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The map label for this gene is pyrD [H]

Identifier: 170746981

GI number: 170746981

Start: 587559

End: 588635

Strand: Reverse

Name: pyrD [H]

Synonym: Mrad2831_0547

Alternate gene names: 170746981

Gene position: 588635-587559 (Counterclockwise)

Preceding gene: 170746982

Following gene: 170746980

Centisome position: 9.68

GC content: 76.32

Gene sequence:

>1077_bases
ATGATCGCCGCCGCCTTCCCCCTCGTCCGGCCGCTGCTCCACCGCCTCGACGCGGAGCGCGCGCACGACCTGACGCTCCG
CGCCCTGGCGCTCCTGCCCGCCGGCCCCCGGCCGGCGGACGACCCGCGCCTCGCCGTCGACCTGCTGGGCCGCCGCTTCC
CCAACCCGGTCGGCCTCGCGGCCGGATTCGACAAGGGCGCGCGCGTGCCCGACGCGCTGCTGGGCCTCGGCTTCGGCTTC
GTCGAGGTGGGCGGGGTCGTCCCGCGGCCCCAGCCCGGCAACCCCCGGCCGCGGGTGTTCCGCCTCGCCGCCGACCGCGC
CGTGATCAACCGCTTCGGCCTCAACAGCGAGGGGCTGCAGGTGGTGGCCGACAGGCTCCGCGTCCGGAGGGGCCGACCCG
GCATCGTCGGCGTCAACATCGGTGCGAACAAGGACTCCGCCGACCGCCTCGCCGACTACGCCGCCTGCACCGCCACCCTG
GCCCCGCTCGTCGACTTCGTCACGGTCAACGTCTCCTCGCCGAACACGCCGGGCCTGCGCGACTTGCAGGGCGAGGCCTT
CCTCGACGAGCTGCTCGCCCGGACGGTCGACGCCCGGGACGCGGCCGGTGCCGGCGCGGCGATCCTCCTCAAGATCGCCC
CCGACATGGCGCTGGACGCCCTCGATGCGGTCTGCGCCACGGCGCAGCGGCGCGGTGTCCAGGCCCTCGTCGTGTCGAAC
ACCACGGTGGCCCGCCCGGCGAGCCTGCGCGAGCAGGGCCTCGCCCGGGAGACCGGCGGCCTCTCGGGGCGGCCGCTCTT
CGGTCCGGCGACCCGGATGCTCGCCCAGACGCGCCTGCGCGTCGGGGAGACGCTGCCGCTCATCGGCGTCGGCGGCGTGG
ATTCGGCCGAGGCGGCCTGGACCAAGATCCGGGCCGGCGCGAGCCTCGTGCAGCTCTACTCGGCCTTGGTCTACGAGGGG
CCGGGCCTGGTCGGGCGCATCAAGGACGGGCTCCTGCGGCGCATGAATGAGGCCGGCGTCGCCTCTCTCCGGCAGGCCGT
CGGGCGCGACGCCGCCGACCTCGCCCGCGGGGACTGA

Upstream 100 bases:

>100_bases
ACCTCTACGGCCCGCTGCCGATCTCCGCCGTGGTCGCGGTGGACGAAATGCCGCTGGACGCCGACGGGCGGCACGCCTTC
CCGGCCGGGATCCTGCCGGC

Downstream 100 bases:

>100_bases
GCCGGCGCGGGCGAGCCAATCGCGGCGCCGCGGCGGACAATTTTTTTGCGGTCGCAGTTTAGAAAGGCTTTGCACAGCGG
GAGCTTAGCCTGTGTCCCGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MIAAAFPLVRPLLHRLDAERAHDLTLRALALLPAGPRPADDPRLAVDLLGRRFPNPVGLAAGFDKGARVPDALLGLGFGF
VEVGGVVPRPQPGNPRPRVFRLAADRAVINRFGLNSEGLQVVADRLRVRRGRPGIVGVNIGANKDSADRLADYAACTATL
APLVDFVTVNVSSPNTPGLRDLQGEAFLDELLARTVDARDAAGAGAAILLKIAPDMALDALDAVCATAQRRGVQALVVSN
TTVARPASLREQGLARETGGLSGRPLFGPATRMLAQTRLRVGETLPLIGVGGVDSAEAAWTKIRAGASLVQLYSALVYEG
PGLVGRIKDGLLRRMNEAGVASLRQAVGRDAADLARGD

Sequences:

>Translated_358_residues
MIAAAFPLVRPLLHRLDAERAHDLTLRALALLPAGPRPADDPRLAVDLLGRRFPNPVGLAAGFDKGARVPDALLGLGFGF
VEVGGVVPRPQPGNPRPRVFRLAADRAVINRFGLNSEGLQVVADRLRVRRGRPGIVGVNIGANKDSADRLADYAACTATL
APLVDFVTVNVSSPNTPGLRDLQGEAFLDELLARTVDARDAAGAGAAILLKIAPDMALDALDAVCATAQRRGVQALVVSN
TTVARPASLREQGLARETGGLSGRPLFGPATRMLAQTRLRVGETLPLIGVGGVDSAEAAWTKIRAGASLVQLYSALVYEG
PGLVGRIKDGLLRRMNEAGVASLRQAVGRDAADLARGD
>Mature_358_residues
MIAAAFPLVRPLLHRLDAERAHDLTLRALALLPAGPRPADDPRLAVDLLGRRFPNPVGLAAGFDKGARVPDALLGLGFGF
VEVGGVVPRPQPGNPRPRVFRLAADRAVINRFGLNSEGLQVVADRLRVRRGRPGIVGVNIGANKDSADRLADYAACTATL
APLVDFVTVNVSSPNTPGLRDLQGEAFLDELLARTVDARDAAGAGAAILLKIAPDMALDALDAVCATAQRRGVQALVVSN
TTVARPASLREQGLARETGGLSGRPLFGPATRMLAQTRLRVGETLPLIGVGGVDSAEAAWTKIRAGASLVQLYSALVYEG
PGLVGRIKDGLLRRMNEAGVASLRQAVGRDAADLARGD

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=346, Percent_Identity=47.9768786127168, Blast_Score=288, Evalue=6e-78,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=40.1197604790419, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17509475, Length=362, Percent_Identity=41.9889502762431, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI281361352, Length=348, Percent_Identity=45.4022988505747, Blast_Score=281, Evalue=4e-76,
Organism=Drosophila melanogaster, GI17137316, Length=348, Percent_Identity=45.4022988505747, Blast_Score=281, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37467; Mature: 37467

Theoretical pI: Translated: 10.84; Mature: 10.84

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAAAFPLVRPLLHRLDAERAHDLTLRALALLPAGPRPADDPRLAVDLLGRRFPNPVGLA
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEE
AGFDKGARVPDALLGLGFGFVEVGGVVPRPQPGNPRPRVFRLAADRAVINRFGLNSEGLQ
CCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCHHH
VVADRLRVRRGRPGIVGVNIGANKDSADRLADYAACTATLAPLVDFVTVNVSSPNTPGLR
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCH
DLQGEAFLDELLARTVDARDAAGAGAAILLKIAPDMALDALDAVCATAQRRGVQALVVSN
HCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEC
TTVARPASLREQGLARETGGLSGRPLFGPATRMLAQTRLRVGETLPLIGVGGVDSAEAAW
CCCCCCHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
TKIRAGASLVQLYSALVYEGPGLVGRIKDGLLRRMNEAGVASLRQAVGRDAADLARGD
HHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MIAAAFPLVRPLLHRLDAERAHDLTLRALALLPAGPRPADDPRLAVDLLGRRFPNPVGLA
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEE
AGFDKGARVPDALLGLGFGFVEVGGVVPRPQPGNPRPRVFRLAADRAVINRFGLNSEGLQ
CCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCHHH
VVADRLRVRRGRPGIVGVNIGANKDSADRLADYAACTATLAPLVDFVTVNVSSPNTPGLR
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCH
DLQGEAFLDELLARTVDARDAAGAGAAILLKIAPDMALDALDAVCATAQRRGVQALVVSN
HCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEC
TTVARPASLREQGLARETGGLSGRPLFGPATRMLAQTRLRVGETLPLIGVGGVDSAEAAW
CCCCCCHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
TKIRAGASLVQLYSALVYEGPGLVGRIKDGLLRRMNEAGVASLRQAVGRDAADLARGD
HHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA