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The map label for this gene is folP [C]

Identifier: 170746947

GI number: 170746947

Start: 550829

End: 551665

Strand: Reverse

Name: folP [C]

Synonym: Mrad2831_0513

Alternate gene names: 170746947

Gene position: 551665-550829 (Counterclockwise)

Preceding gene: 170746948

Following gene: 170746946

Centisome position: 9.08

GC content: 72.52

Gene sequence:

>837_bases
GTGACCCCCTCCTCCCGCCTGTCCGACCTGCTGCCCGCCCTCGGCGGCCGCACGCTGGTCATGGGCATCCTCAACGTCAC
GCCCGATTCCTTCTCGGATGGCGGCCTCTTCGCCGGGGAGGCCGAGGCGGTGACCCAGGCCGAACGGCTGGTCGCTGAGG
GTGCGGCGATCCTCGACGTCGGGGGGGAATCGACGCGGCCCGGCCACGTTCCTGTCCCCGCCGAGGAGGAGCAGGCCCGC
GTCGTGCCGGTCATCCGGGCCGTGGCGCCGCGGCTGCCGGTGCCGATCTCCATCGACACCTACAAGGCCTCGACCGCGCG
CGTCGCGCTGGAGGCGGGCGCGCGGATCGTCAACGACGTCTGGGGCCTCCAGCGCGAGCCCGACATCGCCACCGTGGCGG
CCGCGCACGGCGCACCGGTCATCATCATGCACAACCGCGAGACGATTGAGCCGGATCTCGACATCGTCGCCGACATGCTG
GCCTTCTTCGAGCGATCGCTGGCGATCGCCCACCGCGCGGGTCTCGCCGATTCGGAGATCGTGCTCGACCCGGGGGTCGG
CTTCGGCAAGACCTGGAATCAGCATCTCGAGGCGCTGCGCCGGCTGCCCGAGATCCGCGCCCTCGGATTCCCGGTCTTGG
TCGGCGTGTCCCGCAAGTCGCTCCTCGGCCGCCTGCACGACCGCGAGACCCGTCCGACGGACCGCCTGCACGGGTCCCTC
GCCGCCCACGCCGTCGCGGCGACCCTCGGGGCCGACATCGTGCGCGTGCACGACGTCGCGGCGCATATCGACGCGATGCG
TGTCGTCGACGCCGTGATGCGGCCGGAGGCGCGCTGA

Upstream 100 bases:

>100_bases
CTGCTATCGCGGCTGAATCGAACGGCGAGGCCGGCGTTGCGCCGGCCTCCCGATTCGCGCACACCGGCTCCCGAACCGCG
TTCGTGAACGGGACCCGCCT

Downstream 100 bases:

>100_bases
GCATGGCGGGCGACCTAATCCGCGTCACCCGGATCGCCGTGTTCGGCCGGCACGGCGTGCTGGCCGAGGAGGCGGTGCTC
GGCCAGCGATTCTACATCTC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTPSSRLSDLLPALGGRTLVMGILNVTPDSFSDGGLFAGEAEAVTQAERLVAEGAAILDVGGESTRPGHVPVPAEEEQAR
VVPVIRAVAPRLPVPISIDTYKASTARVALEAGARIVNDVWGLQREPDIATVAAAHGAPVIIMHNRETIEPDLDIVADML
AFFERSLAIAHRAGLADSEIVLDPGVGFGKTWNQHLEALRRLPEIRALGFPVLVGVSRKSLLGRLHDRETRPTDRLHGSL
AAHAVAATLGADIVRVHDVAAHIDAMRVVDAVMRPEAR

Sequences:

>Translated_278_residues
MTPSSRLSDLLPALGGRTLVMGILNVTPDSFSDGGLFAGEAEAVTQAERLVAEGAAILDVGGESTRPGHVPVPAEEEQAR
VVPVIRAVAPRLPVPISIDTYKASTARVALEAGARIVNDVWGLQREPDIATVAAAHGAPVIIMHNRETIEPDLDIVADML
AFFERSLAIAHRAGLADSEIVLDPGVGFGKTWNQHLEALRRLPEIRALGFPVLVGVSRKSLLGRLHDRETRPTDRLHGSL
AAHAVAATLGADIVRVHDVAAHIDAMRVVDAVMRPEAR
>Mature_277_residues
TPSSRLSDLLPALGGRTLVMGILNVTPDSFSDGGLFAGEAEAVTQAERLVAEGAAILDVGGESTRPGHVPVPAEEEQARV
VPVIRAVAPRLPVPISIDTYKASTARVALEAGARIVNDVWGLQREPDIATVAAAHGAPVIIMHNRETIEPDLDIVADMLA
FFERSLAIAHRAGLADSEIVLDPGVGFGKTWNQHLEALRRLPEIRALGFPVLVGVSRKSLLGRLHDRETRPTDRLHGSLA
AHAVAATLGADIVRVHDVAAHIDAMRVVDAVMRPEAR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=260, Percent_Identity=46.1538461538462, Blast_Score=212, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=29.9382716049383, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29566; Mature: 29435

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSSRLSDLLPALGGRTLVMGILNVTPDSFSDGGLFAGEAEAVTQAERLVAEGAAILDV
CCCHHHHHHHHHHHCCCEEEHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEC
GGESTRPGHVPVPAEEEQARVVPVIRAVAPRLPVPISIDTYKASTARVALEAGARIVNDV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHH
WGLQREPDIATVAAAHGAPVIIMHNRETIEPDLDIVADMLAFFERSLAIAHRAGLADSEI
HCCCCCCCHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VLDPGVGFGKTWNQHLEALRRLPEIRALGFPVLVGVSRKSLLGRLHDRETRPTDRLHGSL
EECCCCCCCCCHHHHHHHHHHCCHHHHCCCHHEECCCHHHHHHHHHCCCCCCHHHHHHHH
AAHAVAATLGADIVRVHDVAAHIDAMRVVDAVMRPEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TPSSRLSDLLPALGGRTLVMGILNVTPDSFSDGGLFAGEAEAVTQAERLVAEGAAILDV
CCHHHHHHHHHHHCCCEEEHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEC
GGESTRPGHVPVPAEEEQARVVPVIRAVAPRLPVPISIDTYKASTARVALEAGARIVNDV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHH
WGLQREPDIATVAAAHGAPVIIMHNRETIEPDLDIVADMLAFFERSLAIAHRAGLADSEI
HCCCCCCCHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VLDPGVGFGKTWNQHLEALRRLPEIRALGFPVLVGVSRKSLLGRLHDRETRPTDRLHGSL
EECCCCCCCCCHHHHHHHHHHCCHHHHCCCHHEECCCHHHHHHHHHCCCCCCHHHHHHHH
AAHAVAATLGADIVRVHDVAAHIDAMRVVDAVMRPEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]