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The map label for this gene is nuoN [H]

Identifier: 170747115

GI number: 170747115

Start: 725455

End: 727209

Strand: Reverse

Name: nuoN [H]

Synonym: Mrad2831_0681

Alternate gene names: 170747115

Gene position: 727209-725455 (Counterclockwise)

Preceding gene: 170747116

Following gene: 170747112

Centisome position: 11.96

GC content: 72.14

Gene sequence:

>1755_bases
GTGACCGCCTTCCCGGCCGCCCTCCTGCCCCTGCCCGTCGCCATACCGCTCGTGATCTGCGCGGCGATGCTGGCCACCGC
GCACCTCCTGCCCGGCCGCCTCCCCGACATCCTGGCGACGCTGTCGGCTCTCACCGTCGCGGCGCTCTGCGGTGTCATCG
CCACCCACGCCGCCGGCGAGCCTCTGGTCTACTGGTTCGGCGGCTGGGCGCCGCGCGACGGCGTCCATCTCGGCATCGGC
TTCTCCGTGGACGAGGCCAGCGCTTGGGTCGCGGCCTTCATCGGGCTGCTCTACGCGCTGACCTTCGTGTTCGCCTGGGG
TTTCTTCGACCGCACCCACGGCCACTTCCACATCCTGATGCTGCTGTTCCTGGCCGCCATGGTCGGGTTCTGCTTCACCC
GCGACATGTTCAATCTGTTCGTGTGGTTCGAGGTGATGAGCGTCGCCGCCTTCGCGCTCACGGCCTACCATCTGGCGGAA
TCGTCGCTGGCGGGCGCCATCAACTTCACGGTGGTCAACAGCCTCGCGGGCTTCCTGATGCTCGGCGGCATCGGGCTGAT
CTACGCCCAGACCGGCACGCTCGACTTCGAGGGCATCGCGGCCGCGGTGGCGCGGGGCGGCCGGGATCCGGTGGTGGCCG
GGGCGTTCTGCCTCGTGGCGACCGCCCTGATGATCAAGGGCGCGATCGTGCCGTTCCAGTTCTGGCTCGCCGACGCCCAC
GCGGTGGCGCCGAGCCCGGTCTCGGTGATCTTCTCCGGATCGATGGTCTCGCTCGGGCTGTTCGGCCTCGCGAAGGTGAG
CGCCGTCGTGTTCGGCGGCTCCGATCAGGTCCAGCAAGCCCTGCCGGCCCTCCTCATCGGCCTCGGCAGCTTCACCGCCC
TCCTGGGTGGCTGGATGGCGCTGCTGCAGCGGCACCTCAAGCGCATGCTCGCCTTCTCGACGATCTCGCATGCCGGGATC
ATGCTCACCGGTCTCGGCGCCCTCACGGTGGACGGGACCGGCGGGATGCTCGTCTACGTGGTGGGGCACGGGCTGGTGAA
GGGGGCCCTGTTCATGATCGCCGGCATCCTGCTCGCCACCCAGGCCAGCATCGACGAGATCGCCCTGCGCGGCCTCGGGC
GGGGGATCTGGCCCGCCGGGGTCGCCATGGCTCTGGCCGGGCTGCTGCTCTGCGGCCTGCCCCTCGGGGTGCTCGACCAG
GGCACGCGCCTCGTTCAGGGTGCGCTGGCGCAGCAGGGCCACGGGATCGCCCTGGCGGCCGGCGCCATCGGTGCGGCGCT
GACCGGGGCCGCGGTGCTGCGGGCCGCGGGCCGGATCTTCCTCGGGCTCGGGCCCGATCCCGGTGACGAGGCCGGGGCCC
CGAGCGAGGACGAGCGTGAGAAGGCCAACCGGCCGCTCTGGCTGATGCTGGCGCCGTGCTGCCTCCTCCTCGCCCTCGAT
ATCGGTCTGCCGGCTGGCCTTATCGAGCACGCCCTCCCGCGGGCGGCGTCGGCCTTCATGCATCGGCCGGCCGTGGTCGC
GCTGGCGGAGGGGCCGGTCTGGCTTCCCTGGGCCTCGCTCGCCGCCGCCCTCGCCGGCGCGGGCTACGGCCTGTTCCGGA
GGCACCTGCCCGCATCGGTGGTCCGGCCAGTCAGCGCCTCGCAATCGGCGCCGACCCGCGCGCTGGAAGTGCTCCACAGC
GGCTTGATCGGCGACTACGCGGCGTGGCTCGCGGTCGGCGTGGCGGTGATCGCGGCCGTGCTGGCCATGGCGTGA

Upstream 100 bases:

>100_bases
GCAGCCTGGACCCGGAGAAGCTCCGCCCGATGCGCGCGGGCGGCAAGTCCGGGCGCGACCCGGAATCGAGCCGGGTGCGC
GGGGCGGAGCGAAGCGCGCC

Downstream 100 bases:

>100_bases
GGGCGACCCGCGACAGGGCTTCGCGGGCTCGTGCCGGCGCGGGTCGTCGAACGGAGGTCCGGCCGCGCCAGACCTTCCAG
GAGGAGGATTTGGTTATCGA

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MTAFPAALLPLPVAIPLVICAAMLATAHLLPGRLPDILATLSALTVAALCGVIATHAAGEPLVYWFGGWAPRDGVHLGIG
FSVDEASAWVAAFIGLLYALTFVFAWGFFDRTHGHFHILMLLFLAAMVGFCFTRDMFNLFVWFEVMSVAAFALTAYHLAE
SSLAGAINFTVVNSLAGFLMLGGIGLIYAQTGTLDFEGIAAAVARGGRDPVVAGAFCLVATALMIKGAIVPFQFWLADAH
AVAPSPVSVIFSGSMVSLGLFGLAKVSAVVFGGSDQVQQALPALLIGLGSFTALLGGWMALLQRHLKRMLAFSTISHAGI
MLTGLGALTVDGTGGMLVYVVGHGLVKGALFMIAGILLATQASIDEIALRGLGRGIWPAGVAMALAGLLLCGLPLGVLDQ
GTRLVQGALAQQGHGIALAAGAIGAALTGAAVLRAAGRIFLGLGPDPGDEAGAPSEDEREKANRPLWLMLAPCCLLLALD
IGLPAGLIEHALPRAASAFMHRPAVVALAEGPVWLPWASLAAALAGAGYGLFRRHLPASVVRPVSASQSAPTRALEVLHS
GLIGDYAAWLAVGVAVIAAVLAMA

Sequences:

>Translated_584_residues
MTAFPAALLPLPVAIPLVICAAMLATAHLLPGRLPDILATLSALTVAALCGVIATHAAGEPLVYWFGGWAPRDGVHLGIG
FSVDEASAWVAAFIGLLYALTFVFAWGFFDRTHGHFHILMLLFLAAMVGFCFTRDMFNLFVWFEVMSVAAFALTAYHLAE
SSLAGAINFTVVNSLAGFLMLGGIGLIYAQTGTLDFEGIAAAVARGGRDPVVAGAFCLVATALMIKGAIVPFQFWLADAH
AVAPSPVSVIFSGSMVSLGLFGLAKVSAVVFGGSDQVQQALPALLIGLGSFTALLGGWMALLQRHLKRMLAFSTISHAGI
MLTGLGALTVDGTGGMLVYVVGHGLVKGALFMIAGILLATQASIDEIALRGLGRGIWPAGVAMALAGLLLCGLPLGVLDQ
GTRLVQGALAQQGHGIALAAGAIGAALTGAAVLRAAGRIFLGLGPDPGDEAGAPSEDEREKANRPLWLMLAPCCLLLALD
IGLPAGLIEHALPRAASAFMHRPAVVALAEGPVWLPWASLAAALAGAGYGLFRRHLPASVVRPVSASQSAPTRALEVLHS
GLIGDYAAWLAVGVAVIAAVLAMA
>Mature_583_residues
TAFPAALLPLPVAIPLVICAAMLATAHLLPGRLPDILATLSALTVAALCGVIATHAAGEPLVYWFGGWAPRDGVHLGIGF
SVDEASAWVAAFIGLLYALTFVFAWGFFDRTHGHFHILMLLFLAAMVGFCFTRDMFNLFVWFEVMSVAAFALTAYHLAES
SLAGAINFTVVNSLAGFLMLGGIGLIYAQTGTLDFEGIAAAVARGGRDPVVAGAFCLVATALMIKGAIVPFQFWLADAHA
VAPSPVSVIFSGSMVSLGLFGLAKVSAVVFGGSDQVQQALPALLIGLGSFTALLGGWMALLQRHLKRMLAFSTISHAGIM
LTGLGALTVDGTGGMLVYVVGHGLVKGALFMIAGILLATQASIDEIALRGLGRGIWPAGVAMALAGLLLCGLPLGVLDQG
TRLVQGALAQQGHGIALAAGAIGAALTGAAVLRAAGRIFLGLGPDPGDEAGAPSEDEREKANRPLWLMLAPCCLLLALDI
GLPAGLIEHALPRAASAFMHRPAVVALAEGPVWLPWASLAAALAGAGYGLFRRHLPASVVRPVSASQSAPTRALEVLHSG
LIGDYAAWLAVGVAVIAAVLAMA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=379, Percent_Identity=24.2744063324538, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1788613, Length=320, Percent_Identity=27.1875, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1788827, Length=444, Percent_Identity=27.4774774774775, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693160, Length=379, Percent_Identity=28.7598944591029, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788829, Length=335, Percent_Identity=27.1641791044776, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788614, Length=343, Percent_Identity=26.8221574344023, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788831, Length=349, Percent_Identity=24.3553008595989, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 59930; Mature: 59798

