Click here to switch to the map view.

The map label for this gene is wecA

Identifier: 170026243

GI number: 170026243

Start: 4448225

End: 4449307

Strand: Reverse

Name: wecA

Synonym: YPK_4033

Alternate gene names: 170026243

Gene position: 4449307-4448225 (Counterclockwise)

Preceding gene: 170026244

Following gene: 170026242

Centisome position: 94.88

GC content: 46.91

Gene sequence:

>1083_bases
ATGAGTACTGAATTAATTTATATCTTTCTGTTTTCTATGGCATTTCTATTTGTTGCTCGCAAAGTTGCCATAAAAATTGG
ACTTGTCGATAAACCCAACTACCGTAAGCGCCATCAAGGATTAATCCCTCTGGTGGGGGGAATATCGGTATTCGCGGGGG
TCTGTTTTGCTTTTCTGATTACTAATCAGCAAATTCCCCATTTTCGTTTATATCTTGCATGTGCCGGGTTATTGGTCTTC
GTTGGTGCTTTAGATGATCGTTTTGATATCAGCGTAAAAATTCGCGCTTTTGTTCAAGCACTGGTCGGCATCGCGATGAT
GGCAGTCGCGGGGCTATATTTACGTAGTCTGGGGCATGCCTTCGGTCCATGGGAAATGGTATTAGGGCCATTTGGTTATG
TGGTCACCCTGTTTGCGGTTTGGGCGGCCATCAATGCGTTCAACATGGTTGATGGAATAGATGGCTTGCTGGGTGGCCTA
TCCTGTGTTTCCTTCGGGGCCATGGGGATTTTGTTGTACCAAAGTGGGCAGATGTCATTGGCGTTATGGTGTTTCGCCAT
GATAGCCACCATTATTCCCTATATCTTACTGAATCTCGGGTTACTGGGTCGCCGCTATAAAGTCTTCATGGGCGATGCTG
GCAGTACTTTGATTGGTTTCACCGCGATCTGGATCCTGTTACAGGCGACTCAGGGTAATGCTCATCCGATCAACCCTGTG
ACGGCACTATGGATTATCGCCATTCCGTTGATGGACATGATTGCCATCATGTATCGTCGTTTACGCAAAGGCATGAGTCC
TTTCTCTCCAGATCGCCAACATATTCATCATTTAATCATGCGGGCCGGTTTTACCTCCCGGCAAGCTTTTGTCCTCATCA
CACTGGCTGCCGCGTTGTTAGCCATGATTGGTGTTATCGGCGAACGGCTGACATTTATACCCGAATGGGTCATGTTGGCA
TTGTTCTTGCTTGCATTTCTATTGTATGGCTACTGCATTAAACGGGCATGGCGGGTGGCGCGTTTTATCAAACGTTTCAA
GCGTCGGATGCGGCGGGCATCGAAAAATAAGCATGAATCTTAA

Upstream 100 bases:

>100_bases
GATATAACTGAAAGCGTGTTGGGGGCATAGCAAGTGCTAATCTACATGCTAAGCTGTTGTATCTTTTTGCAGAGAGCGGT
TAAACGTGAACCTACTCACT

Downstream 100 bases:

>100_bases
CCAGAGGCTTTTAGGCAGTGATGAAACCAGAATCTATGTCGACTGATAAAACAGGGTCTACCAATAATGAACCGTCTGTG
GATAACGAATTAGATATCCG

Product: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSTELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVCFAFLITNQQIPHFRLYLACAGLLVF
VGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLRSLGHAFGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDGLLGGL
SCVSFGAMGILLYQSGQMSLALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAHPINPV
TALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLAMIGVIGERLTFIPEWVMLA
LFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASKNKHES

Sequences:

>Translated_360_residues
MSTELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVCFAFLITNQQIPHFRLYLACAGLLVF
VGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLRSLGHAFGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDGLLGGL
SCVSFGAMGILLYQSGQMSLALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAHPINPV
TALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLAMIGVIGERLTFIPEWVMLA
LFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASKNKHES
>Mature_359_residues
STELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVCFAFLITNQQIPHFRLYLACAGLLVFV
GALDDRFDISVKIRAFVQALVGIAMMAVAGLYLRSLGHAFGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDGLLGGLS
CVSFGAMGILLYQSGQMSLALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAHPINPVT
ALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLAMIGVIGERLTFIPEWVMLAL
FLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASKNKHES

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily

Homologues:

Organism=Escherichia coli, GI1790218, Length=344, Percent_Identity=80.8139534883721, Blast_Score=526, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WECA_YERPE (Q8ZAE1)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0471
- RefSeq:   NP_667700.1
- RefSeq:   NP_994470.1
- RefSeq:   YP_002348744.1
- ProteinModelPortal:   Q8ZAE1
- IntAct:   Q8ZAE1
- GeneID:   1145309
- GeneID:   1176705
- GeneID:   2766489
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3866
- KEGG:   ypk:y0362
- KEGG:   ypm:YP_3179
- HOGENOM:   HBG536396
- OMA:   LWIISIT
- ProtClustDB:   PRK15119
- BioCyc:   YPES187410:Y0362-MONOMER
- BioCyc:   YPES214092:YPO3866-MONOMER
- InterPro:   IPR012750
- InterPro:   IPR000715
- PANTHER:   PTHR22926
- TIGRFAMs:   TIGR02380

Pfam domain/function: PF00953 Glycos_transf_4

EC number: 2.7.8.- [C]

Molecular weight: Translated: 40194; Mature: 40063

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1b3b4220)-; HASH(0x1b9e9bc8)-; HASH(0x1b973c1c)-; HASH(0x1ba05210)-; HASH(0x1b6b0f3c)-; HASH(0x1b73c2fc)-; HASH(0x1ba33e68)-; HASH(0x1b98b13c)-; HASH(0x1bb37a04)-; HASH(0x1bb15298)-; HASH(0x1b9b9b14)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVCFAFLI
CCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
TNQQIPHFRLYLACAGLLVFVGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLRSLGHA
HCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDGLLGGLSCVSFGAMGILLYQSGQMSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHH
ALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAHPINPV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
TALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AMIGVIGERLTFIPEWVMLALFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASKNKHES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure 
STELIYIFLFSMAFLFVARKVAIKIGLVDKPNYRKRHQGLIPLVGGISVFAGVCFAFLI
CCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
TNQQIPHFRLYLACAGLLVFVGALDDRFDISVKIRAFVQALVGIAMMAVAGLYLRSLGHA
HCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGPWEMVLGPFGYVVTLFAVWAAINAFNMVDGIDGLLGGLSCVSFGAMGILLYQSGQMSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHH
ALWCFAMIATIIPYILLNLGLLGRRYKVFMGDAGSTLIGFTAIWILLQATQGNAHPINPV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
TALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AMIGVIGERLTFIPEWVMLALFLLAFLLYGYCIKRAWRVARFIKRFKRRMRRASKNKHES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430