Click here to switch to the map view.

The map label for this gene is uvrD [H]

Identifier: 170026218

GI number: 170026218

Start: 4418757

End: 4420919

Strand: Reverse

Name: uvrD [H]

Synonym: YPK_4007

Alternate gene names: 170026218

Gene position: 4420919-4418757 (Counterclockwise)

Preceding gene: 170026219

Following gene: 170026216

Centisome position: 94.27

GC content: 54.42

Gene sequence:

>2163_bases
ATGGACGTTTCTGATCTGCTCGACAGCCTGAATGAAAAACAACGTGACGCCGTGGCCGCGCCGCGCGGCAACTTGTTGGT
ACTGGCCGGTGCAGGCAGTGGCAAAACGCGGGTGCTGGTTCACCGTATCGCCTGGCTGTTGTCGGTAGAGAATGCCTCGC
CGTATTCGATTATCTCGGTAACCTTTACCAATAAAGCGGCGGCTGAAATGCGCCACCGTATTGAACATCTGATTGGCACC
AGCCAAGGCGGGATGTGGATCGGGACTTTCCACGGTTTGGCGCACCGCCTGCTGCGTGCTCACCATCTGGATGCCAATCT
GCCACAAGATTTTCAAATCCTGGATAGCGATGACCAACTGAGGTTATTGAAACGCCTGGTCAAAGCACTCAATTTGGATG
AGAAACAATGGCCCCCGCGTCAGGCGATGTGGTACATCAACGGCAAAAAAGACGAAGGGCTGCGCCCACAACATATTGAG
AGCTACGGTAATCCGGTTGAGGCCACCTGGCTACGTATCTATCAGGCTTATCAGGAAGCGTGCGACCGCGCGGGTCTGGT
TGATTTTGCCGAGCTGTTGCTACGAGCGCACGAGCTGTGGCTGAACAAACCACATATTCTTAATCATTATCGTGAACGCT
TTACCAATATTTTGGTGGATGAGTTTCAGGATACCAACAACATCCAATATGCCTGGATCCGCTTGTTGGCCGGTGAACGT
TCCAATGTGATGATCGTCGGCGACGATGACCAGTCAATCTATGGTTGGCGCGGCGCGCAGGTCGAGAATATCCAACGTTT
CTTGAAGGATTTCCCCGGTGCGGAGACCATCCGCCTGGAGCAGAATTACCGCTCGACCAGCACCATTCTGGCTGCCGCCA
ATGCCCTGATTGCCAACAATGACGGCCGCATGGGTAAAAATCTGTGGACCGATGGCGCGGAGGGCGAACCTATCTCCCTC
TATTGTGCGTTTAACGAGTTAGATGAAGCCCGTTTTGTGGTCAATCGTATCAAAGCCTGGCAGGACAACGGCGGTGCGCT
AAATGATTGTGCCATTTTGTACCGTAGCAACGCCCAATCGCGCGTATTAGAAGAAGCGTTACTGCAAACGGCAACACCGT
ACCGTATTTATGGGGGGCAGCGCTTCTTCGACCGCCAGGAAATTAAAGACTCACTGGCTTATCTGCGCCTGATCTCCAAT
CGTAATGACGACGCCGCGTTTGAACGGGTGGTGAATACACCCACTCGGGGGATTGGCGATCGCACATTGGATGTGGTGCG
TCAAACCGCCCGTGACCGCCAGTTAACGCTATGGCAATCAACCCGTGCCATGTTGCAGGAAAAAGTGCTGGCAGGGCGTG
CCGCGTCCGCATTACAACGCTTTGTCGAGCTGATCGATTCACTGGCGCGCGAAACGGCTGATATGCCGCTACACGTGCAA
ACTGATCGCGTTATTCGTGATTCTGGCTTGTGGTCGATGTACGAACAGGAAAAAGGCGAGAAAGGTCAGGCACGTATCGA
GAACCTTGAAGAGCTGGTTACGGCGACCCGTCAATACAGCTATCAGGATGAAGATCAGGATCTGATGCCGCTACAGGCCT
TCTTATCCCATGCGGCACTGGAAGCCGGAGATGGCCAGGCCGATGCCTATAAGGATGCGGTGCAATTAATGACTCTCCAT
TCAGCGAAAGGCTTGGAGTTTCCACAGGTATTTATTGTGGGAATGGAAGAAGGGATGTTCCCGAGCCAAATGTCATTGGA
TGAGGGGGGGCGTTTGGAAGAGGAGCGGCGTTTGGCCTACGTGGGGTTAACCCGTGCGATGCAGAAACTGACGTTATGTT
ACGCCGAAAGCCGCCGCCTATACGGTAAAGAGGTCAATCACCGCCCTTCACGCTTTATCGGCGAACTGCCGCAGGAGTGC
GTCGAAGAGGTCCGGCTGCGCGCCAGTGTTTCCCGCCCGGTGAATCACCGCCGAATGGGGACTCCGATGCACGAGAATGA
CAGCGGTTTCTCATTGGGCCAGCGAGTGCGGCACCCTAAATTTGGCGAGGGTACTATTGTGAATTTGGAAGGCAGTGGTG
AGCACAACCGGTTGCAGGTTGCCTTCCCCGGAGAGGGGATTAAGTGGCTGGTCGCGGCCTATGCGCGTCTGGAACCCGTG
TAA

