Click here to switch to the map view.

The map label for this gene is guaD [H]

Identifier: 170751807

GI number: 170751807

Start: 5745427

End: 5745885

Strand: Direct

Name: guaD [H]

Synonym: Mrad2831_5437

Alternate gene names: 170751807

Gene position: 5745427-5745885 (Clockwise)

Preceding gene: 170751806

Following gene: 170751809

Centisome position: 94.53

GC content: 73.86

Gene sequence:

>459_bases
ATGTCGACGCACGAGGACCATATCCGCGAGGCGGTCGCCCTCGCCGCGGCCAATGTCGAGGCCGGCGGCGCGCCCTACGG
CGCGGTGATCGTGCGGGACGGCGCCGTGCTGGTCCGCGCGGCGAACACCGTGCACGCGACCAACGACCCGAGCGCCCATG
CCGAGATGGTGGCCCTGCGCGAGGCCAGCCGCCTGCTCGGCCGCCGCGACCTCGGCGACTGCGTGATGTACGCCAGCGGC
CGTCCGTGCCCGATGTGCCACGCGGCGATGCGGCTCGCGGGCTTCAAGGAGGGCTACTTCGCCTTCTCGGCCGAGGAGGC
CGAGACCTACGGTGCCGGCAGCGCGGCGATCTACGCCGAGCTGTGCCGACCCCTCGACGCGCAGCCGATGCGGGTCACCC
AGATCCGTCCGCCGGGCGATTCGCCTTACGCGGCCTGGAGGGCGTGCCGGGAGGCCTGA

Upstream 100 bases:

>100_bases
GACGATGCCCTACTGCACGGTGCGCTACGCGTTCTGAGCGCGGATGGCTGAACTTCCGGGCATGCGCGGCGTTGGCGCGC
CAGGGGAGGAAAGCTCAGCC

Downstream 100 bases:

>100_bases
CCCGGCCGCGCGGAGCTCAATGCGTCCAGGGGGCCGTGCGGTTGAACTTGAAATTGTCCGAGTACGACAGCCCCTTGCGG
TGGGCCGGCTTGGCCGGCTG

Product: zinc-binding CMP/dCMP deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MSTHEDHIREAVALAAANVEAGGAPYGAVIVRDGAVLVRAANTVHATNDPSAHAEMVALREASRLLGRRDLGDCVMYASG
RPCPMCHAAMRLAGFKEGYFAFSAEEAETYGAGSAAIYAELCRPLDAQPMRVTQIRPPGDSPYAAWRACREA

Sequences:

>Translated_152_residues
MSTHEDHIREAVALAAANVEAGGAPYGAVIVRDGAVLVRAANTVHATNDPSAHAEMVALREASRLLGRRDLGDCVMYASG
RPCPMCHAAMRLAGFKEGYFAFSAEEAETYGAGSAAIYAELCRPLDAQPMRVTQIRPPGDSPYAAWRACREA
>Mature_151_residues
STHEDHIREAVALAAANVEAGGAPYGAVIVRDGAVLVRAANTVHATNDPSAHAEMVALREASRLLGRRDLGDCVMYASGR
PCPMCHAAMRLAGFKEGYFAFSAEEAETYGAGSAAIYAELCRPLDAQPMRVTQIRPPGDSPYAAWRACREA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=112, Percent_Identity=34.8214285714286, Blast_Score=62, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555996, Length=123, Percent_Identity=39.8373983739837, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17554608, Length=143, Percent_Identity=31.4685314685315, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 16163; Mature: 16032

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHEDHIREAVALAAANVEAGGAPYGAVIVRDGAVLVRAANTVHATNDPSAHAEMVALR
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCEEECCCCCCHHHHHHHHH
EASRLLGRRDLGDCVMYASGRPCPMCHAAMRLAGFKEGYFAFSAEEAETYGAGSAAIYAE
HHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHCCCCHHHHHHH
LCRPLDAQPMRVTQIRPPGDSPYAAWRACREA
HHCCCCCCCEEEEEECCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STHEDHIREAVALAAANVEAGGAPYGAVIVRDGAVLVRAANTVHATNDPSAHAEMVALR
CCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCEEECCCCCCHHHHHHHHH
EASRLLGRRDLGDCVMYASGRPCPMCHAAMRLAGFKEGYFAFSAEEAETYGAGSAAIYAE
HHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHCCCCHHHHHHH
LCRPLDAQPMRVTQIRPPGDSPYAAWRACREA
HHCCCCCCCEEEEEECCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]