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The map label for this gene is nupX [H]

Identifier: 170751823

GI number: 170751823

Start: 5762887

End: 5764134

Strand: Direct

Name: nupX [H]

Synonym: Mrad2831_5453

Alternate gene names: 170751823

Gene position: 5762887-5764134 (Clockwise)

Preceding gene: 170751822

Following gene: 170751825

Centisome position: 94.82

GC content: 71.63

Gene sequence:

>1248_bases
ATGCTTGACCGCCTGACCCATGCCGGCCTCAGCCTCCTCGTGCTGCTCGCCGTCGCGTTCCTGTTCTCGACGAACCGGCG
GGCGATCAGTCCCCGCGTGGTCCTCACCGGCCTGGCTCTGCAGGTCGGCCTCGGCGCCCTGGTCCTGTTCCTGCCCGCCG
GCCAAGCCGCGCTGCGGGCCGCCGCCGCCGGAGTCGTCACCGTGCTGTCCTACGGCGACCGGGGCACGGCCTTCCTGTTC
GGCGGGCTCGTCGAGCCCAAGATGTTCGAGCTGTTCGGCGGCTCGGGCTTCATCCTGGCGCTGCGGGTCCTGCCGCAGAT
CCTCTACGTCTCCGCGCTGATCGGCGTGCTCTACCATCTCGGCGTGATGCAGGCGCTCGCCCGCTTGCTAGGCGCGGTGC
TCCGGCGGATCCTGGGCACGTCGCCGATCGAGTCGTTCTCCGCGGTGATCACGATCGCCATCGGCCAGAGCGAGATCGCC
GTCGCCCTGCGCCCGTTCCTCGCCCTGCTGACCGGGGCCGAGCTGTTCGCCGTCATGTCGAGCGGTGCCGCGTCCACCGC
GGGATCGATCCTGGCGGGCTACGCGGCGCTCGGCGTACCCATGACCTACCTGCTCGCGGCCTCCGTGATGGCGATCCCGG
GAGGGCTCGTCTACGCCAAGATCCTGATGCCCTCCACGGAGCCGACCCGGATCGCGACCACCCGGGTGGAGTTCGGCGAG
ACACGGGCGGCCAACATCATCGAGGCGGCGGCGGACGGCACCCAGAAGGGGCTCGCGGTGGCGGTCTCGGTGGGGGCCAT
GCTGATCGCCTTCGTCGGGCTGATCGCCCTGGCGGACGGCCTGTTCGGCACCCTCGGGGCTTGGATGGGCTACCCGTCCG
CCTCGTTCGAGGGCGTGCTCGGCCGGGCGCTCGCCCCGCTGGCGTGGCTCCTCGGCGTGCCCTGGGACCAGGCGACCCTG
GTCGGCGGCGCGATCGGCCAGAAGCTCGCCTTCAACGAGTTCCTGGCCTACGCCAACCTGTCGCCGGTCCTGAAGGCCGG
CACCCTCGAGCCGCGGGCGCAGGCGATCGTCTGCTTCGCCCTGTGCGGCTTCGCCAATTTCGCGTCGATCGCGATCCAGC
TCGCGAGCTTCTCGAGCCTCGTCCCGGAGCGGCGCTCCGAGGTCGCCCGGTACGGGCTGCGGGCGATCCTGGCGGGGACG
CTGTCGAACCTCACGAGCGCGGCGATCGCCGGGCTGTTCGTGGCGTGA

Upstream 100 bases:

>100_bases
CGACCTCTTCGCGCCCTATCTCGTGCCGGAAGGTCCCATCTGACGGCCCCTGGCCCGATCCTTCCATGCGCCCCGGCCAA
GCTCGGACCCGAAGGACGCG

Downstream 100 bases:

>100_bases
CGGATCAGGCGCCCTTGCGCGCCGCGAGAAGCAGCGCGTTCGGGCGGGTCCGCTTCGGCACCGGCAGGACGCGGTCGAGG
ATCGCGCCGACGCCGTACGC

Product: Na+ dependent nucleoside transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLDRLTHAGLSLLVLLAVAFLFSTNRRAISPRVVLTGLALQVGLGALVLFLPAGQAALRAAAAGVVTVLSYGDRGTAFLF
GGLVEPKMFELFGGSGFILALRVLPQILYVSALIGVLYHLGVMQALARLLGAVLRRILGTSPIESFSAVITIAIGQSEIA
VALRPFLALLTGAELFAVMSSGAASTAGSILAGYAALGVPMTYLLAASVMAIPGGLVYAKILMPSTEPTRIATTRVEFGE
TRAANIIEAAADGTQKGLAVAVSVGAMLIAFVGLIALADGLFGTLGAWMGYPSASFEGVLGRALAPLAWLLGVPWDQATL
VGGAIGQKLAFNEFLAYANLSPVLKAGTLEPRAQAIVCFALCGFANFASIAIQLASFSSLVPERRSEVARYGLRAILAGT
LSNLTSAAIAGLFVA

Sequences:

>Translated_415_residues
MLDRLTHAGLSLLVLLAVAFLFSTNRRAISPRVVLTGLALQVGLGALVLFLPAGQAALRAAAAGVVTVLSYGDRGTAFLF
GGLVEPKMFELFGGSGFILALRVLPQILYVSALIGVLYHLGVMQALARLLGAVLRRILGTSPIESFSAVITIAIGQSEIA
VALRPFLALLTGAELFAVMSSGAASTAGSILAGYAALGVPMTYLLAASVMAIPGGLVYAKILMPSTEPTRIATTRVEFGE
TRAANIIEAAADGTQKGLAVAVSVGAMLIAFVGLIALADGLFGTLGAWMGYPSASFEGVLGRALAPLAWLLGVPWDQATL
VGGAIGQKLAFNEFLAYANLSPVLKAGTLEPRAQAIVCFALCGFANFASIAIQLASFSSLVPERRSEVARYGLRAILAGT
LSNLTSAAIAGLFVA
>Mature_415_residues
MLDRLTHAGLSLLVLLAVAFLFSTNRRAISPRVVLTGLALQVGLGALVLFLPAGQAALRAAAAGVVTVLSYGDRGTAFLF
GGLVEPKMFELFGGSGFILALRVLPQILYVSALIGVLYHLGVMQALARLLGAVLRRILGTSPIESFSAVITIAIGQSEIA
VALRPFLALLTGAELFAVMSSGAASTAGSILAGYAALGVPMTYLLAASVMAIPGGLVYAKILMPSTEPTRIATTRVEFGE
TRAANIIEAAADGTQKGLAVAVSVGAMLIAFVGLIALADGLFGTLGAWMGYPSASFEGVLGRALAPLAWLLGVPWDQATL
VGGAIGQKLAFNEFLAYANLSPVLKAGTLEPRAQAIVCFALCGFANFASIAIQLASFSSLVPERRSEVARYGLRAILAGT
LSNLTSAAIAGLFVA

Specific function: Nucleoside transporter [H]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=417, Percent_Identity=34.052757793765, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI42542381, Length=417, Percent_Identity=34.2925659472422, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI227116277, Length=419, Percent_Identity=30.0715990453461, Blast_Score=205, Evalue=8e-53,
Organism=Escherichia coli, GI1788485, Length=406, Percent_Identity=51.4778325123153, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1788488, Length=404, Percent_Identity=51.4851485148515, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1788737, Length=414, Percent_Identity=31.8840579710145, Blast_Score=199, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17560276, Length=396, Percent_Identity=29.7979797979798, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71991794, Length=402, Percent_Identity=31.0945273631841, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25146537, Length=203, Percent_Identity=29.5566502463054, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45552517, Length=396, Percent_Identity=33.0808080808081, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI19921868, Length=396, Percent_Identity=33.0808080808081, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI45552519, Length=396, Percent_Identity=33.0808080808081, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI281360430, Length=397, Percent_Identity=30.9823677581864, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011642
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07670 Gate; PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 42624; Mature: 42624

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00669 GAS_VESICLE_A_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRLTHAGLSLLVLLAVAFLFSTNRRAISPRVVLTGLALQVGLGALVLFLPAGQAALRA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AAAGVVTVLSYGDRGTAFLFGGLVEPKMFELFGGSGFILALRVLPQILYVSALIGVLYHL
HHHHHHHHHHCCCCCCEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVMQALARLLGAVLRRILGTSPIESFSAVITIAIGQSEIAVALRPFLALLTGAELFAVMS
HHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
SGAASTAGSILAGYAALGVPMTYLLAASVMAIPGGLVYAKILMPSTEPTRIATTRVEFGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCCCCEEEEEEECCCC
TRAANIIEAAADGTQKGLAVAVSVGAMLIAFVGLIALADGLFGTLGAWMGYPSASFEGVL
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GRALAPLAWLLGVPWDQATLVGGAIGQKLAFNEFLAYANLSPVLKAGTLEPRAQAIVCFA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHH
LCGFANFASIAIQLASFSSLVPERRSEVARYGLRAILAGTLSNLTSAAIAGLFVA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDRLTHAGLSLLVLLAVAFLFSTNRRAISPRVVLTGLALQVGLGALVLFLPAGQAALRA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AAAGVVTVLSYGDRGTAFLFGGLVEPKMFELFGGSGFILALRVLPQILYVSALIGVLYHL
HHHHHHHHHHCCCCCCEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVMQALARLLGAVLRRILGTSPIESFSAVITIAIGQSEIAVALRPFLALLTGAELFAVMS
HHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
SGAASTAGSILAGYAALGVPMTYLLAASVMAIPGGLVYAKILMPSTEPTRIATTRVEFGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCCCCEEEEEEECCCC
TRAANIIEAAADGTQKGLAVAVSVGAMLIAFVGLIALADGLFGTLGAWMGYPSASFEGVL
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GRALAPLAWLLGVPWDQATLVGGAIGQKLAFNEFLAYANLSPVLKAGTLEPRAQAIVCFA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHH
LCGFANFASIAIQLASFSSLVPERRSEVARYGLRAILAGTLSNLTSAAIAGLFVA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]