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The map label for this gene is map

Identifier: 170762236

GI number: 170762236

Start: 287770

End: 288519

Strand: Direct

Name: map

Synonym: UPA3_0260

Alternate gene names: 170762236

Gene position: 287770-288519 (Clockwise)

Preceding gene: 170762193

Following gene: 170762355

Centisome position: 38.28

GC content: 30.67

Gene sequence:

>750_bases
ATGGTTATTGTTAAAACAGAAAAAGATATTGCTGCTATTAAAGAAGCTGTGCGAATTTGAAAAATTGCTCGTGAAGCAAT
TTATAAACAAGCTAAAGCAGGCGTTTCATTAAAAGAATTAGACTTATTAGCTAAAGAAGTTATTGAAGCAAATGGTGGAA
TTGCTGCTTTTCACAACTATTTAGGTTTTAAAGGTCATATTTGTATTTCAGTGAATGAGTGCGTTATTCATGGAGTCCCA
ACCGATTACGTCTTAAAAGATGGTGATAAGGTAACATTTGATGTTGGTGTTAAATACGATAATCATTATTGTGATGCGGC
GTTTACCATTATTATTAACAACTCAAATGTTGAAGCACTAAAAATATCAGAGATTTGTAAAAAATCAATTGACGAAGCCG
TTGCAATTATTAAACCAAAAGTAACAACACATGCAATTTCGAATGCAATTCAAAAGTTTATTGAAAAAAACGGTTATTTT
GTTCTTCGTGATTTTGCCGGCCACGGTTGTGGTAATGAAATTCATGAAGATCCATTGATTCCTAATTATCGATCTTTATT
GTATCGTAATGTTACATTAGAAGAGAATATGGTAATTTGTATTGAACCAATGATTCTAAGTGGATCAAATGCTTATTATA
TTGATCCAAACGATCAATGATCTGTAAAATCTAAAAATCATCAAATGACTTGTCATTGAGAACATATGATTCTAATTACA
AAAGATGGTTGTGAAGTTTTAACAGATTAA

Upstream 100 bases:

>100_bases
TATTAAAATCAATGCTAATCAACCTATTGAAGATGTTTATAAAAACATTAACAATTATTTAAAACAAAATAAGTAAAAAA
AAGTAGATGAAGTTAAAACC

Downstream 100 bases:

>100_bases
GGGATATATTTTAAACAAGGAATAAAAATGGCAGATACAGAAAAATTAAAAATGCTTGGTAAAATTGTTGAAGTTTTACA
AGGCGGAAATTTTAGAGTTC

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MVIVKTEKDIAAIKEAVRIWKIAREAIYKQAKAGVSLKELDLLAKEVIEANGGIAAFHNYLGFKGHICISVNECVIHGVP
TDYVLKDGDKVTFDVGVKYDNHYCDAAFTIIINNSNVEALKISEICKKSIDEAVAIIKPKVTTHAISNAIQKFIEKNGYF
VLRDFAGHGCGNEIHEDPLIPNYRSLLYRNVTLEENMVICIEPMILSGSNAYYIDPNDQWSVKSKNHQMTCHWEHMILIT
KDGCEVLTD

Sequences:

>Translated_249_residues
MVIVKTEKDIAAIKEAVRI*KIAREAIYKQAKAGVSLKELDLLAKEVIEANGGIAAFHNYLGFKGHICISVNECVIHGVP
TDYVLKDGDKVTFDVGVKYDNHYCDAAFTIIINNSNVEALKISEICKKSIDEAVAIIKPKVTTHAISNAIQKFIEKNGYF
VLRDFAGHGCGNEIHEDPLIPNYRSLLYRNVTLEENMVICIEPMILSGSNAYYIDPNDQ*SVKSKNHQMTCH*EHMILIT
KDGCEVLTD
>Mature_249_residues
MVIVKTEKDIAAIKEAVRI*KIAREAIYKQAKAGVSLKELDLLAKEVIEANGGIAAFHNYLGFKGHICISVNECVIHGVP
TDYVLKDGDKVTFDVGVKYDNHYCDAAFTIIINNSNVEALKISEICKKSIDEAVAIIKPKVTTHAISNAIQKFIEKNGYF
VLRDFAGHGCGNEIHEDPLIPNYRSLLYRNVTLEENMVICIEPMILSGSNAYYIDPNDQ*SVKSKNHQMTCH*EHMILIT
KDGCEVLTD

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI164420681, Length=237, Percent_Identity=29.1139240506329, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=34.5528455284553, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=25.0980392156863, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=241, Percent_Identity=30.7053941908714, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323273, Length=217, Percent_Identity=32.258064516129, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355531, Length=237, Percent_Identity=28.6919831223629, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=27.5303643724696, Blast_Score=98, Evalue=4e-21,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27315; Mature: 27315

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIVKTEKDIAAIKEAVRIKIAREAIYKQAKAGVSLKELDLLAKEVIEANGGIAAFHNYL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEHHHHC
GFKGHICISVNECVIHGVPTDYVLKDGDKVTFDVGVKYDNHYCDAAFTIIINNSNVEALK
CCCCEEEEEECCEEEECCCCCEEEECCCEEEEEEEEEECCEEECEEEEEEEECCCCCEEE
ISEICKKSIDEAVAIIKPKVTTHAISNAIQKFIEKNGYFVLRDFAGHGCGNEIHEDPLIP
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
NYRSLLYRNVTLEENMVICIEPMILSGSNAYYIDPNDQSVKSKNHQMTCHEHMILITKDG
CHHHHHEECCEECCCEEEEEEEEEECCCCEEEECCCCCHHHCCCCCEEEEEEEEEEECCC
CEVLTD
CCCCCC
>Mature Secondary Structure
MVIVKTEKDIAAIKEAVRIKIAREAIYKQAKAGVSLKELDLLAKEVIEANGGIAAFHNYL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEHHHHC
GFKGHICISVNECVIHGVPTDYVLKDGDKVTFDVGVKYDNHYCDAAFTIIINNSNVEALK
CCCCEEEEEECCEEEECCCCCEEEECCCEEEEEEEEEECCEEECEEEEEEEECCCCCEEE
ISEICKKSIDEAVAIIKPKVTTHAISNAIQKFIEKNGYFVLRDFAGHGCGNEIHEDPLIP
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
NYRSLLYRNVTLEENMVICIEPMILSGSNAYYIDPNDQSVKSKNHQMTCHEHMILITKDG
CHHHHHEECCEECCCEEEEEEEEEECCCCEEEECCCCCHHHCCCCCEEEEEEEEEEECCC
CEVLTD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10867916; 12949158 [H]