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The map label for this gene is hemN [H]

Identifier: 170026399

GI number: 170026399

Start: 4625786

End: 4627159

Strand: Reverse

Name: hemN [H]

Synonym: YPK_4192

Alternate gene names: 170026399

Gene position: 4627159-4625786 (Counterclockwise)

Preceding gene: 170026400

Following gene: 170026395

Centisome position: 98.67

GC content: 47.6

Gene sequence:

>1374_bases
ATGTCTGAGCACGCTATAGTTTGGGATCTATCCCTGATTCAAAAATATAATTATTCAGGGCCGCGTTATACCTCGTATCC
AACGGCTCTTGAGTTTAGTGAAGATTACAATGAGTCTGCTTTCCAGCAGGCGGTGAAACGTTATCCGCAACGGCCATTGT
CGCTGTATGTGCATATTCCGTTTTGCCACAAACTTTGCTACTTCTGTGGCTGCAATAAACTGGTGACGCGTCAGCAACAT
AAAGCTGATGAATATCTGGTGGTGTTGGAAAAAGAGATCCGCCAGCGGGCTGCCTTATTTACCGGGCGTCAGGTCAGCCA
GATGCACTGGGGGGGGGGTACGCCAACCTATCTGAATAAAACGCAAATCAGCCATTTAATGACGGTGCTGCGTGAACACT
TTGATTTTCTGCCCGATGCGGAGCAGTCAATCGAAGTTGACCCCCGTGAAATTGAATTAGATGTGCTTGATCACCTGCGT
GCTGAAGGGTTTAATCGCCTGAGCATGGGGGTGCAGGATTTCAATAAAGAGGTGCAGCGGCTGGTTAACCGCGAGCAAGA
TGAAGATTTTATCTTCGCTTTAATTGCCCGAGCTAAAGCGCTTGGATTTAACTCAACCAATATTGATTTGATTTATGGCT
TGCCCAAGCAGACACCAGAAAGTTTTGCTTTCACCTTAAAACGGGTTGCTGAGCTGAACCCAGATCGCTTAAGCGTGTTT
AATTACGCCCATCTGCCAAGCCTGTTTGCCGCCCAACGTAAAATCAAAGACGCTGATCTGCCAACGGCGGAGCAACGGTT
GGATATTTTGCAGCACACCATCCGTTTCTTAACGGAGTCTGGCTATCAATTCATTGGGATGGATCATTTTGCGCGTCCGG
ATGATGAACTGGCAATTGCTCAGCAGGAAGGAACATTACACCGCAACTTTCAAGGGTATACCACGCAGGGTGAGAGCGAT
CTCCTTGGGTTGGGGGTTTCTGCTATCAGCATGTTAGGTGACAGCTACGCTCAGAATGAAAAAGATCTGGAAACATATTA
CGCCTGTGTAGAGCAACGGGGTAATGCGTTGTGGCGCGGCCTGACTATGACCGAAGACGATTGTTTACGCCGAGATGTGA
TTAAAACGCTGATTTGTCATTTCCAACTCAGTTACCAGCCGATTGAGCAGCGTTATGGTATTCGGTTTGCCGATTATTTT
GCCGAAGATTTTGAGCTGCTTGCACCTTTTGAACAGGATGGGCTGGTGGAGCGAAATGAAACAGGGCTTCGCGTGACCCC
CCGTGGGCGCTTACTCATTCGTAATATTTGTATGTGTTTCGATATCTATTTACGTAAACAGGCGCGCAAGCAGCAATTCT
CACGTGTAATCTGA

Upstream 100 bases:

>100_bases
CGCAACGCAAATCACGGTTGCGCAGTGCTACTGCGGTCAGACAACAAAAACATCTGCCCTCTAACCGACCCGGTAGGCGA
AAATATCGGAAGGAGTGAAC

Downstream 100 bases:

>100_bases
CGATATCACCCTCAGTGCGGTTATCGCTCTTGAGGGTGACCATCTGGCGGGAACTACTCCATCCCCAACTCTTTCAACTT
CCGCGTTAATGTATTACGGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSEHAIVWDLSLIQKYNYSGPRYTSYPTALEFSEDYNESAFQQAVKRYPQRPLSLYVHIPFCHKLCYFCGCNKLVTRQQH
KADEYLVVLEKEIRQRAALFTGRQVSQMHWGGGTPTYLNKTQISHLMTVLREHFDFLPDAEQSIEVDPREIELDVLDHLR
AEGFNRLSMGVQDFNKEVQRLVNREQDEDFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAFTLKRVAELNPDRLSVF
NYAHLPSLFAAQRKIKDADLPTAEQRLDILQHTIRFLTESGYQFIGMDHFARPDDELAIAQQEGTLHRNFQGYTTQGESD
LLGLGVSAISMLGDSYAQNEKDLETYYACVEQRGNALWRGLTMTEDDCLRRDVIKTLICHFQLSYQPIEQRYGIRFADYF
AEDFELLAPFEQDGLVERNETGLRVTPRGRLLIRNICMCFDIYLRKQARKQQFSRVI

Sequences:

>Translated_457_residues
MSEHAIVWDLSLIQKYNYSGPRYTSYPTALEFSEDYNESAFQQAVKRYPQRPLSLYVHIPFCHKLCYFCGCNKLVTRQQH
KADEYLVVLEKEIRQRAALFTGRQVSQMHWGGGTPTYLNKTQISHLMTVLREHFDFLPDAEQSIEVDPREIELDVLDHLR
AEGFNRLSMGVQDFNKEVQRLVNREQDEDFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAFTLKRVAELNPDRLSVF
NYAHLPSLFAAQRKIKDADLPTAEQRLDILQHTIRFLTESGYQFIGMDHFARPDDELAIAQQEGTLHRNFQGYTTQGESD
LLGLGVSAISMLGDSYAQNEKDLETYYACVEQRGNALWRGLTMTEDDCLRRDVIKTLICHFQLSYQPIEQRYGIRFADYF
AEDFELLAPFEQDGLVERNETGLRVTPRGRLLIRNICMCFDIYLRKQARKQQFSRVI
>Mature_456_residues
SEHAIVWDLSLIQKYNYSGPRYTSYPTALEFSEDYNESAFQQAVKRYPQRPLSLYVHIPFCHKLCYFCGCNKLVTRQQHK
ADEYLVVLEKEIRQRAALFTGRQVSQMHWGGGTPTYLNKTQISHLMTVLREHFDFLPDAEQSIEVDPREIELDVLDHLRA
EGFNRLSMGVQDFNKEVQRLVNREQDEDFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAFTLKRVAELNPDRLSVFN
YAHLPSLFAAQRKIKDADLPTAEQRLDILQHTIRFLTESGYQFIGMDHFARPDDELAIAQQEGTLHRNFQGYTTQGESDL
LGLGVSAISMLGDSYAQNEKDLETYYACVEQRGNALWRGLTMTEDDCLRRDVIKTLICHFQLSYQPIEQRYGIRFADYFA
EDFELLAPFEQDGLVERNETGLRVTPRGRLLIRNICMCFDIYLRKQARKQQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=247, Percent_Identity=26.7206477732794, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI87082341, Length=457, Percent_Identity=78.5557986870897, Blast_Score=769, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=244, Percent_Identity=32.7868852459016, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 53055; Mature: 52924

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHAIVWDLSLIQKYNYSGPRYTSYPTALEFSEDYNESAFQQAVKRYPQRPLSLYVHIP
CCCCEEEEEHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCEEEEEECH
FCHKLCYFCGCNKLVTRQQHKADEYLVVLEKEIRQRAALFTGRQVSQMHWGGGTPTYLNK
HHHHHHHHHCCCHHHHHHHHCCCHHEEHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCH
TQISHLMTVLREHFDFLPDAEQSIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVNREQDEDFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAFTLKRVAELNPDRLSVF
HHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHH
NYAHLPSLFAAQRKIKDADLPTAEQRLDILQHTIRFLTESGYQFIGMDHFARPDDELAIA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEE
QQEGTLHRNFQGYTTQGESDLLGLGVSAISMLGDSYAQNEKDLETYYACVEQRGNALWRG
CCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHCCC
LTMTEDDCLRRDVIKTLICHFQLSYQPIEQRYGIRFADYFAEDFELLAPFEQDGLVERNE
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
TGLRVTPRGRLLIRNICMCFDIYLRKQARKQQFSRVI
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEHAIVWDLSLIQKYNYSGPRYTSYPTALEFSEDYNESAFQQAVKRYPQRPLSLYVHIP
CCCEEEEEHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCEEEEEECH
FCHKLCYFCGCNKLVTRQQHKADEYLVVLEKEIRQRAALFTGRQVSQMHWGGGTPTYLNK
HHHHHHHHHCCCHHHHHHHHCCCHHEEHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCH
TQISHLMTVLREHFDFLPDAEQSIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVNREQDEDFIFALIARAKALGFNSTNIDLIYGLPKQTPESFAFTLKRVAELNPDRLSVF
HHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEHH
NYAHLPSLFAAQRKIKDADLPTAEQRLDILQHTIRFLTESGYQFIGMDHFARPDDELAIA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEE
QQEGTLHRNFQGYTTQGESDLLGLGVSAISMLGDSYAQNEKDLETYYACVEQRGNALWRG
CCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHCCC
LTMTEDDCLRRDVIKTLICHFQLSYQPIEQRYGIRFADYFAEDFELLAPFEQDGLVERNE
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
TGLRVTPRGRLLIRNICMCFDIYLRKQARKQQFSRVI
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]