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The map label for this gene is lolE [H]

Identifier: 170682380

GI number: 170682380

Start: 2027946

End: 2029190

Strand: Reverse

Name: lolE [H]

Synonym: EcSMS35_2008

Alternate gene names: 170682380

Gene position: 2029190-2027946 (Counterclockwise)

Preceding gene: 170679953

Following gene: 170682022

Centisome position: 40.04

GC content: 52.13

Gene sequence:

>1245_bases
ATGGCGATGCCTTTATCGTTATTAATTGGCCTGCGTTTTAGTCGCGGACGGCGGCGCGGCGGCATGGTGTCGCTGATCTC
CGTCATTTCTACCATCGGCATTGCCCTCGGCGTGGCGGTATTGATCGTCGGCTTAAGCGCGATGAACGGCTTTGAACGCG
AACTGAATAACCGCATTCTGGCGGTGGTGCCGCATGGTGAAATCGAAGCGGTGGATCAGCCGTGGACTAACTGGCAGGAA
GCACTGGATAACGTGCAGAAAGTGCCGGGTATTGCCGCCGCTGCGCCGTATATCAATTTCACCGGGCTGGTGGAAAGTGG
CGCGAATCTGCGCGCAATCCAGGTGAAGGGCGTTAACCCGCAACAGGAACAGCGTCTGAGCGCATTACCCTCGTTTGTTC
AGGGGGATGCCTGGCGCAATTTTAAAGCGGGCGAACAGCAAATTATCATCGGCAAAGGCGTGGCGGATGCGCTGAAAGTG
AAGCAGGGCGATTGGGTGTCGATTATGATCCCCAACTCGAATCCTGAGCATAAACTGATGCAGCCAAAACGTGTGCGTTT
GCACGTTGCCGGTATTTTGCAGTTGAGTGGTCAACTCGATCACAGTTTTGCCATGATCCCGCTGGCGGATGCCCAACAAT
ATCTTGATATGGGTTCCAGCGTGTCAGGTATTGCCCTTAAAATGACGGATGTTTTCAACGCCAATAAGCTGGTACGCGAT
GCGGGTGAAGTGACCAACAGCTATGTTTATATTAAAAGCTGGATTGGTACTTACGGCTATATGTATCGCGATATCCAGAT
GATCCGCGCCATTATGTATCTGGCGATGGTACTGGTGATTGGCGTGGCCTGTTTCAACATCGTCTCCACCTTAGTGATGG
CGGTGAAAGACAAGAGTGGCGATATCGCAGTATTAAGAACGCTGGGGGCGAAAGATGGTTTAATTCGCGCCATCTTTGTC
TGGTATGGATTGCTGGCAGGGCTGTTCGGCAGCCTGTGTGGGGTGATTATCGGCGTAGTGGTTTCACTGCAACTTACCCC
GATTATTGAGTGGATTGAAAAGCTGATCGGTCATCAGTTCCTCTCCAGCGATATCTATTTTATTGACTTCTTGCCATCGG
AATTGCACTGGCTGGACGTCTTCTACGTACTGGTCACAGCATTGTTGCTGAGTCTTTTGGCAAGTTGGTATCCGGCGCGG
CGCGCCAGTAATATTGACCCTGCGCGAGTCCTTAGCGGCCAGTAA

Upstream 100 bases:

>100_bases
TGGTTACTCACGACCTGCAACTGGCGAAACGTATGAGCCGCCAACTGGAGATGCGTGATGGTCGTCTGACGGCGGAACTG
AGCCTGATGGGGGCGGAGTA

Downstream 100 bases:

