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The map label for this gene is nadC [H]

Identifier: 170751833

GI number: 170751833

Start: 5776818

End: 5777690

Strand: Direct

Name: nadC [H]

Synonym: Mrad2831_5465

Alternate gene names: 170751833

Gene position: 5776818-5777690 (Clockwise)

Preceding gene: 170751832

Following gene: 170751834

Centisome position: 95.05

GC content: 73.88

Gene sequence:

>873_bases
ATGATTCAGTCGGTTCTCTCCGAAGAGATCCTTCCCCTGCCGCGGCTCCTCGTGGAGCCCGTGGTGCGCGCCGCCCTGCT
GGAGGATCTCGGCCGGGCCGGCGACATCACCACCGACGCCATCGTCCCGCCGGGCGAGCGGATGCGCGGCGTGATCGCCT
CGCGGCAGGACGGCGTCATCTCGGGCACCGACGCCGCCGCCATCGCCTTCGCGCTGGTGGACCCGGCCGTCACCGTCACG
GTCGAGCGCGGCGACGGCGCCCGCGTGGCGCCGGGCGACGTGGTGCTGCGTCTCGAAGGCCCGGCGCGGGCGATCCTCAC
GGCCGAGCGCGTGGCGCTGAACCTGCTCTGCCGGATGTCGGGCGTGGCCACCGCGACCCACGGCCTCGTCGAGGCCGCGC
GCCCGCACGGCAAGGCCTCGATCGTCTGCACCCGCAAGACCACGCCGGGCCTGCGCGCCCTGGAGAAGCACGCGGTCCGC
GCCGGCGGCGGCTCGAACCACCGCTTCGGCCTCGACGACGCGGTGCTGATCAAGGACAACCACGTGGCGGTGGCCGGCGG
CATCGTCCCGGCGATCGAGCGTGCCCGGTCCCGGGCCGGCCACCTGGTGAAGATCGAGTGCGAGGTCGACAGCCTGGAGC
AGCTGGAGGAGGCCCTCTCGGTCGGGGTCGACGCGGTGCTCCTCGACAATATGGGGCCGGACCGGCTCACCCGCGCGGTG
GCGATGATCGACGGTCGCGCCCTCGCCGAGGCGTCGGGCCGGATCACCCGCGAGACGGTGGGCGCCGTCGCAGCCTCGGG
CGTCGACCTGATCTCCTGCGGCTGGATCACCCATTCGGCGGCGATCATCGACCTGGGGCTCGACGCCGCCTGA

Upstream 100 bases:

>100_bases
ACTTCCCCCACCTCGCTCCGGCCGCGCACACCGAAGCGACGCTGTTTGACGCGATCGCCGCGCCCCGCGCGACTCCGTCC
ACCGAGGAGGTGCTGACGCC

Downstream 100 bases:

>100_bases
TCGGCGGGCCCCGCTCGCCACCGGCGCGGCGGGGCCGCCGCGGGCGTTCGACTGTCATCACGTTCGGGTGACGAGTGTTC
GTCGCGGTCGCTCGCGAGAT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MIQSVLSEEILPLPRLLVEPVVRAALLEDLGRAGDITTDAIVPPGERMRGVIASRQDGVISGTDAAAIAFALVDPAVTVT
VERGDGARVAPGDVVLRLEGPARAILTAERVALNLLCRMSGVATATHGLVEAARPHGKASIVCTRKTTPGLRALEKHAVR
AGGGSNHRFGLDDAVLIKDNHVAVAGGIVPAIERARSRAGHLVKIECEVDSLEQLEEALSVGVDAVLLDNMGPDRLTRAV
AMIDGRALAEASGRITRETVGAVAASGVDLISCGWITHSAAIIDLGLDAA

Sequences:

>Translated_290_residues
MIQSVLSEEILPLPRLLVEPVVRAALLEDLGRAGDITTDAIVPPGERMRGVIASRQDGVISGTDAAAIAFALVDPAVTVT
VERGDGARVAPGDVVLRLEGPARAILTAERVALNLLCRMSGVATATHGLVEAARPHGKASIVCTRKTTPGLRALEKHAVR
AGGGSNHRFGLDDAVLIKDNHVAVAGGIVPAIERARSRAGHLVKIECEVDSLEQLEEALSVGVDAVLLDNMGPDRLTRAV
AMIDGRALAEASGRITRETVGAVAASGVDLISCGWITHSAAIIDLGLDAA
>Mature_290_residues
MIQSVLSEEILPLPRLLVEPVVRAALLEDLGRAGDITTDAIVPPGERMRGVIASRQDGVISGTDAAAIAFALVDPAVTVT
VERGDGARVAPGDVVLRLEGPARAILTAERVALNLLCRMSGVATATHGLVEAARPHGKASIVCTRKTTPGLRALEKHAVR
AGGGSNHRFGLDDAVLIKDNHVAVAGGIVPAIERARSRAGHLVKIECEVDSLEQLEEALSVGVDAVLLDNMGPDRLTRAV
AMIDGRALAEASGRITRETVGAVAASGVDLISCGWITHSAAIIDLGLDAA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=35.2517985611511, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1786299, Length=284, Percent_Identity=37.6760563380282, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321162, Length=250, Percent_Identity=35.6, Blast_Score=149, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30009; Mature: 30009

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQSVLSEEILPLPRLLVEPVVRAALLEDLGRAGDITTDAIVPPGERMRGVIASRQDGVI
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCE
SGTDAAAIAFALVDPAVTVTVERGDGARVAPGDVVLRLEGPARAILTAERVALNLLCRMS
ECCCHHHHHHEEECCEEEEEEECCCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
GVATATHGLVEAARPHGKASIVCTRKTTPGLRALEKHAVRAGGGSNHRFGLDDAVLIKDN
CCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECC
HVAVAGGIVPAIERARSRAGHLVKIECEVDSLEQLEEALSVGVDAVLLDNMGPDRLTRAV
CEEEECCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
AMIDGRALAEASGRITRETVGAVAASGVDLISCGWITHSAAIIDLGLDAA
HHHCCHHHHHHCCCHHHHHHHHHHHCCCCEEEECCHHHCEEEEEECCCCC
>Mature Secondary Structure
MIQSVLSEEILPLPRLLVEPVVRAALLEDLGRAGDITTDAIVPPGERMRGVIASRQDGVI
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCE
SGTDAAAIAFALVDPAVTVTVERGDGARVAPGDVVLRLEGPARAILTAERVALNLLCRMS
ECCCHHHHHHEEECCEEEEEEECCCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
GVATATHGLVEAARPHGKASIVCTRKTTPGLRALEKHAVRAGGGSNHRFGLDDAVLIKDN
CCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECC
HVAVAGGIVPAIERARSRAGHLVKIECEVDSLEQLEEALSVGVDAVLLDNMGPDRLTRAV
CEEEECCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
AMIDGRALAEASGRITRETVGAVAASGVDLISCGWITHSAAIIDLGLDAA
HHHCCHHHHHHCCCHHHHHHHHHHHCCCCEEEECCHHHCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]