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFPAALLPLPVAIPLVICAAMLATAHLLPGRLPDILATLSALTVAALCGVIATHAAGE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PLVYWFGGWAPRDGVHLGIGFSVDEASAWVAAFIGLLYALTFVFAWGFFDRTHGHFHILM
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LLFLAAMVGFCFTRDMFNLFVWFEVMSVAAFALTAYHLAESSLAGAINFTVVNSLAGFLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LGGIGLIYAQTGTLDFEGIAAAVARGGRDPVVAGAFCLVATALMIKGAIVPFQFWLADAH
HCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AVAPSPVSVIFSGSMVSLGLFGLAKVSAVVFGGSDQVQQALPALLIGLGSFTALLGGWMA
HCCCCCCEEEECCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLQRHLKRMLAFSTISHAGIMLTGLGALTVDGTGGMLVYVVGHGLVKGALFMIAGILLAT
HHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
QASIDEIALRGLGRGIWPAGVAMALAGLLLCGLPLGVLDQGTRLVQGALAQQGHGIALAA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCCCCEEEEH
GAIGAALTGAAVLRAAGRIFLGLGPDPGDEAGAPSEDEREKANRPLWLMLAPCCLLLALD
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHCCCCEEHHHHHHHHHHHHH
IGLPAGLIEHALPRAASAFMHRPAVVALAEGPVWLPWASLAAALAGAGYGLFRRHLPASV
CCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCHHHHHHCCCHHH
VRPVSASQSAPTRALEVLHSGLIGDYAAWLAVGVAVIAAVLAMA
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAFPAALLPLPVAIPLVICAAMLATAHLLPGRLPDILATLSALTVAALCGVIATHAAGE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PLVYWFGGWAPRDGVHLGIGFSVDEASAWVAAFIGLLYALTFVFAWGFFDRTHGHFHILM
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LLFLAAMVGFCFTRDMFNLFVWFEVMSVAAFALTAYHLAESSLAGAINFTVVNSLAGFLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LGGIGLIYAQTGTLDFEGIAAAVARGGRDPVVAGAFCLVATALMIKGAIVPFQFWLADAH
HCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AVAPSPVSVIFSGSMVSLGLFGLAKVSAVVFGGSDQVQQALPALLIGLGSFTALLGGWMA
HCCCCCCEEEECCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLQRHLKRMLAFSTISHAGIMLTGLGALTVDGTGGMLVYVVGHGLVKGALFMIAGILLAT
HHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
QASIDEIALRGLGRGIWPAGVAMALAGLLLCGLPLGVLDQGTRLVQGALAQQGHGIALAA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCCCCEEEEH
GAIGAALTGAAVLRAAGRIFLGLGPDPGDEAGAPSEDEREKANRPLWLMLAPCCLLLALD
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHCCCCEEHHHHHHHHHHHHH
IGLPAGLIEHALPRAASAFMHRPAVVALAEGPVWLPWASLAAALAGAGYGLFRRHLPASV
CCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCHHHHHHCCCHHH
VRPVSASQSAPTRALEVLHSGLIGDYAAWLAVGVAVIAAVLAMA
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA