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The map label for this gene is nuoH1 [H]

Identifier: 170748470

GI number: 170748470

Start: 2182066

End: 2183088

Strand: Reverse

Name: nuoH1 [H]

Synonym: Mrad2831_2052

Alternate gene names: 170748470

Gene position: 2183088-2182066 (Counterclockwise)

Preceding gene: 170748471

Following gene: 170748469

Centisome position: 35.92

GC content: 65.4

Gene sequence:

>1023_bases
ATGACGCCGCTCGAAATCCTCGGGACCGTGCTCCTGATCGTGCTGAAGAGCTTCGTGCTCCTCTCGGCGCTCCTCGTCTT
CATCGCCTACGCGCTGCTCGCCGACCGGAAGATCTGGGCGGCGGTGCAGCTCCGGCGCGGCCCGAACGTGGTCGGGCCGT
TCGGCCTGTTCCAGTCCTTCGCCGACCTGATCAAGTTCGTGATCAAGGAGCCGGTGATCCCGGCGGGCGCCAACAAGGCG
ATCTACCTGCTGGCGCCGCTGGTCTTCGCGATGCTCGCCCTGTCGAGCTGGGCGGTGATCCCGCTCGCCGACGGCTGGGC
GATCGCCGACATCAACGTCGGCATCACCTACATCTTCGCGATCTCGTCGCTCGGCGTGTACGGCGTCATCATGGGCGGCT
GGGCGTCGAACTCGAAATACGCGTTCCTCGGCGCGCTCCGCTCGGCGGCGCAGATGATCTCGTACGAGGTGTCGCTCGGC
TTCGTGATCATCTGCGTGCTGCTCTGCGCCGGCTCGCTCAACCTCTCGCGCATCGTCATGGCGCAGGACACCAGTCTCGG
GATCTTCGGCTGGTACTGGCTGTGGCTGTTCCCGATGTTCGTGGTGTTCTTTGTCTCGGCGCTCGCCGAGACCAACCGCC
CGCCCTTCGACCTGCCGGAGGCCGAGTCGGAGCTCGTGGCCGGCTACATGGTCGAGTATTCCTCGACCCCGTACCTGCTG
TTCATGCTCGGCGAGTACGTCGCCATCATGAGCATGTGCGCCCTCGGGACCATCCTGTTCATGGGCGGCTGGCTGTCCCC
GATCCCGTTCGCGCCCTTCACCTGGGTGCCGGGCGTGATCTGGTTCACCCTGAAGGCCAGCTTCCTGTTCTTCCTGTTCG
CGATGGTGAAGTCCATCGTGCCCCGCTACCGCTACGATCAGCTCATGCGCCTCGGCTGGAAGGTCTTCCTGCCGATCTCC
CTGATCTCGGTCGTCGTCGTCGCCTTCGTGCTCAAGCTGACCGGCCTCGCGCCGGGCGCCTGA

Upstream 100 bases:

>100_bases
GCCCGCGCCTCGCGCATCCTCGCGGAGTGCTCGCGCCTCGCCCGGGAGCGCGCCGCCGAGGCGCGGCCCCTCGCGGCGGC
CGAGTAGGAGCTCAAGACCG

Downstream 100 bases:

>100_bases
GCCCACCCTTCGCATCGGAGATCCGGGCATGAAGCTCGATCAGGTCGCCAAGAGCCTTCTCCTGAAGGAGTTCGTGTCGG
GGATGATCCTCGGCATGCGC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 1; NDH-1 subunit H 1 [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTPLEILGTVLLIVLKSFVLLSALLVFIAYALLADRKIWAAVQLRRGPNVVGPFGLFQSFADLIKFVIKEPVIPAGANKA
IYLLAPLVFAMLALSSWAVIPLADGWAIADINVGITYIFAISSLGVYGVIMGGWASNSKYAFLGALRSAAQMISYEVSLG
FVIICVLLCAGSLNLSRIVMAQDTSLGIFGWYWLWLFPMFVVFFVSALAETNRPPFDLPEAESELVAGYMVEYSSTPYLL
FMLGEYVAIMSMCALGTILFMGGWLSPIPFAPFTWVPGVIWFTLKASFLFFLFAMVKSIVPRYRYDQLMRLGWKVFLPIS
LISVVVVAFVLKLTGLAPGA

