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The map label for this gene is manR [H]

Identifier: 170680552

GI number: 170680552

Start: 4075489

End: 4077042

Strand: Reverse

Name: manR [H]

Synonym: EcSMS35_3997

Alternate gene names: 170680552

Gene position: 4077042-4075489 (Counterclockwise)

Preceding gene: 170680791

Following gene: 170683316

Centisome position: 80.44

GC content: 41.38

Gene sequence:

>1554_bases
ATGCAAATGATTACCTCGCGACAAAACAGATTATTACGATTCCTTCTACCACGAAGGGAATATACGACTATTGTTACAAT
TGCCGGCTATTTAAATGTTTCGGAAAAAACCATTCAACGTGATTTACGTTTACTTGAGCAATGGCTGGGGCAATGGAGAA
TAAATGTTGAGAAGCGTGCTGGCGCGGGTGTGATGTTAAGCGCGGAGAATATTGCTGATTTGCTGCATCTTGATCATTTG
TTGGGAGCAGAATGTGAAGAGATTGATGGTGTAATGAATAATGCCAGGCGCGTTAAAATAGCGTCGCAGTTATTAAGTGA
AACACCGAATGAAACGTCGATCAGTAAATTGTCAGAACGCTACTTTATCAGCGGAGCCTCTATTGTTAATGACCTGAGAG
TAATTGAGTCCTGGCTTGCGCCGTTGGGGTTATCATTGATCCGCAGCCCAAGTGGTACGCATATTGAAGGTAGTGAAGGG
CAAGTCCGACAGGCAATGGCATTACTGATTAACGGCATTATTAACCATAATGAGCCGCAAGGTGTCGTGTATTCACGTCT
GGATCCCGGAAGCTATAAAGCATTAGTCCATTATTTTGGAGAGGAAGAAGTGTTATTTGTCCAGTCATTGTTACTGGATA
TGGAAAATGAATTAAGTTGGTCTTTGGGAGAACCTTATTACGTTAACATTTTTACTCACATCCTTATTATGATGTATCGC
AACACGCACGGGAATGCGTTATCAAGAGAAGAAGATCAAACCAGGCAATATGATGAAAATATCTTTAATGTTGCCAGTCA
GATGATTCATAAGATAGAACAACGAATTGCACATACATTGCCCGATGATGAAGTCTGGTTTATTTATCAATATATCATTT
CATCAGGTGTGGCGATTGATGGACAAAAAGATGTGAGCATTATTTCACATATGCAGGCCAGCAATGAAGCGCGTCTGATT
ACCTGGCGTTTAATTACGGTATTCAGTGACATCGTGGACTGCGATTTTAGTGAAGACAGCGCATTATATGATGGCTTAAT
GGTGCATATTAAACCGCTGATTAACCGACTAAATTATCGTATTCATATCCGTAATCCATTGTTGGAAGATATTAAAGCAG
AACTAGCGGATGTCTGGCGGTTGACGCAATATGTGGTGAATCAGGTATTTAAAACCTGGGGTGAGAATGCAGTGAGCGAG
GATGAAGTGGGTTACCTGACCGTTCATTTTCAGGCTGCGATGGAGCGGCAAATTGCCCGTAAACGTGTATTACTGGTCTG
TTCAACCGGAATCGGAACTTCGCATCTACTGAAAAGCCGTATTCTGCGAGCATTTCCTGAATGGACGATTGTTGATGTTA
TTTCAGCAGCGAATTTATCACAGGTTTTGCCTGACAATATCGAACTGATTATTTCGACAATTAATTTGCCTACAGTCACT
ATGCCGGTCGCTTATGTTACCGCTTTTTTTAATGATGCCGATATTAAGCGGGTCACTGAAATGGTGATTACGGAAAAATT
ACATCATGCGACGTCTCGGGTCGTTGAAATTTAA

Upstream 100 bases:

>100_bases
TTAGTATTGTTGTGAAATTATTCTGCTTTATATTTACCCTCAGAGATGGCAACTGAAGCTCTTCCATATGGGGCTTCTTA
ATCTGTGATAAGGGTAAAAA

Downstream 100 bases:

>100_bases
TGTCAGAATTTTATGAGGTATGACGAATGGACATAACAAAAATCCTGAATACGAATCGCGTTATTTTAGATATGCAAGCG
ACGAATAAAGCGGAGGCGAT

Product: putative PTS regulatory protein

Products: NA

Alternate protein names: Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MQMITSRQNRLLRFLLPRREYTTIVTIAGYLNVSEKTIQRDLRLLEQWLGQWRINVEKRAGAGVMLSAENIADLLHLDHL
LGAECEEIDGVMNNARRVKIASQLLSETPNETSISKLSERYFISGASIVNDLRVIESWLAPLGLSLIRSPSGTHIEGSEG
QVRQAMALLINGIINHNEPQGVVYSRLDPGSYKALVHYFGEEEVLFVQSLLLDMENELSWSLGEPYYVNIFTHILIMMYR
NTHGNALSREEDQTRQYDENIFNVASQMIHKIEQRIAHTLPDDEVWFIYQYIISSGVAIDGQKDVSIISHMQASNEARLI
TWRLITVFSDIVDCDFSEDSALYDGLMVHIKPLINRLNYRIHIRNPLLEDIKAELADVWRLTQYVVNQVFKTWGENAVSE
DEVGYLTVHFQAAMERQIARKRVLLVCSTGIGTSHLLKSRILRAFPEWTIVDVISAANLSQVLPDNIELIISTINLPTVT
MPVAYVTAFFNDADIKRVTEMVITEKLHHATSRVVEI

Sequences:

>Translated_517_residues
MQMITSRQNRLLRFLLPRREYTTIVTIAGYLNVSEKTIQRDLRLLEQWLGQWRINVEKRAGAGVMLSAENIADLLHLDHL
LGAECEEIDGVMNNARRVKIASQLLSETPNETSISKLSERYFISGASIVNDLRVIESWLAPLGLSLIRSPSGTHIEGSEG
QVRQAMALLINGIINHNEPQGVVYSRLDPGSYKALVHYFGEEEVLFVQSLLLDMENELSWSLGEPYYVNIFTHILIMMYR
NTHGNALSREEDQTRQYDENIFNVASQMIHKIEQRIAHTLPDDEVWFIYQYIISSGVAIDGQKDVSIISHMQASNEARLI
TWRLITVFSDIVDCDFSEDSALYDGLMVHIKPLINRLNYRIHIRNPLLEDIKAELADVWRLTQYVVNQVFKTWGENAVSE
DEVGYLTVHFQAAMERQIARKRVLLVCSTGIGTSHLLKSRILRAFPEWTIVDVISAANLSQVLPDNIELIISTINLPTVT
MPVAYVTAFFNDADIKRVTEMVITEKLHHATSRVVEI
>Mature_517_residues
MQMITSRQNRLLRFLLPRREYTTIVTIAGYLNVSEKTIQRDLRLLEQWLGQWRINVEKRAGAGVMLSAENIADLLHLDHL
LGAECEEIDGVMNNARRVKIASQLLSETPNETSISKLSERYFISGASIVNDLRVIESWLAPLGLSLIRSPSGTHIEGSEG
QVRQAMALLINGIINHNEPQGVVYSRLDPGSYKALVHYFGEEEVLFVQSLLLDMENELSWSLGEPYYVNIFTHILIMMYR
NTHGNALSREEDQTRQYDENIFNVASQMIHKIEQRIAHTLPDDEVWFIYQYIISSGVAIDGQKDVSIISHMQASNEARLI
TWRLITVFSDIVDCDFSEDSALYDGLMVHIKPLINRLNYRIHIRNPLLEDIKAELADVWRLTQYVVNQVFKTWGENAVSE
DEVGYLTVHFQAAMERQIARKRVLLVCSTGIGTSHLLKSRILRAFPEWTIVDVISAANLSQVLPDNIELIISTINLPTVT
MPVAYVTAFFNDADIKRVTEMVITEKLHHATSRVVEI

Specific function: May regulate the expression of the mannose operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF00359 PTS_EIIA_2 [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 58916; Mature: 58916

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMITSRQNRLLRFLLPRREYTTIVTIAGYLNVSEKTIQRDLRLLEQWLGQWRINVEKRA
CCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHHHHCEEEEEECCC
GAGVMLSAENIADLLHLDHLLGAECEEIDGVMNNARRVKIASQLLSETPNETSISKLSER
CCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHH
YFISGASIVNDLRVIESWLAPLGLSLIRSPSGTHIEGSEGQVRQAMALLINGIINHNEPQ
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCC
GVVYSRLDPGSYKALVHYFGEEEVLFVQSLLLDMENELSWSLGEPYYVNIFTHILIMMYR
CEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHH
NTHGNALSREEDQTRQYDENIFNVASQMIHKIEQRIAHTLPDDEVWFIYQYIISSGVAID
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEC
GQKDVSIISHMQASNEARLITWRLITVFSDIVDCDFSEDSALYDGLMVHIKPLINRLNYR
CCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEE
IHIRNPLLEDIKAELADVWRLTQYVVNQVFKTWGENAVSEDEVGYLTVHFQAAMERQIAR
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHH
KRVLLVCSTGIGTSHLLKSRILRAFPEWTIVDVISAANLSQVLPDNIELIISTINLPTVT
HHEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHCCCCCEEEEEECCCCCHH
MPVAYVTAFFNDADIKRVTEMVITEKLHHATSRVVEI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQMITSRQNRLLRFLLPRREYTTIVTIAGYLNVSEKTIQRDLRLLEQWLGQWRINVEKRA
CCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHHHHCEEEEEECCC
GAGVMLSAENIADLLHLDHLLGAECEEIDGVMNNARRVKIASQLLSETPNETSISKLSER
CCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHH
YFISGASIVNDLRVIESWLAPLGLSLIRSPSGTHIEGSEGQVRQAMALLINGIINHNEPQ
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCC
GVVYSRLDPGSYKALVHYFGEEEVLFVQSLLLDMENELSWSLGEPYYVNIFTHILIMMYR
CEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHH
NTHGNALSREEDQTRQYDENIFNVASQMIHKIEQRIAHTLPDDEVWFIYQYIISSGVAID
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEC
GQKDVSIISHMQASNEARLITWRLITVFSDIVDCDFSEDSALYDGLMVHIKPLINRLNYR
CCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEE
IHIRNPLLEDIKAELADVWRLTQYVVNQVFKTWGENAVSEDEVGYLTVHFQAAMERQIAR
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHH
KRVLLVCSTGIGTSHLLKSRILRAFPEWTIVDVISAANLSQVLPDNIELIISTINLPTVT
HHEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHCCCCCEEEEEECCCCCHH
MPVAYVTAFFNDADIKRVTEMVITEKLHHATSRVVEI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]