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The map label for this gene is serS [H]

Identifier: 170748700

GI number: 170748700

Start: 2412514

End: 2413917

Strand: Reverse

Name: serS [H]

Synonym: Mrad2831_2282

Alternate gene names: 170748700

Gene position: 2413917-2412514 (Counterclockwise)

Preceding gene: 170748701

Following gene: 170748699

Centisome position: 39.72

GC content: 71.23

Gene sequence:

>1404_bases
ATGCGGCAAAGCGGGGCCCGCGCGCTCGACGCCGCGCAGAAGACCCGAGCCGACTCGATGCACGACATCCGCGCCATCCG
GGAGAACCCGGACGCCTTCGACCGCGACCTCCAGCGCCGGGGCCTCGCGCCGCTCTCGGCCGAGCTGATCGCCCTCGATG
AGGCGCGGAAGTCGTCCGTCTCGGCCGCGCAGGCCAACCAGGAGCGGCGCAACGCCCTGGCCAAGGAGATCGGCGGCGCC
AAGAAGGCCAAGGACGAGGACCGCGCCGCCGCCCTGATGGCGGAGGTCGCGGCCCTGAAGGCGGCCGAGCCCGAGCTGAA
GGCCGCGCAGGACGCGGCCGACAGGACCCTGGCAGACCGCCTCGCCGCGATCCCGAACCGGCCGAAGCCCGACGTGCCGG
AGGGCGCGGACGAGCACGGCAACGTCCTCTACCGCAGCCACGCCGCGACCCGCGAGCGGCTGACCGAGGGCCGCGAGCAT
TTCGAGCTCGGCGAGGCCTCGGGCCTGATGGATTTCGAGGCGGCGGCCAAGCTGTCCGGCTCGCGCTTCGTGGTGCTCAA
AGGCCAGCTCGCCCGGCTGGAGCGGGCGCTCGGCCAGTTCATGCTCGACCTGCACACGCAGGAGCACGGCTACCTGGAGG
TGGCGCCGCCGGTGCTGGTGCGCGACGCCGCCATGTTCGGTACCGCGCAGCTGCCGAAGTTCGAGGACGACCAGTTCTCG
GTCTTCAAGGGCCTCGACTACGTCAGGTCGCTGCAGGGGCAGGCCGGCGCCGACACCGCCCCGGTCAGCGACGAGCATTT
CTGGCTCGTTCCCACAGCCGAGGTGCCGCTCACGAACCTCGTCCGCGAGGCGATCCTCCGCGAGGAGGAGCTGCCCCTGC
GGTTCACCGCGCTGACGCCCTGCTTCCGGGCCGAAGCGGGGGCGGCGGGGCGCGACACCCGCGGCATGCTGCGCCAGCAC
CAGTTCAGCAAGGTCGAGCTGGTCTCGATCACGACGCCGGAGGAATCCGCCAACGAGCACGAGCGGATGCTGACCAGCGC
CGAGGCCGTGCTGAAGAAGCTCGATCTGCCCTACCGGGTGATGACGCTCTGCACCGGCGACATGGGCTTCGCCAGCCAGA
AGACCTACGACATCGAGGTCTGGGTGCCGGGCCAGCGCACCCACCGCGAGATCTCGTCCTGCTCGGTCTGCGGCGACTTC
CAGGCGCGGCGGATGAACGCCCGCTACCGCGGCAAGGACGGCAAGCCGGCCTATGTCCACACCCTCAACGGCTCGGGCGT
GGCGGTCGGTCGCGCGCTCATCGCCGTGATGGAGAACTACCAGAACCCGGACGGGAGCATCACGGTCCCGTCGGTGCTCC
ACCCCTACATGGGCGGGCTCAACCGGATCGAAGGGGCCCGCTGA

Upstream 100 bases:

>100_bases
GACGGCACGTGGCTCTGGGCGATCGACCAGCTCAAGCTCGCGCCGCCGAAGAGCTGACGGTCGGCGCGGACGCTCCCGCG
CGCTTGTCCCACTGGACGCG

Downstream 100 bases:

>100_bases
TGCGCATCCTGGTCACCAACGACGACGGCATCCACGCGCCGGGCCTCGCGACCCTGGAGGAGATCGCCCGGGAGCTCTCG
GACGACGTCTGGGTCGTGGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MRQSGARALDAAQKTRADSMHDIRAIRENPDAFDRDLQRRGLAPLSAELIALDEARKSSVSAAQANQERRNALAKEIGGA
KKAKDEDRAAALMAEVAALKAAEPELKAAQDAADRTLADRLAAIPNRPKPDVPEGADEHGNVLYRSHAATRERLTEGREH
FELGEASGLMDFEAAAKLSGSRFVVLKGQLARLERALGQFMLDLHTQEHGYLEVAPPVLVRDAAMFGTAQLPKFEDDQFS
VFKGLDYVRSLQGQAGADTAPVSDEHFWLVPTAEVPLTNLVREAILREEELPLRFTALTPCFRAEAGAAGRDTRGMLRQH
QFSKVELVSITTPEESANEHERMLTSAEAVLKKLDLPYRVMTLCTGDMGFASQKTYDIEVWVPGQRTHREISSCSVCGDF
QARRMNARYRGKDGKPAYVHTLNGSGVAVGRALIAVMENYQNPDGSITVPSVLHPYMGGLNRIEGAR

Sequences:

>Translated_467_residues
MRQSGARALDAAQKTRADSMHDIRAIRENPDAFDRDLQRRGLAPLSAELIALDEARKSSVSAAQANQERRNALAKEIGGA
KKAKDEDRAAALMAEVAALKAAEPELKAAQDAADRTLADRLAAIPNRPKPDVPEGADEHGNVLYRSHAATRERLTEGREH
FELGEASGLMDFEAAAKLSGSRFVVLKGQLARLERALGQFMLDLHTQEHGYLEVAPPVLVRDAAMFGTAQLPKFEDDQFS
VFKGLDYVRSLQGQAGADTAPVSDEHFWLVPTAEVPLTNLVREAILREEELPLRFTALTPCFRAEAGAAGRDTRGMLRQH
QFSKVELVSITTPEESANEHERMLTSAEAVLKKLDLPYRVMTLCTGDMGFASQKTYDIEVWVPGQRTHREISSCSVCGDF
QARRMNARYRGKDGKPAYVHTLNGSGVAVGRALIAVMENYQNPDGSITVPSVLHPYMGGLNRIEGAR
>Mature_467_residues
MRQSGARALDAAQKTRADSMHDIRAIRENPDAFDRDLQRRGLAPLSAELIALDEARKSSVSAAQANQERRNALAKEIGGA
KKAKDEDRAAALMAEVAALKAAEPELKAAQDAADRTLADRLAAIPNRPKPDVPEGADEHGNVLYRSHAATRERLTEGREH
FELGEASGLMDFEAAAKLSGSRFVVLKGQLARLERALGQFMLDLHTQEHGYLEVAPPVLVRDAAMFGTAQLPKFEDDQFS
VFKGLDYVRSLQGQAGADTAPVSDEHFWLVPTAEVPLTNLVREAILREEELPLRFTALTPCFRAEAGAAGRDTRGMLRQH
QFSKVELVSITTPEESANEHERMLTSAEAVLKKLDLPYRVMTLCTGDMGFASQKTYDIEVWVPGQRTHREISSCSVCGDF
QARRMNARYRGKDGKPAYVHTLNGSGVAVGRALIAVMENYQNPDGSITVPSVLHPYMGGLNRIEGAR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=345, Percent_Identity=34.4927536231884, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI8923421, Length=337, Percent_Identity=30.2670623145401, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI225579074, Length=337, Percent_Identity=30.2670623145401, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1787120, Length=445, Percent_Identity=51.9101123595506, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17539260, Length=463, Percent_Identity=31.7494600431965, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=326, Percent_Identity=28.8343558282209, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=408, Percent_Identity=31.1274509803922, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=387, Percent_Identity=31.0077519379845, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24581334, Length=362, Percent_Identity=32.3204419889503, Blast_Score=178, Evalue=8e-45,
Organism=Drosophila melanogaster, GI17737985, Length=366, Percent_Identity=32.7868852459016, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 51207; Mature: 51207

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSGARALDAAQKTRADSMHDIRAIRENPDAFDRDLQRRGLAPLSAELIALDEARKSSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
SAAQANQERRNALAKEIGGAKKAKDEDRAAALMAEVAALKAAEPELKAAQDAADRTLADR
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LAAIPNRPKPDVPEGADEHGNVLYRSHAATRERLTEGREHFELGEASGLMDFEAAAKLSG
HHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHCCC
SRFVVLKGQLARLERALGQFMLDLHTQEHGYLEVAPPVLVRDAAMFGTAQLPKFEDDQFS
CEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCHHH
VFKGLDYVRSLQGQAGADTAPVSDEHFWLVPTAEVPLTNLVREAILREEELPLRFTALTP
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCH
CFRAEAGAAGRDTRGMLRQHQFSKVELVSITTPEESANEHERMLTSAEAVLKKLDLPYRV
HHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEE
MTLCTGDMGFASQKTYDIEVWVPGQRTHREISSCSVCGDFQARRMNARYRGKDGKPAYVH
HHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCEEE
TLNGSGVAVGRALIAVMENYQNPDGSITVPSVLHPYMGGLNRIEGAR
EECCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHCCHHHCCCCC
>Mature Secondary Structure
MRQSGARALDAAQKTRADSMHDIRAIRENPDAFDRDLQRRGLAPLSAELIALDEARKSSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
SAAQANQERRNALAKEIGGAKKAKDEDRAAALMAEVAALKAAEPELKAAQDAADRTLADR
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LAAIPNRPKPDVPEGADEHGNVLYRSHAATRERLTEGREHFELGEASGLMDFEAAAKLSG
HHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHCCC
SRFVVLKGQLARLERALGQFMLDLHTQEHGYLEVAPPVLVRDAAMFGTAQLPKFEDDQFS
CEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCHHH
VFKGLDYVRSLQGQAGADTAPVSDEHFWLVPTAEVPLTNLVREAILREEELPLRFTALTP
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCH
CFRAEAGAAGRDTRGMLRQHQFSKVELVSITTPEESANEHERMLTSAEAVLKKLDLPYRV
HHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEE
MTLCTGDMGFASQKTYDIEVWVPGQRTHREISSCSVCGDFQARRMNARYRGKDGKPAYVH
HHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCEEE
TLNGSGVAVGRALIAVMENYQNPDGSITVPSVLHPYMGGLNRIEGAR
EECCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA