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The map label for this gene is hpt

Identifier: 170762285

GI number: 170762285

Start: 132261

End: 132881

Strand: Direct

Name: hpt

Synonym: UPA3_0107

Alternate gene names: 170762285

Gene position: 132261-132881 (Clockwise)

Preceding gene: 170762072

Following gene: 170761853

Centisome position: 17.6

GC content: 27.7

Gene sequence:

>621_bases
ATGATTAAAAATCAAAAAACAAGAAATGATGGTATAAAAATGAAAGATATTGATCCAAGAATAAAAGAGGTTTTGATCAC
TGAAGAACAAATTGATCAAAAAATCACTGAAGCAGCTAATTGAATCAATAAGGAATATGAAGGTAAAGAACCAATTATAA
TTGGTATTTTAAAAGGATGCATTCCATTTATTGGCAAATTATTACCAAAAATTAAAATTGACATGAAACTAGATTTTTTA
GCAATTAGTAGTTTTAAGGGAGCAACTAGTGCTCAAACAGAACCAGAAATTATTACTGATCTTAAATTTGAAGTTAAAGA
TCGTGATCTAATTTTAGTAGAAGATATTGTTGATACAGGACGCACAATTAAAAAGGTTTATGATTTACTTAAAATTCGAG
GCGCTCGTTCAATTAAATTAGTTACCTTGGTTGATAAAAAAGACGGCCGATTAGTAGATTTACAAGCCGATTTTGTATGT
TGTGATATTCCATTAGTCTTTATTGTTGGTTTTGGTTTAGATTATAAAGAAATTATGCGTAATTTACCATATATTGGTGT
TTTAAAAGAAGAAGTTTATCAAAATGATTTAAATAATAAAAACGAAGGGGATGGAGAGTAA

Upstream 100 bases:

>100_bases
AGGTAAGTAATAAACCAGATATTTTAATAAAAGAGTTTAAAATAAACTATTTTATGCCTAATTACTTTAAATAATAATAA
TTACTTAATGGTATAATAGT

Downstream 100 bases:

>100_bases
TTAGATGTATTTTTTAAAAAAAATAGTAAATTTATTTAGTTCAAAAATTGAATCAGAAGATAATAATGTTAAAAAAGACG
ACTTAACTCAACCACGTAAA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MIKNQKTRNDGIKMKDIDPRIKEVLITEEQIDQKITEAANWINKEYEGKEPIIIGILKGCIPFIGKLLPKIKIDMKLDFL
AISSFKGATSAQTEPEIITDLKFEVKDRDLILVEDIVDTGRTIKKVYDLLKIRGARSIKLVTLVDKKDGRLVDLQADFVC
CDIPLVFIVGFGLDYKEIMRNLPYIGVLKEEVYQNDLNNKNEGDGE

Sequences:

>Translated_206_residues
MIKNQKTRNDGIKMKDIDPRIKEVLITEEQIDQKITEAAN*INKEYEGKEPIIIGILKGCIPFIGKLLPKIKIDMKLDFL
AISSFKGATSAQTEPEIITDLKFEVKDRDLILVEDIVDTGRTIKKVYDLLKIRGARSIKLVTLVDKKDGRLVDLQADFVC
CDIPLVFIVGFGLDYKEIMRNLPYIGVLKEEVYQNDLNNKNEGDGE
>Mature_206_residues
MIKNQKTRNDGIKMKDIDPRIKEVLITEEQIDQKITEAAN*INKEYEGKEPIIIGILKGCIPFIGKLLPKIKIDMKLDFL
AISSFKGATSAQTEPEIITDLKFEVKDRDLILVEDIVDTGRTIKKVYDLLKIRGARSIKLVTLVDKKDGRLVDLQADFVC
CDIPLVFIVGFGLDYKEIMRNLPYIGVLKEEVYQNDLNNKNEGDGE

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=161, Percent_Identity=31.055900621118, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI9910262, Length=180, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=34.3373493975904, Blast_Score=117, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17510817, Length=159, Percent_Identity=32.0754716981132, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 23253; Mature: 23253

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKNQKTRNDGIKMKDIDPRIKEVLITEEQIDQKITEAANINKEYEGKEPIIIGILKGCI
CCCCCCCCCCCCEECCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHH
PFIGKLLPKIKIDMKLDFLAISSFKGATSAQTEPEIITDLKFEVKDRDLILVEDIVDTGR
HHHHHHHCCEEECEEEEEEEEECCCCCCCCCCCCCHHHCCEEEECCCCEEEEHHHHHCCH
TIKKVYDLLKIRGARSIKLVTLVDKKDGRLVDLQADFVCCDIPLVFIVGFGLDYKEIMRN
HHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCEEEECCHHHHHHHCCCCHHHHHHH
LPYIGVLKEEVYQNDLNNKNEGDGE
CCCEEHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIKNQKTRNDGIKMKDIDPRIKEVLITEEQIDQKITEAANINKEYEGKEPIIIGILKGCI
CCCCCCCCCCCCEECCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHH
PFIGKLLPKIKIDMKLDFLAISSFKGATSAQTEPEIITDLKFEVKDRDLILVEDIVDTGR
HHHHHHHCCEEECEEEEEEEEECCCCCCCCCCCCCHHHCCEEEECCCCEEEEHHHHHCCH
TIKKVYDLLKIRGARSIKLVTLVDKKDGRLVDLQADFVCCDIPLVFIVGFGLDYKEIMRN
HHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCEEEECCHHHHHHHCCCCHHHHHHH
LPYIGVLKEEVYQNDLNNKNEGDGE
CCCEEHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12354221 [H]