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The map label for this gene is qor [C]

Identifier: 170751654

GI number: 170751654

Start: 5599191

End: 5600213

Strand: Direct

Name: qor [C]

Synonym: Mrad2831_5281

Alternate gene names: 170751654

Gene position: 5599191-5600213 (Clockwise)

Preceding gene: 170751653

Following gene: 170751656

Centisome position: 92.12

GC content: 68.72

Gene sequence:

>1023_bases
ATGCGTGGCGTTACCTACACCGAAGGCGCCCAGATCGATGCGCCGGACGCCCTCCTCGACACCACCTTTCCCGATCCCGT
GCCGGTTGGGCGCGACCTGCTCGTACGCGTGCAGGCCATTTCCGTGAACCCAATCGACACCAAGGTGCGCCAAGGCGCCT
ACAAGCAGGGTTGCGAGCCGAAGGTTCTCGGCTGGGATGCGGCCGGAACCGTGGTCTCGGTCGGACCGGAGGCGCGCCTG
TTCAAGCCCGGCGACGCGGTGTTCTATGCCGGTGCGCTCGACCGGCCAGGTAGCAACGCCGCGTTCCAGTGCGTGGACGA
GCGCCTCGTCGGTGCCAAGCCAGCCAGCCTCGATTTCGCCGCCGCCGCGGCGCTACCGCTTACCGCGCTGACCGCTTGGG
AGATGTTGTTCGACCGGCTCGACGTAGCCACGCCCGTTCCGGGTGCCGCCCCCGCGATCCTGATCGTCGGCGGCGCCGGC
GGCGTCGGCTCGATCGCGATCCAGCTCGCCCGGCAGCTCACGGATCTCATCGTGATCGCTACGGCCTCGCGCCCCGAGAC
GGCGCAATGGTGCCGGGACCTCGGCGCCCACCACGTGATCGACCATGCGAAGCCCCTCGCCACCGAGGTGGCGGCGCTCG
GTCTTCCTGGGGCGCCCGGGTTCGTGTTCGCGACGACGCAGACCGGTGCGCATCTCCCGCAGATCATCGAGCTCCTCGCG
CCACAGGGTCGCCTCGGCCCGATCGACGATCCCGAGACCCTGGACGTGATGCCGCTCAAGCCCAAGAGCCTGTCGCTGCA
CTGGGAGCTGATGTTCACCCGCTCGCTGTTTCAGACCGCCGACATGGAACGGCAGCACGCGATCCTGACCGAGATCGCCC
GCCTCATCGATGCGGGACGGCTGCGCACGACGTTGAGCGAGACCTTCGGTCCGATCAACGCCGCCAACCTGGCACGCGCC
CACGCGCTCATCGAGAGCGGGAAGGCGAGGGGCAAGGTCGTCCTCGCTGGGTTCAGCGACTAA

Upstream 100 bases:

>100_bases
ATGTGCGCGTCACGCCGCTGCGCCGAAGGAAGCAGCACGCTATGAGACGGTCTGGGACGGCGGCGCGGCGCCGTCCGTCG
CGACATCCTGGGAGACACCC

Downstream 100 bases:

>100_bases
GCCGGCACGCGAAGCGTCCCGGCTCGGAGCTGGGACGCCGGTCGAGCTTGCCCCGGTCCCGGCCGTTCAGGACAATGGAA
GCGCCCTCCGACGCAAACCG

Product: zinc-binding alcohol dehydrogenase family protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRGVTYTEGAQIDAPDALLDTTFPDPVPVGRDLLVRVQAISVNPIDTKVRQGAYKQGCEPKVLGWDAAGTVVSVGPEARL
FKPGDAVFYAGALDRPGSNAAFQCVDERLVGAKPASLDFAAAAALPLTALTAWEMLFDRLDVATPVPGAAPAILIVGGAG
GVGSIAIQLARQLTDLIVIATASRPETAQWCRDLGAHHVIDHAKPLATEVAALGLPGAPGFVFATTQTGAHLPQIIELLA
PQGRLGPIDDPETLDVMPLKPKSLSLHWELMFTRSLFQTADMERQHAILTEIARLIDAGRLRTTLSETFGPINAANLARA
HALIESGKARGKVVLAGFSD

