Click here to switch to the map view.

The map label for this gene is shc [H]

Identifier: 170751796

GI number: 170751796

Start: 5729843

End: 5731840

Strand: Direct

Name: shc [H]

Synonym: Mrad2831_5426

Alternate gene names: 170751796

Gene position: 5729843-5731840 (Clockwise)

Preceding gene: 170751795

Following gene: 170751797

Centisome position: 94.27

GC content: 70.07

Gene sequence:

>1998_bases
ATGAGAGAGGCCGTAAGCAAAGTCGAGGCGCTGCAGCGCTCCAAGACTCAGGGGATCTCGCTCGAGGACGTCGAGCGCGG
CGTGGCGCAGGCGACGCGCGCGCTGACCGCCCTGGCGCACGACGACGGGCACATCTGCTTCGAGCTCGAGGCGGATGCCA
CGATCCCGTCCGAGTACATCCTGTTCCACCATTTCCGCGGCACGCAGGTCCCCGGCGACCTCGAGGCCAAGATCGGCAAC
TACCTCCGCCGCACCCAGGGGCGGCACGGCGGATGGGCCCTCGTCCACGAGGGGCCGTTCGACATGAGCTGCACGGTCAA
GGCGTACTTCGCCCTCAAGATGATCGGCGACGATATCGAGGCGCCGCACATGCGCCGGGCGCGCGAGGGCATCCTGTCCC
GCGGCGGCGCGGCCAACGCCAACGTGTTCACCCGCTTCATGCTGGCGCTCTACGGCGAGGTGCCGTGGCGCGCCGTGCCG
GTGATGCCCGTCGAGGTGATGTTCCTGCCGAAGTGGTTCCCGTTCCACCTCGACAAGATCAGCTACTGGGCCCGCACCAC
CGTGGTGCCGCTGTTCGTGCTCCAGGCGACCAAGCCCCGGGCGCGCAACCCGCGCGGCATCAGCGTGCAGGAGCTGTTCG
TCACGCCGCCGGAGAGCGTCCGCTCCTGGCCGGGCTCCCCCCACGCCACGTGGCCGTGGACGCCGATCTTCGGCTTCATC
GACCGGGTGCTGCAGCGGGTCGAGAATCACCTGCCGCGCAAGAGCCGGCAGCGCGCCATGGAGATGGCCCGCGCCTGGGT
GAGCGAGCGCCTCAACGGCGAGGACGGCCTGGGCGCTATCTTCCCCGCGATGGTCAACTCGGTGCTGATGTACGAGGTGA
TGGGCTACCGGCCCGATCACCCGCAGGTGCGCGTCGCCTGCGACGCGATCGAGAAGCTCGTGGTCGAGAAGGCCGACGAG
GCCTACGTCCAGCCCTGCGTCTCGCCGGTCTGGGACACGGCGCTCGCGAGCCACGCGCTGCTCGAGGCGGGCGGCCCCGA
GGCCGAGGCCCAGGCCCGCGCCGGTCTGGACTGGCTGAAGCCCCGCCAGGTGCTCGACATCGTCGGTGACTGGGCGGCGC
GCAAGCCGAAGGTCCGGCCGGGCGGCTGGGCGTTCCAGTACGCCAACGCGCACTATCCCGACCTCGACGACACCGCCGTG
GTGGTGATGGCGATGGACCGGGCCATGCACCAGCACGGCCTCGTCGCCGGCATGCCGGACTACAAGGCCTCGATCGCCCG
CGCCCGCGAGTGGGTCGAGGGGCTGCAGTCGGAGGACGGTGGCTGGGCGGCGTTCGACGCCGACAACAACCACATGTACC
TCAACCACATCCCGTTCTCGGATCACGGCGCGCTGCTCGATCCGCCGACCGCGGACGTGACCGCCCGCGTGGTCGGGATG
CTGTCCCAGCTCGGCGAGACCCGGGAGACCTCCCGCGCCCTCGACCGCGGCGTGAACTACCTCCTGAACGACCAGGAGGA
GGACGGCTCGTGGTACGGCCGCTGGGGCATGAACTTCATCTACGGCACGTGGTCGGTGCTCTGCGCCCTCAACGCCGCCG
GGGTGGACCCGGCCGATCCGCGCATCCAGAAGGCCGTGTCCTGGCTGATCCGGATCCAGAACCCGGATGGCGGCTGGGGC
GAGGACGCCTCCTCGTACAAGATCGACCCGGCCTTCGAGCCCGGCTCGTCCACCGCTTCGCAGACCGCCTGGGCGCTGCT
CGCCCTAATGGCGGCCGGCGCGGTCGATGACCCGGCCGTGACCCGGGGCATCAACTTCCTGACCCGCACGCAGGGCGCGG
ACGGATTCTGGAAGGAGGAGCGCTACACCGCCACGGGCTTCCCGCGGGTGTTCTACCTGCGGTACCATGGCTACCCGAAG
TTCTTCCCGCTCTGGGCGATGGCGCGCTTCCGCAACCTCAAGCGTGGCAACAGCCGGCGCGTCCAGTTCGGCATGTGA

Upstream 100 bases:

>100_bases
TTCCTTGCGTGCGGGATCTGTCGTGCGCGCTGGAACCCAGGTGCGCGGCGCAGCTTGAGGCATGGCGTCCGCCGCGAGGC
GGTCGTTCGAGGCGAGGACT

Downstream 100 bases:

>100_bases
CGTCCGCCGACGTCCTGGGGCCGGCCCGGCGGGCCGGCTCCGCTCCGCCGGATCGCAGCGCGTTCGACCGTCCCGACAGC
CGATCCGCGAGCCCCGGTAC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MREAVSKVEALQRSKTQGISLEDVERGVAQATRALTALAHDDGHICFELEADATIPSEYILFHHFRGTQVPGDLEAKIGN
YLRRTQGRHGGWALVHEGPFDMSCTVKAYFALKMIGDDIEAPHMRRAREGILSRGGAANANVFTRFMLALYGEVPWRAVP
VMPVEVMFLPKWFPFHLDKISYWARTTVVPLFVLQATKPRARNPRGISVQELFVTPPESVRSWPGSPHATWPWTPIFGFI
DRVLQRVENHLPRKSRQRAMEMARAWVSERLNGEDGLGAIFPAMVNSVLMYEVMGYRPDHPQVRVACDAIEKLVVEKADE
AYVQPCVSPVWDTALASHALLEAGGPEAEAQARAGLDWLKPRQVLDIVGDWAARKPKVRPGGWAFQYANAHYPDLDDTAV
VVMAMDRAMHQHGLVAGMPDYKASIARAREWVEGLQSEDGGWAAFDADNNHMYLNHIPFSDHGALLDPPTADVTARVVGM
LSQLGETRETSRALDRGVNYLLNDQEEDGSWYGRWGMNFIYGTWSVLCALNAAGVDPADPRIQKAVSWLIRIQNPDGGWG
EDASSYKIDPAFEPGSSTASQTAWALLALMAAGAVDDPAVTRGINFLTRTQGADGFWKEERYTATGFPRVFYLRYHGYPK
FFPLWAMARFRNLKRGNSRRVQFGM

Sequences:

>Translated_665_residues
MREAVSKVEALQRSKTQGISLEDVERGVAQATRALTALAHDDGHICFELEADATIPSEYILFHHFRGTQVPGDLEAKIGN
YLRRTQGRHGGWALVHEGPFDMSCTVKAYFALKMIGDDIEAPHMRRAREGILSRGGAANANVFTRFMLALYGEVPWRAVP
VMPVEVMFLPKWFPFHLDKISYWARTTVVPLFVLQATKPRARNPRGISVQELFVTPPESVRSWPGSPHATWPWTPIFGFI
DRVLQRVENHLPRKSRQRAMEMARAWVSERLNGEDGLGAIFPAMVNSVLMYEVMGYRPDHPQVRVACDAIEKLVVEKADE
AYVQPCVSPVWDTALASHALLEAGGPEAEAQARAGLDWLKPRQVLDIVGDWAARKPKVRPGGWAFQYANAHYPDLDDTAV
VVMAMDRAMHQHGLVAGMPDYKASIARAREWVEGLQSEDGGWAAFDADNNHMYLNHIPFSDHGALLDPPTADVTARVVGM
LSQLGETRETSRALDRGVNYLLNDQEEDGSWYGRWGMNFIYGTWSVLCALNAAGVDPADPRIQKAVSWLIRIQNPDGGWG
EDASSYKIDPAFEPGSSTASQTAWALLALMAAGAVDDPAVTRGINFLTRTQGADGFWKEERYTATGFPRVFYLRYHGYPK
FFPLWAMARFRNLKRGNSRRVQFGM
>Mature_665_residues
MREAVSKVEALQRSKTQGISLEDVERGVAQATRALTALAHDDGHICFELEADATIPSEYILFHHFRGTQVPGDLEAKIGN
YLRRTQGRHGGWALVHEGPFDMSCTVKAYFALKMIGDDIEAPHMRRAREGILSRGGAANANVFTRFMLALYGEVPWRAVP
VMPVEVMFLPKWFPFHLDKISYWARTTVVPLFVLQATKPRARNPRGISVQELFVTPPESVRSWPGSPHATWPWTPIFGFI
DRVLQRVENHLPRKSRQRAMEMARAWVSERLNGEDGLGAIFPAMVNSVLMYEVMGYRPDHPQVRVACDAIEKLVVEKADE
AYVQPCVSPVWDTALASHALLEAGGPEAEAQARAGLDWLKPRQVLDIVGDWAARKPKVRPGGWAFQYANAHYPDLDDTAV
VVMAMDRAMHQHGLVAGMPDYKASIARAREWVEGLQSEDGGWAAFDADNNHMYLNHIPFSDHGALLDPPTADVTARVVGM
LSQLGETRETSRALDRGVNYLLNDQEEDGSWYGRWGMNFIYGTWSVLCALNAAGVDPADPRIQKAVSWLIRIQNPDGGWG
EDASSYKIDPAFEPGSSTASQTAWALLALMAAGAVDDPAVTRGINFLTRTQGADGFWKEERYTATGFPRVFYLRYHGYPK
FFPLWAMARFRNLKRGNSRRVQFGM

Specific function: Catalyzes the cyclization of squalene into hopene. Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=660, Percent_Identity=25.9090909090909, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI47933397, Length=660, Percent_Identity=25.9090909090909, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI224177558, Length=651, Percent_Identity=26.1136712749616, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI224177556, Length=660, Percent_Identity=25, Blast_Score=162, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6321863, Length=642, Percent_Identity=22.2741433021807, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 74336; Mature: 74336

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS01074 TERPENE_SYNTHASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVSKVEALQRSKTQGISLEDVERGVAQATRALTALAHDDGHICFELEADATIPSEYI
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEE
LFHHFRGTQVPGDLEAKIGNYLRRTQGRHGGWALVHEGPFDMSCTVKAYFALKMIGDDIE
EEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEHHHHHHHHHHHCCCCC
APHMRRAREGILSRGGAANANVFTRFMLALYGEVPWRAVPVMPVEVMFLPKWFPFHLDKI
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCCHHHHHH
SYWARTTVVPLFVLQATKPRARNPRGISVQELFVTPPESVRSWPGSPHATWPWTPIFGFI
HHHHHHHHHHHHEEECCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCCHHHHHH
DRVLQRVENHLPRKSRQRAMEMARAWVSERLNGEDGLGAIFPAMVNSVLMYEVMGYRPDH
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PQVRVACDAIEKLVVEKADEAYVQPCVSPVWDTALASHALLEAGGPEAEAQARAGLDWLK
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCC
PRQVLDIVGDWAARKPKVRPGGWAFQYANAHYPDLDDTAVVVMAMDRAMHQHGLVAGMPD
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCH
YKASIARAREWVEGLQSEDGGWAAFDADNNHMYLNHIPFSDHGALLDPPTADVTARVVGM
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
LSQLGETRETSRALDRGVNYLLNDQEEDGSWYGRWGMNFIYGTWSVLCALNAAGVDPADP
HHHHCCHHHHHHHHHHCCHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCH
RIQKAVSWLIRIQNPDGGWGEDASSYKIDPAFEPGSSTASQTAWALLALMAAGAVDDPAV
HHHHHHHHHEEEECCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
TRGINFLTRTQGADGFWKEERYTATGFPRVFYLRYHGYPKFFPLWAMARFRNLKRGNSRR
HHCCHHHHCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCE
VQFGM
EEECC
>Mature Secondary Structure
MREAVSKVEALQRSKTQGISLEDVERGVAQATRALTALAHDDGHICFELEADATIPSEYI
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEE
LFHHFRGTQVPGDLEAKIGNYLRRTQGRHGGWALVHEGPFDMSCTVKAYFALKMIGDDIE
EEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEHHHHHHHHHHHCCCCC
APHMRRAREGILSRGGAANANVFTRFMLALYGEVPWRAVPVMPVEVMFLPKWFPFHLDKI
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCCHHHHHH
SYWARTTVVPLFVLQATKPRARNPRGISVQELFVTPPESVRSWPGSPHATWPWTPIFGFI
HHHHHHHHHHHHEEECCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCCHHHHHH
DRVLQRVENHLPRKSRQRAMEMARAWVSERLNGEDGLGAIFPAMVNSVLMYEVMGYRPDH
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PQVRVACDAIEKLVVEKADEAYVQPCVSPVWDTALASHALLEAGGPEAEAQARAGLDWLK
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCC
PRQVLDIVGDWAARKPKVRPGGWAFQYANAHYPDLDDTAVVVMAMDRAMHQHGLVAGMPD
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCH
YKASIARAREWVEGLQSEDGGWAAFDADNNHMYLNHIPFSDHGALLDPPTADVTARVVGM
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
LSQLGETRETSRALDRGVNYLLNDQEEDGSWYGRWGMNFIYGTWSVLCALNAAGVDPADP
HHHHCCHHHHHHHHHHCCHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCH
RIQKAVSWLIRIQNPDGGWGEDASSYKIDPAFEPGSSTASQTAWALLALMAAGAVDDPAV
HHHHHHHHHEEEECCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
TRGINFLTRTQGADGFWKEERYTATGFPRVFYLRYHGYPKFFPLWAMARFRNLKRGNSRR
HHCCHHHHCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCE
VQFGM
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]