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The map label for this gene is coaBC [H]

Identifier: 229597228

GI number: 229597228

Start: 4587287

End: 4588501

Strand: Direct

Name: coaBC [H]

Synonym: YPK_4156

Alternate gene names: 229597228

Gene position: 4587287-4588501 (Clockwise)

Preceding gene: 170026358

Following gene: 170026364

Centisome position: 97.82

GC content: 48.15

Gene sequence:

>1215_bases
ATGACGGGACTTTCCGGCAAGCATATTGTGCTCGGGATAAGCGGAGGCATTGCCGCATATAAATCTCCTGAGCTCGTACG
CCGTTTGCGCGACAAAGGTGCAGATGTGCGTGTAGTGATGACCCACGCCGCTAAAGCGTTCATAGCACCACTCACGCTAC
AGGCAGTCTCGGGCTATCCCGTTTCTGATGATTTGCTCGATCCTGCGGCAGAAGCCGCTATGGGGCATATTGAACTGGGC
AAATGGGCTGACTTAGTCATTATTGCCCCCGCTACGGCGGATTTACTGGCCAGAATGGCAGCCGGAATGGCCAATGACCT
ACTGACCACCGTTTGTCTGGCAACCGCTGCGCCTATTGCCGCAGTACCGGCCATGAATCAGCAAATGTACCGTGCGCCAG
CCACACAGGAGAATTTACAAACCTTGTCTAAATGGGGTGTCTTGCTGTGGGGGCCAGATAGCGGTAGCCAGGCTTGTGGC
GATATCGGCCCTGGTAGAATGTTAGACCCACAAGAAATCGTGGCTTTAGCGTACAATCATTTCTCTGCAAAGCAAGATCT
GCAACATTTGAGTGTCATGATTACCGCCGGGCCAACACGCGAACCACTTGATCCTGTACGCTTTATCAGCAATCAAAGTT
CGGGCAAGATGGGCTTCGCGATTGCCCAAGCATTGGCTGCAAGAGGATCTAACGTCACGCTAATCGCTGGCCCCGTGAAT
TTATCGACACCTGAAGGTGTAAAACGTATTGATGTGATTACAGCTCTTGAGATGCAGCAGGCTGTTCAAAAAATAGCACA
GCAGCAGAACATTTTTATTTCTTGTGCCGCAGTAGCGGATTACCGCGCGGAACACGTTTCTGACGAGAAAATAAAAAAAC
AAGGTGACGAAATCACACTTAAGTTGGTGAAAAATCCCGATATTGTTGCTGGTGTGGCTTCAATGGCTAAAAATCGTCCA
TTTGTTGTTGGATTTGCGGCTGAAACCCAGAATGTGGAAGAATACGCGCGACAAAAGTTGGCGCGAAAAAATTTAGATCT
GATTTGCGCTAATGATGTATCACTCGCAGAGCATGGTTTTAACAGTGATACCAATGCCTTGCACCTTTTTTGGTCGACTG
GAGAGAAACATTTACCACTCAGTGATAAATATCTTCTCAGTCAACGTTTAATAGACGAGATTGTCAGCCGTTATGATGAA
AAAAATCGACATTAA

Upstream 100 bases:

>100_bases
AATTTTACGATTGGTCGCTTCAGAGAGTGCCCTGATAGCTAATCTGTTCAATGGTTATGCTAAAATATCGCCTCTTACAG
CTTTCATTCGGACAATCATG

Downstream 100 bases:

>100_bases
AATTCTGGACCCACGTGTTGGCAACGAATTTCCATTACCCACGTATGCCACCGAAGGTTCTGCCGGGCTGGATTTACGTG
CTTGTTTAGATCACGCAGTA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTGLSGKHIVLGISGGIAAYKSPELVRRLRDKGADVRVVMTHAAKAFIAPLTLQAVSGYPVSDDLLDPAAEAAMGHIELG
KWADLVIIAPATADLLARMAAGMANDLLTTVCLATAAPIAAVPAMNQQMYRAPATQENLQTLSKWGVLLWGPDSGSQACG
DIGPGRMLDPQEIVALAYNHFSAKQDLQHLSVMITAGPTREPLDPVRFISNQSSGKMGFAIAQALAARGSNVTLIAGPVN
LSTPEGVKRIDVITALEMQQAVQKIAQQQNIFISCAAVADYRAEHVSDEKIKKQGDEITLKLVKNPDIVAGVASMAKNRP
FVVGFAAETQNVEEYARQKLARKNLDLICANDVSLAEHGFNSDTNALHLFWSTGEKHLPLSDKYLLSQRLIDEIVSRYDE
KNRH

Sequences:

>Translated_404_residues
MTGLSGKHIVLGISGGIAAYKSPELVRRLRDKGADVRVVMTHAAKAFIAPLTLQAVSGYPVSDDLLDPAAEAAMGHIELG
KWADLVIIAPATADLLARMAAGMANDLLTTVCLATAAPIAAVPAMNQQMYRAPATQENLQTLSKWGVLLWGPDSGSQACG
DIGPGRMLDPQEIVALAYNHFSAKQDLQHLSVMITAGPTREPLDPVRFISNQSSGKMGFAIAQALAARGSNVTLIAGPVN
LSTPEGVKRIDVITALEMQQAVQKIAQQQNIFISCAAVADYRAEHVSDEKIKKQGDEITLKLVKNPDIVAGVASMAKNRP
FVVGFAAETQNVEEYARQKLARKNLDLICANDVSLAEHGFNSDTNALHLFWSTGEKHLPLSDKYLLSQRLIDEIVSRYDE
KNRH
>Mature_403_residues
TGLSGKHIVLGISGGIAAYKSPELVRRLRDKGADVRVVMTHAAKAFIAPLTLQAVSGYPVSDDLLDPAAEAAMGHIELGK
WADLVIIAPATADLLARMAAGMANDLLTTVCLATAAPIAAVPAMNQQMYRAPATQENLQTLSKWGVLLWGPDSGSQACGD
IGPGRMLDPQEIVALAYNHFSAKQDLQHLSVMITAGPTREPLDPVRFISNQSSGKMGFAIAQALAARGSNVTLIAGPVNL
STPEGVKRIDVITALEMQQAVQKIAQQQNIFISCAAVADYRAEHVSDEKIKKQGDEITLKLVKNPDIVAGVASMAKNRPF
VVGFAAETQNVEEYARQKLARKNLDLICANDVSLAEHGFNSDTNALHLFWSTGEKHLPLSDKYLLSQRLIDEIVSRYDEK
NRH

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=171, Percent_Identity=34.5029239766082, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=75.7425742574257, Blast_Score=619, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17560194, Length=189, Percent_Identity=32.2751322751323, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=186, Percent_Identity=29.5698924731183, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322925, Length=104, Percent_Identity=36.5384615384615, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=31.9148936170213, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43476; Mature: 43345

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLSGKHIVLGISGGIAAYKSPELVRRLRDKGADVRVVMTHAAKAFIAPLTLQAVSGYP
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCC
VSDDLLDPAAEAAMGHIELGKWADLVIIAPATADLLARMAAGMANDLLTTVCLATAAPIA
CCHHHCCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AVPAMNQQMYRAPATQENLQTLSKWGVLLWGPDSGSQACGDIGPGRMLDPQEIVALAYNH
HCCCCCHHHHCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FSAKQDLQHLSVMITAGPTREPLDPVRFISNQSSGKMGFAIAQALAARGSNVTLIAGPVN
HHHHHHHHHEEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
LSTPEGVKRIDVITALEMQQAVQKIAQQQNIFISCAAVADYRAEHVSDEKIKKQGDEITL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHCCHHHHHHCCCEEEE
KLVKNPDIVAGVASMAKNRPFVVGFAAETQNVEEYARQKLARKNLDLICANDVSLAEHGF
EEECCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCHHHHCCC
NSDTNALHLFWSTGEKHLPLSDKYLLSQRLIDEIVSRYDEKNRH
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGLSGKHIVLGISGGIAAYKSPELVRRLRDKGADVRVVMTHAAKAFIAPLTLQAVSGYP
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCC
VSDDLLDPAAEAAMGHIELGKWADLVIIAPATADLLARMAAGMANDLLTTVCLATAAPIA
CCHHHCCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AVPAMNQQMYRAPATQENLQTLSKWGVLLWGPDSGSQACGDIGPGRMLDPQEIVALAYNH
HCCCCCHHHHCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FSAKQDLQHLSVMITAGPTREPLDPVRFISNQSSGKMGFAIAQALAARGSNVTLIAGPVN
HHHHHHHHHEEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
LSTPEGVKRIDVITALEMQQAVQKIAQQQNIFISCAAVADYRAEHVSDEKIKKQGDEITL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHCCHHHHHHCCCEEEE
KLVKNPDIVAGVASMAKNRPFVVGFAAETQNVEEYARQKLARKNLDLICANDVSLAEHGF
EEECCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCHHHHCCC
NSDTNALHLFWSTGEKHLPLSDKYLLSQRLIDEIVSRYDEKNRH
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]