIVDPTKVTRSALQNAASIASTFLTTEAAVADIPEKENTPPMAPGMGMDGMY
>Mature_540_residues
AKSLLFGEQARRSMEAGVDKLADTVRVTLGPKGRNVVLDKKFGSPLITNDGVTIAREIELEDPYENMGAQLVKEVATKTN
DVAGDGTTTATLLAQAIIREGLKNVTAGANPIQIRTGIRKAVEKAVEEIKVISKPVNGKEDIARVAAISAASEEVGKLIA
DAMERVGNDGVITVEESKSMGTDLEVVEGMQFDRGYVSAYMVTDTEKMEAVLDDVYILITDKKISNIQEILPILEQIVQQ
GKKLLIISEDIEGEALSTLVLNKLRGTFTCVGVKAPGFGDRRKEMLQDIAILTGGEVISEELGRDLKDVTIDMLGTADSV
KVTKENTTIVNGKGDKVAIKERVSQIRVQIEDTTSEFDKEKLQERLAKLAGGVAVIRVGAATETELKEEKLRIEDALAAT
KAAVEEGIVPGGGTAYIDIIPKIADLTSDIIDVKLGIDIIRKALEEPVRQIANNAGAEGSVIIEKVKATEAGVGYDALND
KYVDMLKTGIVDPTKVTRSALQNAASIASTFLTTEAAVADIPEKENTPPMAPGMGMDGMY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=50.7547169811321, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=50.7547169811321, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI38455427, Length=546, Percent_Identity=23.4432234432234, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI58331173, Length=549, Percent_Identity=23.1329690346084, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI302058290, Length=510, Percent_Identity=24.5098039215686, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI24307939, Length=191, Percent_Identity=28.7958115183246, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=59.1254752851711, Blast_Score=598, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=47.7272727272727, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI193210679, Length=236, Percent_Identity=44.9152542372881, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147750, Length=558, Percent_Identity=23.6559139784946, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25144674, Length=184, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532601, Length=166, Percent_Identity=30.1204819277108, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17564182, Length=549, Percent_Identity=22.040072859745, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.0534351145038, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322446, Length=189, Percent_Identity=31.7460317460317, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322524, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320058, Length=179, Percent_Identity=25.1396648044693, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=49.9051233396584, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=49.9051233396584, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=47.8178368121442, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=47.8178368121442, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=47.8178368121442, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17864606, Length=523, Percent_Identity=41.491395793499, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=35.5140186915888, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=35.5140186915888, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24645179, Length=507, Percent_Identity=23.0769230769231, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571140, Length=563, Percent_Identity=23.4458259325044, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI18858175, Length=563, Percent_Identity=23.4458259325044, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583944, Length=191, Percent_Identity=30.3664921465969, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647245, Length=173, Percent_Identity=26.5895953757225, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24652903, Length=173, Percent_Identity=26.5895953757225, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_CLOB1 (A7FYP3)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385616.1
- ProteinModelPortal:   A7FYP3
- SMR:   A7FYP3
- STRING:   A7FYP3
- GeneID:   5395293
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3354
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NKPETAT
- ProtClustDB:   PRK00013
- BioCyc:   CBOT441770:CLB_3354-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57923; Mature: 57792

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSLLFGEQARRSMEAGVDKLADTVRVTLGPKGRNVVLDKKFGSPLITNDGVTIAREIE
CCCCHHCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCEEECCCCEEEEEEE
LEDPYENMGAQLVKEVATKTNDVAGDGTTTATLLAQAIIREGLKNVTAGANPIQIRTGIR
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHH
KAVEKAVEEIKVISKPVNGKEDIARVAAISAASEEVGKLIADAMERVGNDGVITVEESKS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MGTDLEVVEGMQFDRGYVSAYMVTDTEKMEAVLDDVYILITDKKISNIQEILPILEQIVQ
CCCCHHHHCCCCCCCCEEEEEEEECHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHH
QGKKLLIISEDIEGEALSTLVLNKLRGTFTCVGVKAPGFGDRRKEMLQDIAILTGGEVIS
CCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGRDLKDVTIDMLGTADSVKVTKENTTIVNGKGDKVAIKERVSQIRVQIEDTTSEFDK
HHHCCCHHHHHHHHCCCCCCEEEEECCCEEECCCCCCHHHHHHHHHHEEEEECCHHHHHH
EKLQERLAKLAGGVAVIRVGAATETELKEEKLRIEDALAATKAAVEEGIVPGGGTAYIDI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
IPKIADLTSDIIDVKLGIDIIRKALEEPVRQIANNAGAEGSVIIEKVKATEAGVGYDALN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEHHHHHCCCCHHHCC
DKYVDMLKTGIVDPTKVTRSALQNAASIASTFLTTEAAVADIPEKENTPPMAPGMGMDGM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
Y
C
>Mature Secondary Structure 
AKSLLFGEQARRSMEAGVDKLADTVRVTLGPKGRNVVLDKKFGSPLITNDGVTIAREIE
CCCHHCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCEEECCCCEEEEEEE
LEDPYENMGAQLVKEVATKTNDVAGDGTTTATLLAQAIIREGLKNVTAGANPIQIRTGIR
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHH
KAVEKAVEEIKVISKPVNGKEDIARVAAISAASEEVGKLIADAMERVGNDGVITVEESKS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MGTDLEVVEGMQFDRGYVSAYMVTDTEKMEAVLDDVYILITDKKISNIQEILPILEQIVQ
CCCCHHHHCCCCCCCCEEEEEEEECHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHH
QGKKLLIISEDIEGEALSTLVLNKLRGTFTCVGVKAPGFGDRRKEMLQDIAILTGGEVIS
CCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGRDLKDVTIDMLGTADSVKVTKENTTIVNGKGDKVAIKERVSQIRVQIEDTTSEFDK
HHHCCCHHHHHHHHCCCCCCEEEEECCCEEECCCCCCHHHHHHHHHHEEEEECCHHHHHH
EKLQERLAKLAGGVAVIRVGAATETELKEEKLRIEDALAATKAAVEEGIVPGGGTAYIDI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
IPKIADLTSDIIDVKLGIDIIRKALEEPVRQIANNAGAEGSVIIEKVKATEAGVGYDALN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEHHHHHCCCCHHHCC
DKYVDMLKTGIVDPTKVTRSALQNAASIASTFLTTEAAVADIPEKENTPPMAPGMGMDGM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA