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The map label for this gene is phoR [H]

Identifier: 170754692

GI number: 170754692

Start: 415508

End: 417355

Strand: Direct

Name: phoR [H]

Synonym: CLD_0416

Alternate gene names: 170754692

Gene position: 415508-417355 (Clockwise)

Preceding gene: 170754310

Following gene: 170757808

Centisome position: 10.5

GC content: 24.35

Gene sequence:

>1848_bases
ATGAACTTAGATAAAATAGAAATTAGAAATTGGAGTCATGATAAAAAAATATATAATAGCATGTTAATAGTAAAATTCAT
TATACTGCTTTTTTGCGGAGGTGCTATTTATTTAGATTATGCAGAAAAGAATAATAAGAATATTTCTCAAAACTTTTATT
GTAATGCATTAAATCTAGTTATTATAATAACATGTTTAGTTAGTGTATATTTTATTTGGATGTTTATATCAATAAAGGCT
TTCAAATTTGAAAGAATAAAAACAATTCAAGTTATAGAAAATACTATATCAATTGTAATTTTTACATTTATAATAATGAT
GTCGGGAAGCTATAAGAGCTCTTATAAATTTCTATTTTTAGTAGCTATAATTACTTCTACAATACAATTGGGAATGAAAC
ATGGAATTATTACGTCACTTGTATCATCTATTATAATATTAGCCATAGATCTAATATTAGCACCAAAGGCTCCAGTAAAT
ATATATTTTGAAACAGATTTAATTTTAGTAGGAGTTTTCATAATGACAGCTTGGCCTCTGGGATATTATGTTAATATTCA
AAAGGAAGATCTAAGACAAAAAGAGGAAGAAGTAAATATATTAGCTAATAAATTAGACCAGAAAGAAATGCAAAAAAGAT
GTATGGAGCAATTACTTATAAAAAATGAAAATTGTTATAATTTACTTATAAGAAATTCAAAGGATGCTATATTGGTACAT
AGATATGGTAAGATTATATTTGCTAATGAAAGATTAAAGCAGATGTTAGGATACAAAAAAGAATATAATTTTGAGGATAT
AGATATAAAAAGTTTGATACCTGAAGATCAATATAATTTTGTAAAAGATCAATTGAAAAATTTATATAGCGGTAGTGAAG
ATATAGTTAAGTTTCAGCACAATGTAATTAATAATAAAGGAAAGACAATACAAAATACATCTACCTACGTTATATATGAT
GGAATACCAACAATTTTCAGCATATTACATGATGTAACATCTAAAATACAAGTAGAAAAACTTGAACAAGATGTTAAAAA
GAATATAGAATTGTTAAATGAAAGTAGAGAATACAATAAATTAATTACAGAGTTTTTATCTAATATATCTCATGAATTAA
AAACTCCCTTAAATGTTATTTTCACAGCAGTACAATTACTAGGATTTTATGAAGAAGATTGTAATGATGAAAAACAAGAT
AAATATTTAAAACTAATAAAGCAGAATTGTTATAGGCTTATGAAGTTAATAAATAACCTATTAGATACGACTAAACTAGA
TTCAGGATATTTAAAATTAAATTTAGTTAATTATAACATAGTAAATTTAATAGAGGAGATAACATTATCCGTAACATCCT
ATGCTGAAAGCAAGGGGATAAATATTATATTTGATACAAATGTGGAAGAGAAAATCATTGCTGTTGATACAGATAAAATA
GAAAGAATTATTTTAAATTTACTTTCTAATGCTATAAAGTTTACTAATCCCGGAGGTAATATATTTGTAAATGTAAAGGA
TTCTGGAGAAAATGTATATGTACATGTAAAAGACACAGGGGTTGGTATACCTTCGGATAAATTAGAATCTATATTTGAAA
GATTTTTTCAAGTAGATAAAACTTTAAAGAAAAATAAAGAAGGAACTGGTATAGGATTACATTTAGTAAAATCCTTTGTA
GAGATGCATAAAGGTACTGTTCATATAAAAAGTGAACTAGGACAAGGAACAGAATTTATAATAAAATTACCTTCTATAAT
TTGTGATGAGAATATAAAATCAAAAAATACAATTTATGAAGCTAATATAGAACGTATAAATATGGAATTTTCAGATATAA
ACCAATAG

Upstream 100 bases:

>100_bases
ATTTTATTCCCTCATTTACTTTATTTGTATTTAGTGTTTTTACTATGAACAAATTTATAAATAGAGAGGAATAATGTAAA
AATATATAGGAGTTATGTTA

Downstream 100 bases:

>100_bases
ATAATAATTATTTATAAAATAAATTTTTTAAAATTGTATACTACAATTTTAGAGAATTTATTTTATTTTTATTTATTAAA
ATTTATATAAGTTTACAAGT

Product: sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MNLDKIEIRNWSHDKKIYNSMLIVKFIILLFCGGAIYLDYAEKNNKNISQNFYCNALNLVIIITCLVSVYFIWMFISIKA
FKFERIKTIQVIENTISIVIFTFIIMMSGSYKSSYKFLFLVAIITSTIQLGMKHGIITSLVSSIIILAIDLILAPKAPVN
IYFETDLILVGVFIMTAWPLGYYVNIQKEDLRQKEEEVNILANKLDQKEMQKRCMEQLLIKNENCYNLLIRNSKDAILVH
RYGKIIFANERLKQMLGYKKEYNFEDIDIKSLIPEDQYNFVKDQLKNLYSGSEDIVKFQHNVINNKGKTIQNTSTYVIYD
GIPTIFSILHDVTSKIQVEKLEQDVKKNIELLNESREYNKLITEFLSNISHELKTPLNVIFTAVQLLGFYEEDCNDEKQD
KYLKLIKQNCYRLMKLINNLLDTTKLDSGYLKLNLVNYNIVNLIEEITLSVTSYAESKGINIIFDTNVEEKIIAVDTDKI
ERIILNLLSNAIKFTNPGGNIFVNVKDSGENVYVHVKDTGVGIPSDKLESIFERFFQVDKTLKKNKEGTGIGLHLVKSFV
EMHKGTVHIKSELGQGTEFIIKLPSIICDENIKSKNTIYEANIERINMEFSDINQ

Sequences:

>Translated_615_residues
MNLDKIEIRNWSHDKKIYNSMLIVKFIILLFCGGAIYLDYAEKNNKNISQNFYCNALNLVIIITCLVSVYFIWMFISIKA
FKFERIKTIQVIENTISIVIFTFIIMMSGSYKSSYKFLFLVAIITSTIQLGMKHGIITSLVSSIIILAIDLILAPKAPVN
IYFETDLILVGVFIMTAWPLGYYVNIQKEDLRQKEEEVNILANKLDQKEMQKRCMEQLLIKNENCYNLLIRNSKDAILVH
RYGKIIFANERLKQMLGYKKEYNFEDIDIKSLIPEDQYNFVKDQLKNLYSGSEDIVKFQHNVINNKGKTIQNTSTYVIYD
GIPTIFSILHDVTSKIQVEKLEQDVKKNIELLNESREYNKLITEFLSNISHELKTPLNVIFTAVQLLGFYEEDCNDEKQD
KYLKLIKQNCYRLMKLINNLLDTTKLDSGYLKLNLVNYNIVNLIEEITLSVTSYAESKGINIIFDTNVEEKIIAVDTDKI
ERIILNLLSNAIKFTNPGGNIFVNVKDSGENVYVHVKDTGVGIPSDKLESIFERFFQVDKTLKKNKEGTGIGLHLVKSFV
EMHKGTVHIKSELGQGTEFIIKLPSIICDENIKSKNTIYEANIERINMEFSDINQ
>Mature_615_residues
MNLDKIEIRNWSHDKKIYNSMLIVKFIILLFCGGAIYLDYAEKNNKNISQNFYCNALNLVIIITCLVSVYFIWMFISIKA
FKFERIKTIQVIENTISIVIFTFIIMMSGSYKSSYKFLFLVAIITSTIQLGMKHGIITSLVSSIIILAIDLILAPKAPVN
IYFETDLILVGVFIMTAWPLGYYVNIQKEDLRQKEEEVNILANKLDQKEMQKRCMEQLLIKNENCYNLLIRNSKDAILVH
RYGKIIFANERLKQMLGYKKEYNFEDIDIKSLIPEDQYNFVKDQLKNLYSGSEDIVKFQHNVINNKGKTIQNTSTYVIYD
GIPTIFSILHDVTSKIQVEKLEQDVKKNIELLNESREYNKLITEFLSNISHELKTPLNVIFTAVQLLGFYEEDCNDEKQD
KYLKLIKQNCYRLMKLINNLLDTTKLDSGYLKLNLVNYNIVNLIEEITLSVTSYAESKGINIIFDTNVEEKIIAVDTDKI
ERIILNLLSNAIKFTNPGGNIFVNVKDSGENVYVHVKDTGVGIPSDKLESIFERFFQVDKTLKKNKEGTGIGLHLVKSFV
EMHKGTVHIKSELGQGTEFIIKLPSIICDENIKSKNTIYEANIERINMEFSDINQ

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=30.6513409961686, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1789149, Length=275, Percent_Identity=29.8181818181818, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=31.8777292576419, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=30.0847457627119, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1786783, Length=256, Percent_Identity=29.296875, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=28.4, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=26.7716535433071, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081816, Length=255, Percent_Identity=28.6274509803922, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=30.2521008403361, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=23.7154150197628, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=25.6410256410256, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788549, Length=396, Percent_Identity=22.2222222222222, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790861, Length=243, Percent_Identity=27.5720164609054, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790346, Length=248, Percent_Identity=26.2096774193548, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790300, Length=232, Percent_Identity=26.2931034482759, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=27.9279279279279, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787374, Length=218, Percent_Identity=27.9816513761468, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=237, Percent_Identity=22.7848101265823, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=251, Percent_Identity=29.4820717131474, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 70960; Mature: 70960

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDKIEIRNWSHDKKIYNSMLIVKFIILLFCGGAIYLDYAEKNNKNISQNFYCNALNLV
CCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHH
IIITCLVSVYFIWMFISIKAFKFERIKTIQVIENTISIVIFTFIIMMSGSYKSSYKFLFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VAIITSTIQLGMKHGIITSLVSSIIILAIDLILAPKAPVNIYFETDLILVGVFIMTAWPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCC
GYYVNIQKEDLRQKEEEVNILANKLDQKEMQKRCMEQLLIKNENCYNLLIRNSKDAILVH
CEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEE
RYGKIIFANERLKQMLGYKKEYNFEDIDIKSLIPEDQYNFVKDQLKNLYSGSEDIVKFQH
ECCCEEEECHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
NVINNKGKTIQNTSTYVIYDGIPTIFSILHDVTSKIQVEKLEQDVKKNIELLNESREYNK
HHHCCCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LITEFLSNISHELKTPLNVIFTAVQLLGFYEEDCNDEKQDKYLKLIKQNCYRLMKLINNL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LDTTKLDSGYLKLNLVNYNIVNLIEEITLSVTSYAESKGINIIFDTNVEEKIIAVDTDKI
HHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECHHHH
ERIILNLLSNAIKFTNPGGNIFVNVKDSGENVYVHVKDTGVGIPSDKLESIFERFFQVDK
HHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
TLKKNKEGTGIGLHLVKSFVEMHKGTVHIKSELGQGTEFIIKLPSIICDENIKSKNTIYE
HHHCCCCCCCHHHHHHHHHHHHCCCCEEEEHHCCCCCCEEEECCHHHHCCCCCCCCCEEE
ANIERINMEFSDINQ
ECHHHEECCHHCCCC
>Mature Secondary Structure
MNLDKIEIRNWSHDKKIYNSMLIVKFIILLFCGGAIYLDYAEKNNKNISQNFYCNALNLV
CCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHH
IIITCLVSVYFIWMFISIKAFKFERIKTIQVIENTISIVIFTFIIMMSGSYKSSYKFLFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VAIITSTIQLGMKHGIITSLVSSIIILAIDLILAPKAPVNIYFETDLILVGVFIMTAWPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCC
GYYVNIQKEDLRQKEEEVNILANKLDQKEMQKRCMEQLLIKNENCYNLLIRNSKDAILVH
CEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEE
RYGKIIFANERLKQMLGYKKEYNFEDIDIKSLIPEDQYNFVKDQLKNLYSGSEDIVKFQH
ECCCEEEECHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
NVINNKGKTIQNTSTYVIYDGIPTIFSILHDVTSKIQVEKLEQDVKKNIELLNESREYNK
HHHCCCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LITEFLSNISHELKTPLNVIFTAVQLLGFYEEDCNDEKQDKYLKLIKQNCYRLMKLINNL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LDTTKLDSGYLKLNLVNYNIVNLIEEITLSVTSYAESKGINIIFDTNVEEKIIAVDTDKI
HHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECHHHH
ERIILNLLSNAIKFTNPGGNIFVNVKDSGENVYVHVKDTGVGIPSDKLESIFERFFQVDK
HHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
TLKKNKEGTGIGLHLVKSFVEMHKGTVHIKSELGQGTEFIIKLPSIICDENIKSKNTIYE
HHHCCCCCCCHHHHHHHHHHHHCCCCEEEEHHCCCCCCEEEECCHHHHCCCCCCCCCEEE
ANIERINMEFSDINQ
ECHHHEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]