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The map label for this gene is ptxR [H]

Identifier: 170751628

GI number: 170751628

Start: 5575469

End: 5576416

Strand: Direct

Name: ptxR [H]

Synonym: Mrad2831_5254

Alternate gene names: 170751628

Gene position: 5575469-5576416 (Clockwise)

Preceding gene: 170751623

Following gene: 170751630

Centisome position: 91.73

GC content: 72.05

Gene sequence:

>948_bases
ATGGTTGCGAAAACGGAAACCTTTGGCGGCGGATTGGACGACCTTCGCGCCTTCTGCGCGGTCGTCGACCTCGGCACAGT
CACGGCCGCCGCGGCGAGCCGGGGCGAGACCAAGGGCAGCCTCAGCCGACGCATCTCGCGCCTGGAGGCCGCGCTCGGCG
CCATCCTGATAGCCCGCCATCCCCGCGCGGTGTCGCCGACCGCGGAGGGCCTGGCCTTCTATGCCAAGGTGCAGGAGAGC
CTCGCGCTCCTCGACGAGGCGGCCGAGACCGCGCGTGACGCCCGCACCGTTCCTGCGGGCCACCTTCGCGTGACGACCTC
GGTCGACTTCGGCATCGAGCTGATGCCGGGGATCGTCGCGAGCTTCCGCCGGGCCTACCCGCAGATCACGGTCGATATGA
TCAACACGGACGCGCGGCTCGACCTCGCGGCCAACCGGATCGATCTCGCCCTGCGCCTGGGCGATGTGGAGGAGACCGGC
TACAGGGCCGCGCTGATCCTGCGTCTCTGGGTCGGGCTCTACGCGGCGCCGGACTACCTCGCGCGGCGTCCGGCGCCGAC
GAGCCTCGCGGCCCTGCCTGAGCACGACCTGATCCTCTCGCGCGAGAGGCCCGGGGCGCTGGGCATCATGCTCAGCGACG
GCCAGGGCCGGACGGAACAGGTGGCGCTCAGCCCTGCCGTCCGGGCGAGCGACTTCGCCGCGGTGCTCCGGCTGACGCTG
GCCGGGACAGGCATCGGCCATCTGCCGAGCGCCGTGGCGGCCGGCTCCGTCGCGAACGGGGCGCTCGTACGGGTGCTGGC
ACCTTGGGCGACGGCGGGCGGGGCGCTCCGGGCCGTGAGCCTCGCTGGCCGGGAATTGCCGGCACGTGTGCGCGTCTTTC
GCGAGCACGTTCGCTCCGAGATGATGAAGCGCTTCGCCGTCGAGCCGGACCAAGCCGAAGGCACCTGA

Upstream 100 bases:

>100_bases
AAACGGGCGACCCGACCCACCTGGGGGAAGGGCCGCGAGAGCCGAGGCCGGTGAGATACCCACGTTGGCGGCCGAGGTTG
AGCCTGCTATTCGGAACCAC

Downstream 100 bases:

>100_bases
TGCGAGCGGTTCTCAGGGACGTTCCTCGGCCGTCGAGCAGCGTCGGCGCAGGGTGGAGGCTGTGTGGAACGGCGCCATGA
CGGCGTGTCCTCATAGCCTC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MVAKTETFGGGLDDLRAFCAVVDLGTVTAAAASRGETKGSLSRRISRLEAALGAILIARHPRAVSPTAEGLAFYAKVQES
LALLDEAAETARDARTVPAGHLRVTTSVDFGIELMPGIVASFRRAYPQITVDMINTDARLDLAANRIDLALRLGDVEETG
YRAALILRLWVGLYAAPDYLARRPAPTSLAALPEHDLILSRERPGALGIMLSDGQGRTEQVALSPAVRASDFAAVLRLTL
AGTGIGHLPSAVAAGSVANGALVRVLAPWATAGGALRAVSLAGRELPARVRVFREHVRSEMMKRFAVEPDQAEGT

Sequences:

>Translated_315_residues
MVAKTETFGGGLDDLRAFCAVVDLGTVTAAAASRGETKGSLSRRISRLEAALGAILIARHPRAVSPTAEGLAFYAKVQES
LALLDEAAETARDARTVPAGHLRVTTSVDFGIELMPGIVASFRRAYPQITVDMINTDARLDLAANRIDLALRLGDVEETG
YRAALILRLWVGLYAAPDYLARRPAPTSLAALPEHDLILSRERPGALGIMLSDGQGRTEQVALSPAVRASDFAAVLRLTL
AGTGIGHLPSAVAAGSVANGALVRVLAPWATAGGALRAVSLAGRELPARVRVFREHVRSEMMKRFAVEPDQAEGT
>Mature_315_residues
MVAKTETFGGGLDDLRAFCAVVDLGTVTAAAASRGETKGSLSRRISRLEAALGAILIARHPRAVSPTAEGLAFYAKVQES
LALLDEAAETARDARTVPAGHLRVTTSVDFGIELMPGIVASFRRAYPQITVDMINTDARLDLAANRIDLALRLGDVEETG
YRAALILRLWVGLYAAPDYLARRPAPTSLAALPEHDLILSRERPGALGIMLSDGQGRTEQVALSPAVRASDFAAVLRLTL
AGTGIGHLPSAVAAGSVANGALVRVLAPWATAGGALRAVSLAGRELPARVRVFREHVRSEMMKRFAVEPDQAEGT

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=295, Percent_Identity=27.1186440677966, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789440, Length=296, Percent_Identity=29.3918918918919, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87081978, Length=303, Percent_Identity=27.3927392739274, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1789639, Length=281, Percent_Identity=23.1316725978648, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI145693193, Length=283, Percent_Identity=26.5017667844523, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787589, Length=258, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787128, Length=293, Percent_Identity=24.9146757679181, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33248; Mature: 33248

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAKTETFGGGLDDLRAFCAVVDLGTVTAAAASRGETKGSLSRRISRLEAALGAILIARH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PRAVSPTAEGLAFYAKVQESLALLDEAAETARDARTVPAGHLRVTTSVDFGIELMPGIVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHH
SFRRAYPQITVDMINTDARLDLAANRIDLALRLGDVEETGYRAALILRLWVGLYAAPDYL
HHHHHCCCEEEEEECCCCEEEEHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHH
ARRPAPTSLAALPEHDLILSRERPGALGIMLSDGQGRTEQVALSPAVRASDFAAVLRLTL
HCCCCCCCHHCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHH
AGTGIGHLPSAVAAGSVANGALVRVLAPWATAGGALRAVSLAGRELPARVRVFREHVRSE
HCCCCCCCHHHHHHCCCCCCCEEEEEECHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
MMKRFAVEPDQAEGT
HHHHHCCCCCCCCCC
>Mature Secondary Structure
MVAKTETFGGGLDDLRAFCAVVDLGTVTAAAASRGETKGSLSRRISRLEAALGAILIARH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PRAVSPTAEGLAFYAKVQESLALLDEAAETARDARTVPAGHLRVTTSVDFGIELMPGIVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHH
SFRRAYPQITVDMINTDARLDLAANRIDLALRLGDVEETGYRAALILRLWVGLYAAPDYL
HHHHHCCCEEEEEECCCCEEEEHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHH
ARRPAPTSLAALPEHDLILSRERPGALGIMLSDGQGRTEQVALSPAVRASDFAAVLRLTL
HCCCCCCCHHCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHH
AGTGIGHLPSAVAAGSVANGALVRVLAPWATAGGALRAVSLAGRELPARVRVFREHVRSE
HCCCCCCCHHHHHHCCCCCCCEEEEEECHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
MMKRFAVEPDQAEGT
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]