>100_bases
AGGCAGTACATTAAAACAAGGAGCGGCAATGTATTACGGGTTTGATATTGGTGGAACAAAAATTGCGCTAGGCGTGTTTG
ATAGCGGTCGGCAGTTGCAG

Product: outer membrane-specific lipoprotein transporter subunit LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MAMPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVDQPWTNWQE
ALDNVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVNPQQEQRLSALPSFVQGDAWRNFKAGEQQIIIGKGVADALKV
KQGDWVSIMIPNSNPEHKLMQPKRVRLHVAGILQLSGQLDHSFAMIPLADAQQYLDMGSSVSGIALKMTDVFNANKLVRD
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFV
WYGLLAGLFGSLCGVIIGVVVSLQLTPIIEWIEKLIGHQFLSSDIYFIDFLPSELHWLDVFYVLVTALLLSLLASWYPAR
RASNIDPARVLSGQ

Sequences:

>Translated_414_residues
MAMPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVDQPWTNWQE
ALDNVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVNPQQEQRLSALPSFVQGDAWRNFKAGEQQIIIGKGVADALKV
KQGDWVSIMIPNSNPEHKLMQPKRVRLHVAGILQLSGQLDHSFAMIPLADAQQYLDMGSSVSGIALKMTDVFNANKLVRD
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFV
WYGLLAGLFGSLCGVIIGVVVSLQLTPIIEWIEKLIGHQFLSSDIYFIDFLPSELHWLDVFYVLVTALLLSLLASWYPAR
RASNIDPARVLSGQ
>Mature_413_residues
AMPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVDQPWTNWQEA
LDNVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVNPQQEQRLSALPSFVQGDAWRNFKAGEQQIIIGKGVADALKVK
QGDWVSIMIPNSNPEHKLMQPKRVRLHVAGILQLSGQLDHSFAMIPLADAQQYLDMGSSVSGIALKMTDVFNANKLVRDA
GEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFVW
YGLLAGLFGSLCGVIIGVVVSLQLTPIIEWIEKLIGHQFLSSDIYFIDFLPSELHWLDVFYVLVTALLLSLLASWYPARR
ASNIDPARVLSGQ

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=414, Percent_Identity=99.7584541062802, Blast_Score=833, Evalue=0.0,
Organism=Escherichia coli, GI1787360, Length=415, Percent_Identity=26.7469879518072, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45322; Mature: 45191

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00027 HOMEOBOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRIL
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEE
AVVPHGEIEAVDQPWTNWQEALDNVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVNP
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCEEHHHHCCCCCEEEEEEECCCC
QQEQRLSALPSFVQGDAWRNFKAGEQQIIIGKGVADALKVKQGDWVSIMIPNSNPEHKLM
HHHHHHHHCHHHHCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCEEEEEECCCCCCCCCC
QPKRVRLHVAGILQLSGQLDHSFAMIPLADAQQYLDMGSSVSGIALKMTDVFNANKLVRD
CCHHHEEEHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEHHHHCHHHHHHH
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSG
HHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIAVLRTLGAKDGLIRAIFVWYGLLAGLFGSLCGVIIGVVVSLQLTPIIEWIEKLIGHQF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSSDIYFIDFLPSELHWLDVFYVLVTALLLSLLASWYPARRASNIDPARVLSGQ
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
AMPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRIL
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEE
AVVPHGEIEAVDQPWTNWQEALDNVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVNP
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCEEHHHHCCCCCEEEEEEECCCC
QQEQRLSALPSFVQGDAWRNFKAGEQQIIIGKGVADALKVKQGDWVSIMIPNSNPEHKLM
HHHHHHHHCHHHHCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCEEEEEECCCCCCCCCC
QPKRVRLHVAGILQLSGQLDHSFAMIPLADAQQYLDMGSSVSGIALKMTDVFNANKLVRD
CCHHHEEEHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEHHHHCHHHHHHH
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSG
HHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIAVLRTLGAKDGLIRAIFVWYGLLAGLFGSLCGVIIGVVVSLQLTPIIEWIEKLIGHQF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSSDIYFIDFLPSELHWLDVFYVLVTALLLSLLASWYPARRASNIDPARVLSGQ
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]