Click here to switch to the map view.

The map label for this gene is folA

Identifier: 170761955

GI number: 170761955

Start: 150399

End: 150869

Strand: Direct

Name: folA

Synonym: UPA3_0119

Alternate gene names: 170761955

Gene position: 150399-150869 (Clockwise)

Preceding gene: 170762339

Following gene: 170762233

Centisome position: 20.01

GC content: 21.66

Gene sequence:

>471_bases
ATGTTAAAGTTAATTTGATGTCAAACATTGAATGGTGGTATATCAAAAAATAATAAATTACCATGATATATAAAAGAAGA
ATTAGATCATTTTTATAAAACAACAAAAAACCATAAAATTATAATGGGTAAAAACACTTTTGATTCATTAGATCAAAAAC
CATTAAATAATCGAACAAATATCATTTTTTCTTCAATTATGCAAACACCAGAAGACGAATCGTATTTTGTGACAAATGAT
TTTCAACAAGTATTAAACGATGCTAAAAAAGAGGATATTTTTATTATTGGCGGCAAGGAATTATTTGATATTTTTTTAGC
TTATGCAGATGTTTTAATTGTTTCTGTATTAAAAGATTATTATGATTGTGATCTATACATGAAAGTTGATTATAATAATT
TTAATTTAGATAAACAAGATGTTTATGATAATTTTATTGTTAATTATTATTCAAATAAGAAGGAAAAATAA

Upstream 100 bases:

>100_bases
TAAATAATATATTTTTTAATATATATCAGTCTAATTTAAATAAATTAGTATATAATCAAAATGTGACAATCATTTATGAT
TAAGGATTTTATATTTAAAT

Downstream 100 bases:

>100_bases
AAGATTTATGACCAAAAAACTGATTGTTTTTGATTTTGATGGTACAATTATGCACACGCATACAACTATGAGCCTATCTA
TTATTGGTGTTTTAGAATTT

Product: dihydrofolate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MLKLIWCQTLNGGISKNNKLPWYIKEELDHFYKTTKNHKIIMGKNTFDSLDQKPLNNRTNIIFSSIMQTPEDESYFVTND
FQQVLNDAKKEDIFIIGGKELFDIFLAYADVLIVSVLKDYYDCDLYMKVDYNNFNLDKQDVYDNFIVNYYSNKKEK

Sequences:

>Translated_156_residues
MLKLI*CQTLNGGISKNNKLP*YIKEELDHFYKTTKNHKIIMGKNTFDSLDQKPLNNRTNIIFSSIMQTPEDESYFVTND
FQQVLNDAKKEDIFIIGGKELFDIFLAYADVLIVSVLKDYYDCDLYMKVDYNNFNLDKQDVYDNFIVNYYSNKKEK
>Mature_156_residues
MLKLI*CQTLNGGISKNNKLP*YIKEELDHFYKTTKNHKIIMGKNTFDSLDQKPLNNRTNIIFSSIMQTPEDESYFVTND
FQQVLNDAKKEDIFIIGGKELFDIFLAYADVLIVSVLKDYYDCDLYMKVDYNNFNLDKQDVYDNFIVNYYSNKKEK

Specific function: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis [H]

COG id: COG0262

COG function: function code H; Dihydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DHFR (dihydrofolate reductase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012259
- InterPro:   IPR001796 [H]

Pfam domain/function: PF00186 DHFR_1 [H]

EC number: =1.5.1.3 [H]

Molecular weight: Translated: 18126; Mature: 18126

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLICQTLNGGISKNNKLPYIKEELDHFYKTTKNHKIIMGKNTFDSLDQKPLNNRTNII
CHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCHHHHH
FSSIMQTPEDESYFVTNDFQQVLNDAKKEDIFIIGGKELFDIFLAYADVLIVSVLKDYYD
HHHHHCCCCCCCEEEHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHC
CDLYMKVDYNNFNLDKQDVYDNFIVNYYSNKKEK
CEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLKLICQTLNGGISKNNKLPYIKEELDHFYKTTKNHKIIMGKNTFDSLDQKPLNNRTNII
CHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCHHHHH
FSSIMQTPEDESYFVTNDFQQVLNDAKKEDIFIIGGKELFDIFLAYADVLIVSVLKDYYD
HHHHHCCCCCCCEEEHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHC
CDLYMKVDYNNFNLDKQDVYDNFIVNYYSNKKEK
CEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]