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The map label for this gene is thiE [H]

Identifier: 170746605

GI number: 170746605

Start: 155069

End: 155725

Strand: Reverse

Name: thiE [H]

Synonym: Mrad2831_0155

Alternate gene names: 170746605

Gene position: 155725-155069 (Counterclockwise)

Preceding gene: 170746606

Following gene: 170746604

Centisome position: 2.56

GC content: 73.21

Gene sequence:

>657_bases
TTGCCGGTTTCGATGAGCAATAGCGCCCGTCTCGCCCTGCTCGGACCGCACGGTCTCGAAGCGGAAGGCATCGCCGCTTT
CGTGACGGCCCTGAAGGTTGCGTGCGAAGCCGGCGATGTCGCCGCCGTGATTCTGCGGCTGGCTGCCACCGACGAGCGCG
GGCTGACGGCCCGCGTCAAATCGGTCGCTCCGCTCGTGCAGGAGCGCGGCGCGGCCCTGGTCGTTGCCTGTCCGGGTTTC
GCCGGCGATCTCGCCGCGGTGGCGATCCGGGGCGGCGCCGACGGCATCCACGTCGACAAGCCGCGCGACCTGAAGGACCT
GCGCGGCCGGCTCCGGGAGGGGCGAATCCTCGGCGCCGGCGGCCTCGAGACCAAGCACGGCGCGATGGAGGCCGGCGAGG
CCGGGATCGACTACCTGATGTTCGGTGGTCTGTACCCGGACGGCGTCGCGCCCGAGGCGGAGACCGTGCGGGCCCGCGCC
GCGTGGTGGGCCGAGATCTTCGAGACACCGTGCATCGCGGTGGCGGCTGCCGCCGATGAGATCGCGCCTCTCGCCGCGAC
GGGTGCCGAGTTCGTCGGCCTGGAGAGCGGCCTCTGGCTGCCGGATCCGGGCGCGGTCGAGCGGGCCCAGCGCGCCGTCC
GGGAGTCCGAGGCGTGA

Upstream 100 bases:

>100_bases
GCAAGGGCTCGAAGATCCGCCCGATCTCCGTCGCCGAGATGGCCAAGCGCTACGCCAGCGGCGCCCTCGACCCGAAGATC
GGGCCGCAGTAGGGCGCGGG

Downstream 100 bases:

>100_bases
GAGGCCGCGACGTCCGTCGTCTGGCGGCCTTCGCCGGCGCGGCGCTGCTGGCGCTGCCGGCCTGGGCGGCCTCGGGACCG
GCCGATCCGGCCCGGACCGC

Product: thiamine monophosphate synthase

Products: NA

Alternate protein names: TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MPVSMSNSARLALLGPHGLEAEGIAAFVTALKVACEAGDVAAVILRLAATDERGLTARVKSVAPLVQERGAALVVACPGF
AGDLAAVAIRGGADGIHVDKPRDLKDLRGRLREGRILGAGGLETKHGAMEAGEAGIDYLMFGGLYPDGVAPEAETVRARA
AWWAEIFETPCIAVAAAADEIAPLAATGAEFVGLESGLWLPDPGAVERAQRAVRESEA

Sequences:

>Translated_218_residues
MPVSMSNSARLALLGPHGLEAEGIAAFVTALKVACEAGDVAAVILRLAATDERGLTARVKSVAPLVQERGAALVVACPGF
AGDLAAVAIRGGADGIHVDKPRDLKDLRGRLREGRILGAGGLETKHGAMEAGEAGIDYLMFGGLYPDGVAPEAETVRARA
AWWAEIFETPCIAVAAAADEIAPLAATGAEFVGLESGLWLPDPGAVERAQRAVRESEA
>Mature_217_residues
PVSMSNSARLALLGPHGLEAEGIAAFVTALKVACEAGDVAAVILRLAATDERGLTARVKSVAPLVQERGAALVVACPGFA
GDLAAVAIRGGADGIHVDKPRDLKDLRGRLREGRILGAGGLETKHGAMEAGEAGIDYLMFGGLYPDGVAPEAETVRARAA
WWAEIFETPCIAVAAAADEIAPLAATGAEFVGLESGLWLPDPGAVERAQRAVRESEA

Specific function: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [H]

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: =2.5.1.3 [H]

Molecular weight: Translated: 22387; Mature: 22256

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSMSNSARLALLGPHGLEAEGIAAFVTALKVACEAGDVAAVILRLAATDERGLTARVK
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHH
SVAPLVQERGAALVVACPGFAGDLAAVAIRGGADGIHVDKPRDLKDLRGRLREGRILGAG
HHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCEEEECC
GLETKHGAMEAGEAGIDYLMFGGLYPDGVAPEAETVRARAAWWAEIFETPCIAVAAAADE
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEHHHHH
IAPLAATGAEFVGLESGLWLPDPGAVERAQRAVRESEA
HHHHHHCCHHHEECCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVSMSNSARLALLGPHGLEAEGIAAFVTALKVACEAGDVAAVILRLAATDERGLTARVK
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHH
SVAPLVQERGAALVVACPGFAGDLAAVAIRGGADGIHVDKPRDLKDLRGRLREGRILGAG
HHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCEEEECC
GLETKHGAMEAGEAGIDYLMFGGLYPDGVAPEAETVRARAAWWAEIFETPCIAVAAAADE
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEHHHHH
IAPLAATGAEFVGLESGLWLPDPGAVERAQRAVRESEA
HHHHHHCCHHHEECCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA