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The map label for this gene is hemB [H]

Identifier: 170751999

GI number: 170751999

Start: 5961514

End: 5962572

Strand: Direct

Name: hemB [H]

Synonym: Mrad2831_5631

Alternate gene names: 170751999

Gene position: 5961514-5962572 (Clockwise)

Preceding gene: 170751996

Following gene: 170752000

Centisome position: 98.09

GC content: 70.44

Gene sequence:

>1059_bases
ATGTCAGACACCCTGCCAGAGCCGCGCCCTCTCGCCGTGGAGGCCGCCCGCGAGGGCGCCCGCGTGGAGGGTCTGAAGAT
TACCCAGCGCCCGCGCCGGAACCGGAAGGCCGACTGGTCGCGCCGCCTCGTCCGCGAGCACACCCTGACGGTCGACGACC
TGATCTGGCCGATGTTCGTGATCGACGGCGAGGGGCGCCGCGAGCCGGTCGCCTCGATGCCGGGCGTCGAGCGCCTCTCG
GTGGACGAGATCGTCCGCGACGCGGAGCGCGCCGCGAAGCTCGGCATCCCGGCGGTGTCGTTCTTTCCCTACACGGAGGT
GTCGCTGCGCGACCCGACCGGCTCGGAGGCGCTGAACGCCAACAACCTCGTCTGCCGGGCGGTCCGCGCCGTGAAGCGGG
CCGTGCCCGAGATCGGGATCATGACCGACGTGGCCCTCGATCCTTACACGAGCCACGGTCACGACGGCCTGATGAAGGAC
GGCGCGATCCTCAATGACGAGACCGTGGCGGTCCTCGTCGAGCAGAGTCTGATCCAGGCCGAGGCCGGGACCGATATCAT
CGCCCCCTCCGACATGATGGACGGGCGCGTCGGCGCGATCCGCGCCGGCCTCGACAAGGCCGGCTTCCTCGACGTGCAGA
TCATGGCGTACGCGGCCAAGTATGCCAGCGCCTTCTACGGGCCGTTCCGCGACGCGATCGGCACCAAGGCGGCCCTCGTG
GGCGACAAGCGCACCTACCAGATGGATCCGGGCAACTCGGCCGAAGCCCTGCGCGAGGTCCGGCTCGACCTCGACGAGGG
CGCGGATTCCGTGATGGTGAAGCCGGGCCTGCCCTACCTCGACATCATCCGCCGGGTCCGGGACGAGTTCCAGGTTCCGA
CCTTCGCCTACCAGGTGTCGGGCGAGTACGCGATGATCGAGGCGGCGGCCCGCAACGGCTGGCTCGACGGCGACCGCGCG
ATGATCGAGGCGCTCCTCGCCTTCAAGCGGGCCGGGGCCGACGGTGTGCTCACCTACCACGCGCCGCGGGTCGCGGAGCG
CCTGCGCAACCATCCGTGA

Upstream 100 bases:

>100_bases
CGGGTTTCGTTGCGCCAGCCCGGTGTGGTAGTCGGACGCCTCCGGCGCACGGGCGCCGCGCGATCCGCGGCGTGGTCCGC
GCGAACGGTAGCGAAGCCGC

Downstream 100 bases:

>100_bases
AGCGCGGGCACCGCTGGCTCCTCGGGGCGGCGGTCGTGGTCGGCTTCTTCGGCGGCCTCGCCGCCTGTCAGGACACCCTG
CGCCGGGATCGCGTCGCCAC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSDTLPEPRPLAVEAAREGARVEGLKITQRPRRNRKADWSRRLVREHTLTVDDLIWPMFVIDGEGRREPVASMPGVERLS
VDEIVRDAERAAKLGIPAVSFFPYTEVSLRDPTGSEALNANNLVCRAVRAVKRAVPEIGIMTDVALDPYTSHGHDGLMKD
GAILNDETVAVLVEQSLIQAEAGTDIIAPSDMMDGRVGAIRAGLDKAGFLDVQIMAYAAKYASAFYGPFRDAIGTKAALV
GDKRTYQMDPGNSAEALREVRLDLDEGADSVMVKPGLPYLDIIRRVRDEFQVPTFAYQVSGEYAMIEAAARNGWLDGDRA
MIEALLAFKRAGADGVLTYHAPRVAERLRNHP

Sequences:

>Translated_352_residues
MSDTLPEPRPLAVEAAREGARVEGLKITQRPRRNRKADWSRRLVREHTLTVDDLIWPMFVIDGEGRREPVASMPGVERLS
VDEIVRDAERAAKLGIPAVSFFPYTEVSLRDPTGSEALNANNLVCRAVRAVKRAVPEIGIMTDVALDPYTSHGHDGLMKD
GAILNDETVAVLVEQSLIQAEAGTDIIAPSDMMDGRVGAIRAGLDKAGFLDVQIMAYAAKYASAFYGPFRDAIGTKAALV
GDKRTYQMDPGNSAEALREVRLDLDEGADSVMVKPGLPYLDIIRRVRDEFQVPTFAYQVSGEYAMIEAAARNGWLDGDRA
MIEALLAFKRAGADGVLTYHAPRVAERLRNHP
>Mature_351_residues
SDTLPEPRPLAVEAAREGARVEGLKITQRPRRNRKADWSRRLVREHTLTVDDLIWPMFVIDGEGRREPVASMPGVERLSV
DEIVRDAERAAKLGIPAVSFFPYTEVSLRDPTGSEALNANNLVCRAVRAVKRAVPEIGIMTDVALDPYTSHGHDGLMKDG
AILNDETVAVLVEQSLIQAEAGTDIIAPSDMMDGRVGAIRAGLDKAGFLDVQIMAYAAKYASAFYGPFRDAIGTKAALVG
DKRTYQMDPGNSAEALREVRLDLDEGADSVMVKPGLPYLDIIRRVRDEFQVPTFAYQVSGEYAMIEAAARNGWLDGDRAM
IEALLAFKRAGADGVLTYHAPRVAERLRNHP

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Required for nodule development [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=42.156862745098, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI87081728, Length=321, Percent_Identity=46.1059190031153, Blast_Score=270, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321398, Length=312, Percent_Identity=35.8974358974359, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21358291, Length=291, Percent_Identity=39.8625429553265, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 38613; Mature: 38482

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLPEPRPLAVEAAREGARVEGLKITQRPRRNRKADWSRRLVREHTLTVDDLIWPMFV
CCCCCCCCCCCHHHHHHCCCEECCEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHCEEEE
IDGEGRREPVASMPGVERLSVDEIVRDAERAAKLGIPAVSFFPYTEVSLRDPTGSEALNA
ECCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCC
NNLVCRAVRAVKRAVPEIGIMTDVALDPYTSHGHDGLMKDGAILNDETVAVLVEQSLIQA
CHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHH
EAGTDIIAPSDMMDGRVGAIRAGLDKAGFLDVQIMAYAAKYASAFYGPFRDAIGTKAALV
HCCCCCCCCCHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GDKRTYQMDPGNSAEALREVRLDLDEGADSVMVKPGLPYLDIIRRVRDEFQVPTFAYQVS
CCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEEC
GEYAMIEAAARNGWLDGDRAMIEALLAFKRAGADGVLTYHAPRVAERLRNHP
CCEEEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCC
>Mature Secondary Structure 
SDTLPEPRPLAVEAAREGARVEGLKITQRPRRNRKADWSRRLVREHTLTVDDLIWPMFV
CCCCCCCCCCHHHHHHCCCEECCEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHCEEEE
IDGEGRREPVASMPGVERLSVDEIVRDAERAAKLGIPAVSFFPYTEVSLRDPTGSEALNA
ECCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCC
NNLVCRAVRAVKRAVPEIGIMTDVALDPYTSHGHDGLMKDGAILNDETVAVLVEQSLIQA
CHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHH
EAGTDIIAPSDMMDGRVGAIRAGLDKAGFLDVQIMAYAAKYASAFYGPFRDAIGTKAALV
HCCCCCCCCCHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GDKRTYQMDPGNSAEALREVRLDLDEGADSVMVKPGLPYLDIIRRVRDEFQVPTFAYQVS
CCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEEC
GEYAMIEAAARNGWLDGDRAMIEALLAFKRAGADGVLTYHAPRVAERLRNHP
CCEEEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226669; 12597275 [H]