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The map label for this gene is ydhC [H]

Identifier: 170680618

GI number: 170680618

Start: 1521737

End: 1522948

Strand: Reverse

Name: ydhC [H]

Synonym: EcSMS35_1537

Alternate gene names: 170680618

Gene position: 1522948-1521737 (Counterclockwise)

Preceding gene: 170683174

Following gene: 170682135

Centisome position: 30.05

GC content: 53.05

Gene sequence:

>1212_bases
ATGCAACCTGGGAAAAGATTTTTAGTCTGGCTGGCAGGTTTGAGCGTACTCGGTTTTCTGGCAACCGATATGTATCTGCC
TGCTTTCGCCGCCATACAGGCCGACCTGCAAACGCCTGCGTCTGCTGTCAGTGCCAGCCTTAGTCTGTTCCTTGCCGGAT
TTGCCGCAGCCCAGCTTCTGTGGGGGCCGCTCTCCGACCGTTATGGTCGTAAACCGGTATTATTCATCGGCCTGACAATT
TTTGCGTTAGGTAGTCTGGGGATGCTGTGGGTAGAAAACGCCGCTACGCTGCTGGTATTGCGTTTTGTACAGGCTGTGGG
TGTCTGCGCCGCGGCGGTTATCTGGCAAGCGTTAGTGACGGATTATTATCCTTCACAGAAAGTTAACCGTATTTTTGCGA
CCATCATGCCGCTGGTGGGTCTATCTCCGGCACTGGCTCCTCTGTTAGGAAGCTGGCTGCTGGTCCATTTTTCCTGGCAG
GCGATTTTCGCCACCCTGTTTGCCATTACCGTGGTGCTGATTCTGCCTATTTTCTGGCTCAAACCCACGACGAAGGCCCG
TAACAATAGTCAGGATGGTCTGACCTTTACCGACCTGCTACGTTCTAAAACCTATCGCGGCAACGTGCTGATATATGCGG
CCTGTTCAGCCAGTTTTTTTGCATGGCTGACCGGCTCACCGTTCATCCTTAGTGAAATGGGTTACAGCCCGGCAGTTATT
GGTTTAAGTTATGTCCCGCAAACTATCGCGTTTCTGATTGGTGGTTATGGCTGTCGCGCCGCACTGCAGAAATGGCAAGG
CAAGCAGTTATTACCGTGGTTGCTGGTACTGTTTGCTGTCAGCGTCATTGCGACCTGGGCTGCGGGCTTCATTAGCCATG
TGTCGCTAGTCGAAATCCTGATCCCATTCTGTGTGATGGCGATTGCCAACGGTGCGATCTACCCGATTGTTGTCGCTCAG
GCGCTGCGTCCCTTCCCACATGCAACTGGTCGCGCCGCAGCGTTGCAGAACACTCTGCAACTGGGTCTGTGCTTCCTCGC
AAGTCTGGTAGTTTCCTGGCTTATCAGTATCAGCACGCCATTGCTCACCACCACCAGCGTGATGTTATCAACAGTAGTGC
TGGTCGCTCTGGGTTACATGATGCAACGTTGTGAAGAAGTTGGCTGCCAGAATCATGGCAATGCCGAAGTCGCTCATAGC
GAATCACACTGA

Upstream 100 bases:

>100_bases
AAATTTTTGAAACCAGTCATCAAATATTACCGTTTCACAACACTAATTTCACTCCCTACACTTTGCGGCGGTGTTTAATT
GAGAGATTTAGAGAATATAC

Downstream 100 bases:

>100_bases
TCTATATCGATATACTTATACTTAGGCTGCTAACAAAATTTTGTTGTATGATTGAAATTAGCGGCCTATACTAATTTCGA
GTTGTTAAAGCTACGATAAA

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLFIGLTI
FALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLLGSWLLVHFSWQ
AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI
GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS
ESH

Sequences:

>Translated_403_residues
MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLFIGLTI
FALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLLGSWLLVHFSWQ
AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI
GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS
ESH
>Mature_403_residues
MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLFIGLTI
FALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLLGSWLLVHFSWQ
AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI
GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS
ESH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=403, Percent_Identity=99.5037220843672, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1788509, Length=337, Percent_Identity=28.7833827893175, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790146, Length=242, Percent_Identity=29.3388429752066, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082312, Length=340, Percent_Identity=25, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790794, Length=223, Percent_Identity=27.3542600896861, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787065, Length=217, Percent_Identity=25.3456221198157, Blast_Score=82, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319657, Length=167, Percent_Identity=26.3473053892216, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43432; Mature: 43432

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]