Upstream 100 bases:

>100_bases
ATCCTCAGCAATAACCCTGTGTAAATCTACAGTGGGAGGGGGGCAAACAACCGGAGACCCGGCATTGTGGCTATTTTCCC
TTACCCAATAAACGGTGCCT

Downstream 100 bases:

>100_bases
TCTGATATTTGTGGTGGTTGCAGTGTCAGTGCGGCCACCTATCTATTTTTATTTCTCCTTACTATCTTTATTGCTCCTTA
CTATTTTCATTGTTCTTACT

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MDVSDLLDSLNEKQRDAVAAPRGNLLVLAGAGSGKTRVLVHRIAWLLSVENASPYSIISVTFTNKAAAEMRHRIEHLIGT
SQGGMWIGTFHGLAHRLLRAHHLDANLPQDFQILDSDDQLRLLKRLVKALNLDEKQWPPRQAMWYINGKKDEGLRPQHIE
SYGNPVEATWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNILVDEFQDTNNIQYAWIRLLAGER
SNVMIVGDDDQSIYGWRGAQVENIQRFLKDFPGAETIRLEQNYRSTSTILAAANALIANNDGRMGKNLWTDGAEGEPISL
YCAFNELDEARFVVNRIKAWQDNGGALNDCAILYRSNAQSRVLEEALLQTATPYRIYGGQRFFDRQEIKDSLAYLRLISN
RNDDAAFERVVNTPTRGIGDRTLDVVRQTARDRQLTLWQSTRAMLQEKVLAGRAASALQRFVELIDSLARETADMPLHVQ
TDRVIRDSGLWSMYEQEKGEKGQARIENLEELVTATRQYSYQDEDQDLMPLQAFLSHAALEAGDGQADAYKDAVQLMTLH
SAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGLTRAMQKLTLCYAESRRLYGKEVNHRPSRFIGELPQEC
VEEVRLRASVSRPVNHRRMGTPMHENDSGFSLGQRVRHPKFGEGTIVNLEGSGEHNRLQVAFPGEGIKWLVAAYARLEPV

Sequences:

>Translated_720_residues
MDVSDLLDSLNEKQRDAVAAPRGNLLVLAGAGSGKTRVLVHRIAWLLSVENASPYSIISVTFTNKAAAEMRHRIEHLIGT
SQGGMWIGTFHGLAHRLLRAHHLDANLPQDFQILDSDDQLRLLKRLVKALNLDEKQWPPRQAMWYINGKKDEGLRPQHIE
SYGNPVEATWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNILVDEFQDTNNIQYAWIRLLAGER
SNVMIVGDDDQSIYGWRGAQVENIQRFLKDFPGAETIRLEQNYRSTSTILAAANALIANNDGRMGKNLWTDGAEGEPISL
YCAFNELDEARFVVNRIKAWQDNGGALNDCAILYRSNAQSRVLEEALLQTATPYRIYGGQRFFDRQEIKDSLAYLRLISN
RNDDAAFERVVNTPTRGIGDRTLDVVRQTARDRQLTLWQSTRAMLQEKVLAGRAASALQRFVELIDSLARETADMPLHVQ
TDRVIRDSGLWSMYEQEKGEKGQARIENLEELVTATRQYSYQDEDQDLMPLQAFLSHAALEAGDGQADAYKDAVQLMTLH
SAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGLTRAMQKLTLCYAESRRLYGKEVNHRPSRFIGELPQEC
VEEVRLRASVSRPVNHRRMGTPMHENDSGFSLGQRVRHPKFGEGTIVNLEGSGEHNRLQVAFPGEGIKWLVAAYARLEPV
>Mature_720_residues
MDVSDLLDSLNEKQRDAVAAPRGNLLVLAGAGSGKTRVLVHRIAWLLSVENASPYSIISVTFTNKAAAEMRHRIEHLIGT
SQGGMWIGTFHGLAHRLLRAHHLDANLPQDFQILDSDDQLRLLKRLVKALNLDEKQWPPRQAMWYINGKKDEGLRPQHIE
SYGNPVEATWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNILVDEFQDTNNIQYAWIRLLAGER
SNVMIVGDDDQSIYGWRGAQVENIQRFLKDFPGAETIRLEQNYRSTSTILAAANALIANNDGRMGKNLWTDGAEGEPISL
YCAFNELDEARFVVNRIKAWQDNGGALNDCAILYRSNAQSRVLEEALLQTATPYRIYGGQRFFDRQEIKDSLAYLRLISN
RNDDAAFERVVNTPTRGIGDRTLDVVRQTARDRQLTLWQSTRAMLQEKVLAGRAASALQRFVELIDSLARETADMPLHVQ
TDRVIRDSGLWSMYEQEKGEKGQARIENLEELVTATRQYSYQDEDQDLMPLQAFLSHAALEAGDGQADAYKDAVQLMTLH
SAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGLTRAMQKLTLCYAESRRLYGKEVNHRPSRFIGELPQEC
VEEVRLRASVSRPVNHRRMGTPMHENDSGFSLGQRVRHPKFGEGTIVNLEGSGEHNRLQVAFPGEGIKWLVAAYARLEPV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=720, Percent_Identity=88.0555555555556, Blast_Score=1337, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=640, Percent_Identity=39.375, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=28.8235294117647, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322369, Length=799, Percent_Identity=28.0350438047559, Blast_Score=188, Evalue=2e-48,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81754; Mature: 81754

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSDLLDSLNEKQRDAVAAPRGNLLVLAGAGSGKTRVLVHRIAWLLSVENASPYSIISV
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
TFTNKAAAEMRHRIEHLIGTSQGGMWIGTFHGLAHRLLRAHHLDANLPQDFQILDSDDQL
EECCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHH
RLLKRLVKALNLDEKQWPPRQAMWYINGKKDEGLRPQHIESYGNPVEATWLRIYQAYQEA
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
CDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNILVDEFQDTNNIQYAWIRLLAGER
HHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEHHEEECCCC
SNVMIVGDDDQSIYGWRGAQVENIQRFLKDFPGAETIRLEQNYRSTSTILAAANALIANN
CCEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHEECC
DGRMGKNLWTDGAEGEPISLYCAFNELDEARFVVNRIKAWQDNGGALNDCAILYRSNAQS
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
RVLEEALLQTATPYRIYGGQRFFDRQEIKDSLAYLRLISNRNDDAAFERVVNTPTRGIGD
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
RTLDVVRQTARDRQLTLWQSTRAMLQEKVLAGRAASALQRFVELIDSLARETADMPLHVQ
HHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TDRVIRDSGLWSMYEQEKGEKGQARIENLEELVTATRQYSYQDEDQDLMPLQAFLSHAAL
CCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EAGDGQADAYKDAVQLMTLHSAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAY
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
VGLTRAMQKLTLCYAESRRLYGKEVNHRPSRFIGELPQECVEEVRLRASVSRPVNHRRMG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
TPMHENDSGFSLGQRVRHPKFGEGTIVNLEGSGEHNRLQVAFPGEGIKWLVAAYARLEPV
CCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDVSDLLDSLNEKQRDAVAAPRGNLLVLAGAGSGKTRVLVHRIAWLLSVENASPYSIISV
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
TFTNKAAAEMRHRIEHLIGTSQGGMWIGTFHGLAHRLLRAHHLDANLPQDFQILDSDDQL
EECCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHH
RLLKRLVKALNLDEKQWPPRQAMWYINGKKDEGLRPQHIESYGNPVEATWLRIYQAYQEA
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
CDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNILVDEFQDTNNIQYAWIRLLAGER
HHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEHHEEECCCC
SNVMIVGDDDQSIYGWRGAQVENIQRFLKDFPGAETIRLEQNYRSTSTILAAANALIANN
CCEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHEECC
DGRMGKNLWTDGAEGEPISLYCAFNELDEARFVVNRIKAWQDNGGALNDCAILYRSNAQS
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
RVLEEALLQTATPYRIYGGQRFFDRQEIKDSLAYLRLISNRNDDAAFERVVNTPTRGIGD
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
RTLDVVRQTARDRQLTLWQSTRAMLQEKVLAGRAASALQRFVELIDSLARETADMPLHVQ
HHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TDRVIRDSGLWSMYEQEKGEKGQARIENLEELVTATRQYSYQDEDQDLMPLQAFLSHAAL
CCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EAGDGQADAYKDAVQLMTLHSAKGLEFPQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAY
CCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
VGLTRAMQKLTLCYAESRRLYGKEVNHRPSRFIGELPQECVEEVRLRASVSRPVNHRRMG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
TPMHENDSGFSLGQRVRHPKFGEGTIVNLEGSGEHNRLQVAFPGEGIKWLVAAYARLEPV
CCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]