Sequences:

>Translated_340_residues
MRGVTYTEGAQIDAPDALLDTTFPDPVPVGRDLLVRVQAISVNPIDTKVRQGAYKQGCEPKVLGWDAAGTVVSVGPEARL
FKPGDAVFYAGALDRPGSNAAFQCVDERLVGAKPASLDFAAAAALPLTALTAWEMLFDRLDVATPVPGAAPAILIVGGAG
GVGSIAIQLARQLTDLIVIATASRPETAQWCRDLGAHHVIDHAKPLATEVAALGLPGAPGFVFATTQTGAHLPQIIELLA
PQGRLGPIDDPETLDVMPLKPKSLSLHWELMFTRSLFQTADMERQHAILTEIARLIDAGRLRTTLSETFGPINAANLARA
HALIESGKARGKVVLAGFSD
>Mature_340_residues
MRGVTYTEGAQIDAPDALLDTTFPDPVPVGRDLLVRVQAISVNPIDTKVRQGAYKQGCEPKVLGWDAAGTVVSVGPEARL
FKPGDAVFYAGALDRPGSNAAFQCVDERLVGAKPASLDFAAAAALPLTALTAWEMLFDRLDVATPVPGAAPAILIVGGAG
GVGSIAIQLARQLTDLIVIATASRPETAQWCRDLGAHHVIDHAKPLATEVAALGLPGAPGFVFATTQTGAHLPQIIELLA
PQGRLGPIDDPETLDVMPLKPKSLSLHWELMFTRSLFQTADMERQHAILTEIARLIDAGRLRTTLSETFGPINAANLARA
HALIESGKARGKVVLAGFSD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=335, Percent_Identity=31.044776119403, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI194239674, Length=334, Percent_Identity=26.0479041916168, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI13236495, Length=334, Percent_Identity=26.0479041916168, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI194239676, Length=194, Percent_Identity=31.9587628865979, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI22538446, Length=348, Percent_Identity=27.0114942528736, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22538444, Length=348, Percent_Identity=27.0114942528736, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790485, Length=188, Percent_Identity=31.3829787234043, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507255, Length=243, Percent_Identity=31.2757201646091, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71987554, Length=177, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35790; Mature: 35790

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGVTYTEGAQIDAPDALLDTTFPDPVPVGRDLLVRVQAISVNPIDTKVRQGAYKQGCEP
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHCHHHCCCCC
KVLGWDAAGTVVSVGPEARLFKPGDAVFYAGALDRPGSNAAFQCVDERLVGAKPASLDFA
CEEEECCCCCEEEECCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHH
AAAALPLTALTAWEMLFDRLDVATPVPGAAPAILIVGGAGGVGSIAIQLARQLTDLIVIA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEE
TASRPETAQWCRDLGAHHVIDHAKPLATEVAALGLPGAPGFVFATTQTGAHLPQIIELLA
ECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHC
PQGRLGPIDDPETLDVMPLKPKSLSLHWELMFTRSLFQTADMERQHAILTEIARLIDAGR
CCCCCCCCCCCCCEEEEECCCCCEEEEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
LRTTLSETFGPINAANLARAHALIESGKARGKVVLAGFSD
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCC
>Mature Secondary Structure
MRGVTYTEGAQIDAPDALLDTTFPDPVPVGRDLLVRVQAISVNPIDTKVRQGAYKQGCEP
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHCHHHCCCCC
KVLGWDAAGTVVSVGPEARLFKPGDAVFYAGALDRPGSNAAFQCVDERLVGAKPASLDFA
CEEEECCCCCEEEECCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHH
AAAALPLTALTAWEMLFDRLDVATPVPGAAPAILIVGGAGGVGSIAIQLARQLTDLIVIA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEE
TASRPETAQWCRDLGAHHVIDHAKPLATEVAALGLPGAPGFVFATTQTGAHLPQIIELLA
ECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHC
PQGRLGPIDDPETLDVMPLKPKSLSLHWELMFTRSLFQTADMERQHAILTEIARLIDAGR
CCCCCCCCCCCCCEEEEECCCCCEEEEEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
LRTTLSETFGPINAANLARAHALIESGKARGKVVLAGFSD
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]