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The map label for this gene is gmk

Identifier: 170762310

GI number: 170762310

Start: 256155

End: 256730

Strand: Direct

Name: gmk

Synonym: UPA3_0220

Alternate gene names: 170762310

Gene position: 256155-256730 (Clockwise)

Preceding gene: 170761895

Following gene: 170761929

Centisome position: 34.08

GC content: 25.52

Gene sequence:

>576_bases
ATGAAACGCGGAAAATTAATTGTTTTTAGTGGACCTAGTGGTGTAGGAAAACATACAATTCTATCTAAAATCATAAATCG
TAAAGATTTAAATTTAGCATATAGTATTTCAATGACAACCCGAAAAAAACGTGAAGGTGAAGTTAATGGTGTTGATTATT
ATTTTGTTAATGATGAAGAATTTAAAAAGGCCATACTAAATAATGAATTAATTGAGTGAGCTGAGTTTGTTGGAAATAAA
TATGGAACACCACGAACTATTGTTGAAAAATTAAGAGATGAAGGAAAAAATGTTATTTTAGAAATTGAGGTTGTAGGTGC
ACTTAAAGTTTTAGATTTATATAAAAATGATGATTTAATTTCTATTTTTTTATTACCACCAAGTATTGATGAATTAAAAA
AACGCTTATTAAAAAGGAATACAGAAACATTAGAAACAATTAAAAAAAGAATTCAAAAAGCTACTCATGAAATAACAATA
AAAGATTATTATCAATATAATATTATTAATGATAATCCAGATCATGCAGCAAACCAGTTGGCGGAGATTATTCTAAATGA
AATTAAACAATCATAA

Upstream 100 bases:

>100_bases
AGTTGTAAATTTATTCAAAATTAGAGATGTAAAATTACTAAATTTTAAAAACATTGGTATTAATAATAACCATAAAAATA
AAAAAGAGGAGTTTTAATTT

Downstream 100 bases:

>100_bases
TCTAAAAGAAATTTATTCATTATCATTAAATGAACTTAAAGAAGAATTATTTAAATTAGGCTTAAAATCTTTTATTAGCA
AACAAATTTATTCTTGGATT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKRGKLIVFSGPSGVGKHTILSKIINRKDLNLAYSISMTTRKKREGEVNGVDYYFVNDEEFKKAILNNELIEWAEFVGNK
YGTPRTIVEKLRDEGKNVILEIEVVGALKVLDLYKNDDLISIFLLPPSIDELKKRLLKRNTETLETIKKRIQKATHEITI
KDYYQYNIINDNPDHAANQLAEIILNEIKQS

Sequences:

>Translated_191_residues
MKRGKLIVFSGPSGVGKHTILSKIINRKDLNLAYSISMTTRKKREGEVNGVDYYFVNDEEFKKAILNNELIE*AEFVGNK
YGTPRTIVEKLRDEGKNVILEIEVVGALKVLDLYKNDDLISIFLLPPSIDELKKRLLKRNTETLETIKKRIQKATHEITI
KDYYQYNIINDNPDHAANQLAEIILNEIKQS
>Mature_191_residues
MKRGKLIVFSGPSGVGKHTILSKIINRKDLNLAYSISMTTRKKREGEVNGVDYYFVNDEEFKKAILNNELIE*AEFVGNK
YGTPRTIVEKLRDEGKNVILEIEVVGALKVLDLYKNDDLISIFLLPPSIDELKKRLLKRNTETLETIKKRIQKATHEITI
KDYYQYNIINDNPDHAANQLAEIILNEIKQS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=196, Percent_Identity=36.734693877551, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI226874833, Length=196, Percent_Identity=36.734693877551, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4504221, Length=196, Percent_Identity=36.734693877551, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI38570142, Length=186, Percent_Identity=30.1075268817204, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI186972120, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI186700629, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI186700627, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=25.7731958762887, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI119943106, Length=155, Percent_Identity=30.3225806451613, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI262118255, Length=178, Percent_Identity=26.9662921348315, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI262118263, Length=178, Percent_Identity=26.9662921348315, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI4505237, Length=178, Percent_Identity=26.9662921348315, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI262118259, Length=178, Percent_Identity=26.9662921348315, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=188, Percent_Identity=39.3617021276596, Blast_Score=125, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=191, Percent_Identity=35.6020942408377, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI193203132, Length=191, Percent_Identity=35.6020942408377, Blast_Score=113, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71984092, Length=119, Percent_Identity=36.1344537815126, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988048, Length=131, Percent_Identity=34.3511450381679, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71988041, Length=131, Percent_Identity=34.3511450381679, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=42.0765027322404, Blast_Score=133, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356141, Length=193, Percent_Identity=40.4145077720207, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45554481, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85816106, Length=133, Percent_Identity=35.3383458646617, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85816281, Length=133, Percent_Identity=35.3383458646617, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640542, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85724806, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554489, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077626, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007136, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551002, Length=133, Percent_Identity=35.3383458646617, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21802; Mature: 21802

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGKLIVFSGPSGVGKHTILSKIINRKDLNLAYSISMTTRKKREGEVNGVDYYFVNDEE
CCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCCCCCEEEEEECHHH
FKKAILNNELIEAEFVGNKYGTPRTIVEKLRDEGKNVILEIEVVGALKVLDLYKNDDLIS
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEECCEEEHHHHCCCCEEE
IFLLPPSIDELKKRLLKRNTETLETIKKRIQKATHEITIKDYYQYNIINDNPDHAANQLA
EEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCCHHHHHHH
EIILNEIKQS
HHHHHHHHCC
>Mature Secondary Structure
MKRGKLIVFSGPSGVGKHTILSKIINRKDLNLAYSISMTTRKKREGEVNGVDYYFVNDEE
CCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCCCCCEEEEEECHHH
FKKAILNNELIEAEFVGNKYGTPRTIVEKLRDEGKNVILEIEVVGALKVLDLYKNDDLIS
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEECCEEEHHHHCCCCEEE
IFLLPPSIDELKKRLLKRNTETLETIKKRIQKATHEITIKDYYQYNIINDNPDHAANQLA
EEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCCHHHHHHH
EIILNEIKQS
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]