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The map label for this gene is nqo3 [H]

Identifier: 170748471

GI number: 170748471

Start: 2183102

End: 2185183

Strand: Reverse

Name: nqo3 [H]

Synonym: Mrad2831_2053

Alternate gene names: 170748471

Gene position: 2185183-2183102 (Counterclockwise)

Preceding gene: 170748472

Following gene: 170748470

Centisome position: 35.95

GC content: 71.28

Gene sequence:

>2082_bases
ATGACAAAAATCCTCGTCGACGGCACCGAGGTCGACGTCCCCGCCGATTACACGCTGCTCCAGGCCTGCGAGGCCGCGGG
GGCCGAGATCCCGCGCTTCTGCTTCCACGAGCGCCTGTCGATCGCCGGCAATTGCCGCATGTGCCTCGTCGAGCTGAAGG
GCGCGCCGAAGCCGGTGGCCTCCTGCGCCTACGCGGTGAAGGATTGCCGCCCCGGCCCGAACGGCGAGCCGCCGGAGGTG
CTGACCCGCTCGCAGGGCACCAAGAAAGCGCGGGAAGGGGTGATGGAGTTCCTCCTCATCAACCACCCCCTCGACTGCCC
GATCTGCGACCAGGGCGGCCACTGCGACCTGCAGGACCAGGCCATGGCCTACGGGGTCGATTCGACCCGCTACACGGAGA
ACAAGCGCGCGGTCGAGGAGAAGCATATCGGGCCGCTGGTGCGGACCGCGATGAACCGCTGCATACACTGCACCCGCTGC
GTGCGCTTCCTCGCCGAGGTGGCGGGCGTGCCCGACCTCGGCGCCATCGGTCGCGGCGAGGACATGGAGATCACCAGCTA
CCTCGAGCAGTCGATGGCCTCGGAGCTTCAGGGCAACGTCGCCGACCTCTGCCCGGTCGGCGCCCTCGTGCACCGGCCGC
AGAGCTACAACGTCCGCCCCTGGGAGCTGAACAAGACCGAGTCGGTCGACGTGATGGACGCGGTCGGCTCGTCGATCCGC
ATCGACACCCGCGGCCGCGAGGTCATGCAGATCGAGCCGCGGATCAGCGAGGAGATCAACGAGGAGTGGATCTCCGACAA
GACGCGCTACCACATCGATGGGCTGCGGATGCAGCGCCTCGACCGGCCCTACCTGCGCGAGAACGGTCGCCTGCGTCCCG
CCTCCTGGGGTGAGGTTTTTCAGGCGATCGCCGCCAAGGTGAAGGGCGCGGATCCGAAGCGCATCGGCGCGATCGTCGGC
GATCTTTCGGGCGTCGAGGAGATCTACGCGCTCCGCGAGCTGATGAAGGGTCTCGGCTCGCCGAACCTCGACTGCCGCCA
GACCGATGCCGGCCTCGACCCGGCGCTCGGCCGCGCCTCCTACATCTTCAACCCGACGATCGCGGGCCTCGAGGCCGCGG
ACGCGATCCTGATCGTCGGCGCCAACCCGCGCACCGAGGCCTCGCTGCTGAACGTGCGGATCCGCAAGCGCTGGCGCATG
GCGCCGCTGGCGGTGGGCGTGATCGGCGAGCCGGTCGACCTGACCTATCCGAGCCACTACATCGGCGCCGGCCCCGATTC
GCTGGCGGCGCTCGCCCGCGGCGAGCACAGCTTCCTCGACGTGCTCAAGGAGGCCAAGGCGCCGCTCGTGATCGTCGGCG
CGAGCGCCGCGCCGGACGTCCTGGCCGCTGCAGCCTCCCTCGCGAAGGAGATCGGCGCGGTCTCGGCCGAGTGGAACGGC
TTCGGCGTGCTGCACACGGCCGCTGCCCGGGTCGGGGCGCTCGATCTCGGCTTCGTGCCGGGGGAGGGCGGATTGACCTT
CGCGCAGATGCTGGAGCCCGGCGCCCTCGACGTCCTGTTCAACCTCGGCGCCGACGAGCGTGACGTCGCCCCGGGCGCTT
TCGTGGTCTACCAGGGCAGCCACGGAGATCGCGGGGCCTCCCGCGCCGACGTGATCCTGCCGGGGGCCGCCTATAGCGAG
AAGTCGGCGACCTGGGTGAACACGGAAGGCCGGGTCCAGATGGGCAACCGCGCCGCCTTCCCGCCGGGCGACGCCCGCGA
GGATTGGGCGATCCTGCGCGCCCTCTCGGACGTGCTGGGCAAGCGCCTGCCGTTCGACTCGCTCACCGCCCTCCGCCGGG
CGCTCTACGCCGCCCACCCGCATCTGGCGGCGATCGGGGCCGTGGCGCCCGGCACCGTCGCGGAAGCGGTCGACCGGCTC
GCCGGTCTCGGCGGCTCCGCGACCGGACCGGCCTTCGCGTCGCCGGTGACCGACTTCTATCTCACCAACCCGATCGCCCG
CGCCTCGCGCATCCTCGCGGAGTGCTCGCGCCTCGCCCGGGAGCGCGCCGCCGAGGCGCGGCCCCTCGCGGCGGCCGAGT
AG

Upstream 100 bases:

>100_bases
CTGGCTGGCGTCCACCGGCGGATCGACAGGGTCGAGCTTCGCATCGAGCGGATCGAGCGACGCCTCGATCTCGCCGACGC
CCCGCACTGAGATTGCACCG

Downstream 100 bases:

>100_bases
GAGCTCAAGACCGATGACGCCGCTCGAAATCCTCGGGACCGTGCTCCTGATCGTGCTGAAGAGCTTCGTGCTCCTCTCGG
CGCTCCTCGTCTTCATCGCC

Product: NADH dehydrogenase subunit G

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 3; NDH-1, chain 3 [H]

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MTKILVDGTEVDVPADYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLVELKGAPKPVASCAYAVKDCRPGPNGEPPEV
LTRSQGTKKAREGVMEFLLINHPLDCPICDQGGHCDLQDQAMAYGVDSTRYTENKRAVEEKHIGPLVRTAMNRCIHCTRC
VRFLAEVAGVPDLGAIGRGEDMEITSYLEQSMASELQGNVADLCPVGALVHRPQSYNVRPWELNKTESVDVMDAVGSSIR
IDTRGREVMQIEPRISEEINEEWISDKTRYHIDGLRMQRLDRPYLRENGRLRPASWGEVFQAIAAKVKGADPKRIGAIVG
DLSGVEEIYALRELMKGLGSPNLDCRQTDAGLDPALGRASYIFNPTIAGLEAADAILIVGANPRTEASLLNVRIRKRWRM
APLAVGVIGEPVDLTYPSHYIGAGPDSLAALARGEHSFLDVLKEAKAPLVIVGASAAPDVLAAAASLAKEIGAVSAEWNG
FGVLHTAAARVGALDLGFVPGEGGLTFAQMLEPGALDVLFNLGADERDVAPGAFVVYQGSHGDRGASRADVILPGAAYSE
KSATWVNTEGRVQMGNRAAFPPGDAREDWAILRALSDVLGKRLPFDSLTALRRALYAAHPHLAAIGAVAPGTVAEAVDRL
AGLGGSATGPAFASPVTDFYLTNPIARASRILAECSRLARERAAEARPLAAAE

Sequences:

>Translated_693_residues
MTKILVDGTEVDVPADYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLVELKGAPKPVASCAYAVKDCRPGPNGEPPEV
LTRSQGTKKAREGVMEFLLINHPLDCPICDQGGHCDLQDQAMAYGVDSTRYTENKRAVEEKHIGPLVRTAMNRCIHCTRC
VRFLAEVAGVPDLGAIGRGEDMEITSYLEQSMASELQGNVADLCPVGALVHRPQSYNVRPWELNKTESVDVMDAVGSSIR
IDTRGREVMQIEPRISEEINEEWISDKTRYHIDGLRMQRLDRPYLRENGRLRPASWGEVFQAIAAKVKGADPKRIGAIVG
DLSGVEEIYALRELMKGLGSPNLDCRQTDAGLDPALGRASYIFNPTIAGLEAADAILIVGANPRTEASLLNVRIRKRWRM
APLAVGVIGEPVDLTYPSHYIGAGPDSLAALARGEHSFLDVLKEAKAPLVIVGASAAPDVLAAAASLAKEIGAVSAEWNG
FGVLHTAAARVGALDLGFVPGEGGLTFAQMLEPGALDVLFNLGADERDVAPGAFVVYQGSHGDRGASRADVILPGAAYSE
KSATWVNTEGRVQMGNRAAFPPGDAREDWAILRALSDVLGKRLPFDSLTALRRALYAAHPHLAAIGAVAPGTVAEAVDRL
AGLGGSATGPAFASPVTDFYLTNPIARASRILAECSRLARERAAEARPLAAAE
>Mature_692_residues
TKILVDGTEVDVPADYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLVELKGAPKPVASCAYAVKDCRPGPNGEPPEVL
TRSQGTKKAREGVMEFLLINHPLDCPICDQGGHCDLQDQAMAYGVDSTRYTENKRAVEEKHIGPLVRTAMNRCIHCTRCV
RFLAEVAGVPDLGAIGRGEDMEITSYLEQSMASELQGNVADLCPVGALVHRPQSYNVRPWELNKTESVDVMDAVGSSIRI
DTRGREVMQIEPRISEEINEEWISDKTRYHIDGLRMQRLDRPYLRENGRLRPASWGEVFQAIAAKVKGADPKRIGAIVGD
LSGVEEIYALRELMKGLGSPNLDCRQTDAGLDPALGRASYIFNPTIAGLEAADAILIVGANPRTEASLLNVRIRKRWRMA
PLAVGVIGEPVDLTYPSHYIGAGPDSLAALARGEHSFLDVLKEAKAPLVIVGASAAPDVLAAAASLAKEIGAVSAEWNGF
GVLHTAAARVGALDLGFVPGEGGLTFAQMLEPGALDVLFNLGADERDVAPGAFVVYQGSHGDRGASRADVILPGAAYSEK
SATWVNTEGRVQMGNRAAFPPGDAREDWAILRALSDVLGKRLPFDSLTALRRALYAAHPHLAAIGAVAPGTVAEAVDRLA
GLGGSATGPAFASPVTDFYLTNPIARASRILAECSRLARERAAEARPLAAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=706, Percent_Identity=48.8668555240793, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI145693161, Length=704, Percent_Identity=26.2784090909091, Blast_Score=197, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17565758, Length=699, Percent_Identity=46.6380543633763, Blast_Score=601, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI32566231, Length=587, Percent_Identity=48.381601362862, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI193209088, Length=258, Percent_Identity=56.5891472868217, Blast_Score=307, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24640559, Length=690, Percent_Identity=48.8405797101449, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24640557, Length=690, Percent_Identity=48.8405797101449, Blast_Score=595, Evalue=1e-170,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74071; Mature: 73940

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKILVDGTEVDVPADYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLVELKGAPKPVA
CCEEEECCCEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHH
SCAYAVKDCRPGPNGEPPEVLTRSQGTKKAREGVMEFLLINHPLDCPICDQGGHCDLQDQ
HHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
AMAYGVDSTRYTENKRAVEEKHIGPLVRTAMNRCIHCTRCVRFLAEVAGVPDLGAIGRGE
HHHCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DMEITSYLEQSMASELQGNVADLCPVGALVHRPQSYNVRPWELNKTESVDVMDAVGSSIR
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCEE
IDTRGREVMQIEPRISEEINEEWISDKTRYHIDGLRMQRLDRPYLRENGRLRPASWGEVF
EECCCCEEEEECCHHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHHCCCCCCCCCHHHHH
QAIAAKVKGADPKRIGAIVGDLSGVEEIYALRELMKGLGSPNLDCRQTDAGLDPALGRAS
HHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE
YIFNPTIAGLEAADAILIVGANPRTEASLLNVRIRKRWRMAPLAVGVIGEPVDLTYPSHY
EEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC
IGAGPDSLAALARGEHSFLDVLKEAKAPLVIVGASAAPDVLAAAASLAKEIGAVSAEWNG
CCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
FGVLHTAAARVGALDLGFVPGEGGLTFAQMLEPGALDVLFNLGADERDVAPGAFVVYQGS
CCHHHHHHHHHCCEEEEEECCCCCCCHHHHHCCCCEEHHEECCCCCCCCCCCEEEEEECC
HGDRGASRADVILPGAAYSEKSATWVNTEGRVQMGNRAAFPPGDAREDWAILRALSDVLG
CCCCCCCCCCEEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHH
KRLPFDSLTALRRALYAAHPHLAAIGAVAPGTVAEAVDRLAGLGGSATGPAFASPVTDFY
CCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHCCHHHHH
LTNPIARASRILAECSRLARERAAEARPLAAAE
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TKILVDGTEVDVPADYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLVELKGAPKPVA
CEEEECCCEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHH
SCAYAVKDCRPGPNGEPPEVLTRSQGTKKAREGVMEFLLINHPLDCPICDQGGHCDLQDQ
HHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
AMAYGVDSTRYTENKRAVEEKHIGPLVRTAMNRCIHCTRCVRFLAEVAGVPDLGAIGRGE
HHHCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DMEITSYLEQSMASELQGNVADLCPVGALVHRPQSYNVRPWELNKTESVDVMDAVGSSIR
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCEE
IDTRGREVMQIEPRISEEINEEWISDKTRYHIDGLRMQRLDRPYLRENGRLRPASWGEVF
EECCCCEEEEECCHHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHHCCCCCCCCCHHHHH
QAIAAKVKGADPKRIGAIVGDLSGVEEIYALRELMKGLGSPNLDCRQTDAGLDPALGRAS
HHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE
YIFNPTIAGLEAADAILIVGANPRTEASLLNVRIRKRWRMAPLAVGVIGEPVDLTYPSHY
EEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC
IGAGPDSLAALARGEHSFLDVLKEAKAPLVIVGASAAPDVLAAAASLAKEIGAVSAEWNG
CCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
FGVLHTAAARVGALDLGFVPGEGGLTFAQMLEPGALDVLFNLGADERDVAPGAFVVYQGS
CCHHHHHHHHHCCEEEEEECCCCCCCHHHHHCCCCEEHHEECCCCCCCCCCCEEEEEECC
HGDRGASRADVILPGAAYSEKSATWVNTEGRVQMGNRAAFPPGDAREDWAILRALSDVLG
CCCCCCCCCCEEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHH
KRLPFDSLTALRRALYAAHPHLAAIGAVAPGTVAEAVDRLAGLGGSATGPAFASPVTDFY
CCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHCCHHHHH
LTNPIARASRILAECSRLARERAAEARPLAAAE
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1605643; 8422400 [H]