Sequences:

>Translated_340_residues
MTPLEILGTVLLIVLKSFVLLSALLVFIAYALLADRKIWAAVQLRRGPNVVGPFGLFQSFADLIKFVIKEPVIPAGANKA
IYLLAPLVFAMLALSSWAVIPLADGWAIADINVGITYIFAISSLGVYGVIMGGWASNSKYAFLGALRSAAQMISYEVSLG
FVIICVLLCAGSLNLSRIVMAQDTSLGIFGWYWLWLFPMFVVFFVSALAETNRPPFDLPEAESELVAGYMVEYSSTPYLL
FMLGEYVAIMSMCALGTILFMGGWLSPIPFAPFTWVPGVIWFTLKASFLFFLFAMVKSIVPRYRYDQLMRLGWKVFLPIS
LISVVVVAFVLKLTGLAPGA
>Mature_339_residues
TPLEILGTVLLIVLKSFVLLSALLVFIAYALLADRKIWAAVQLRRGPNVVGPFGLFQSFADLIKFVIKEPVIPAGANKAI
YLLAPLVFAMLALSSWAVIPLADGWAIADINVGITYIFAISSLGVYGVIMGGWASNSKYAFLGALRSAAQMISYEVSLGF
VIICVLLCAGSLNLSRIVMAQDTSLGIFGWYWLWLFPMFVVFFVSALAETNRPPFDLPEAESELVAGYMVEYSSTPYLLF
MLGEYVAIMSMCALGTILFMGGWLSPIPFAPFTWVPGVIWFTLKASFLFFLFAMVKSIVPRYRYDQLMRLGWKVFLPISL
ISVVVVAFVLKLTGLAPGA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=294, Percent_Identity=42.5170068027211, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI1788618, Length=323, Percent_Identity=39.6284829721362, Blast_Score=242, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 37330; Mature: 37199

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLEILGTVLLIVLKSFVLLSALLVFIAYALLADRKIWAAVQLRRGPNVVGPFGLFQSF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHH
ADLIKFVIKEPVIPAGANKAIYLLAPLVFAMLALSSWAVIPLADGWAIADINVGITYIFA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCHHHHHHH
ISSLGVYGVIMGGWASNSKYAFLGALRSAAQMISYEVSLGFVIICVLLCAGSLNLSRIVM
HHHCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEE
AQDTSLGIFGWYWLWLFPMFVVFFVSALAETNRPPFDLPEAESELVAGYMVEYSSTPYLL
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHEECCCCCHH
FMLGEYVAIMSMCALGTILFMGGWLSPIPFAPFTWVPGVIWFTLKASFLFFLFAMVKSIV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PRYRYDQLMRLGWKVFLPISLISVVVVAFVLKLTGLAPGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TPLEILGTVLLIVLKSFVLLSALLVFIAYALLADRKIWAAVQLRRGPNVVGPFGLFQSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHH
ADLIKFVIKEPVIPAGANKAIYLLAPLVFAMLALSSWAVIPLADGWAIADINVGITYIFA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCHHHHHHH
ISSLGVYGVIMGGWASNSKYAFLGALRSAAQMISYEVSLGFVIICVLLCAGSLNLSRIVM
HHHCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEE
AQDTSLGIFGWYWLWLFPMFVVFFVSALAETNRPPFDLPEAESELVAGYMVEYSSTPYLL
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHEECCCCCHH
FMLGEYVAIMSMCALGTILFMGGWLSPIPFAPFTWVPGVIWFTLKASFLFFLFAMVKSIV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PRYRYDQLMRLGWKVFLPISLISVVVVAFVLKLTGLAPGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA