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The map label for this gene is aroL

Identifier: 170025499

GI number: 170025499

Start: 3592914

End: 3593438

Strand: Reverse

Name: aroL

Synonym: YPK_3282

Alternate gene names: 170025499

Gene position: 3593438-3592914 (Counterclockwise)

Preceding gene: 170025500

Following gene: 170025498

Centisome position: 76.63

GC content: 49.14

Gene sequence:

>525_bases
ATGACACAAACTATCTTCATGGTAGGCGCGCGCGGTGCGGGTAAGACCACTATTGGGAAGGCATTGGCGCAGGCATTGGG
GTATCGGTTTGTTGATACAGATCTATTTATGCAACAAACCTCACAAATGACCGTGGCTGAAGTTGTTGAGAGTGAAGGTT
GGGATGGTTTTCGTCTACGTGAAAGCATGGCACTACAGGCAGTAACGGCACCTAAAACAGTCATTGCCACTGGTGGTGGT
GCGGTACTGTCCAGTGAAAACCGTGCATTCATGCGTGATCATGGGCGAGTTATTTATCTGCGGGCATCAGCAGCCGTATT
GGCAAAGCGGCTAGCAGAAGATCCTGAAGAGGCTCAGCGGCCAAGTTTAACCGGTAAACCCATCGTTGAAGAAATGCTGG
ATGTGTTGGCTAGCCGTGAAGCATTGTATCAGGACGTCGCCCATCATGTACTTGATGGAACGCAAACTCCGTCGCTGGTT
GTCGAACAAATTTTACAGATGTTGACTGGTGAGATGGTCAAATAA

Upstream 100 bases:

>100_bases
TGAACCGCGTAGTAAACCTGTTCAACCGGCCAATAATAACGGTCGGTTTTTTGATGTCGAAAATTTATCCTCAGAAGTTG
ATACAAAGGACTTTCAAGTA

Downstream 100 bases:

>100_bases
TGAAGAAAAGGGGGTTTGATTGGTAATGTGTGTAATGTGTGTAATGTGTGGGCGAGTCTGACTGATTGCTAATTAATTAT
GCAGTATACAATTGTCACCT

Product: shikimate kinase II

Products: NA

Alternate protein names: SK 2

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTQTIFMVGARGAGKTTIGKALAQALGYRFVDTDLFMQQTSQMTVAEVVESEGWDGFRLRESMALQAVTAPKTVIATGGG
AVLSSENRAFMRDHGRVIYLRASAAVLAKRLAEDPEEAQRPSLTGKPIVEEMLDVLASREALYQDVAHHVLDGTQTPSLV
VEQILQMLTGEMVK

Sequences:

>Translated_174_residues
MTQTIFMVGARGAGKTTIGKALAQALGYRFVDTDLFMQQTSQMTVAEVVESEGWDGFRLRESMALQAVTAPKTVIATGGG
AVLSSENRAFMRDHGRVIYLRASAAVLAKRLAEDPEEAQRPSLTGKPIVEEMLDVLASREALYQDVAHHVLDGTQTPSLV
VEQILQMLTGEMVK
>Mature_173_residues
TQTIFMVGARGAGKTTIGKALAQALGYRFVDTDLFMQQTSQMTVAEVVESEGWDGFRLRESMALQAVTAPKTVIATGGGA
VLSSENRAFMRDHGRVIYLRASAAVLAKRLAEDPEEAQRPSLTGKPIVEEMLDVLASREALYQDVAHHVLDGTQTPSLVV
EQILQMLTGEMVK

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family. AroL subfamily

Homologues:

Organism=Escherichia coli, GI1786587, Length=164, Percent_Identity=56.7073170731707, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI87082255, Length=169, Percent_Identity=36.6863905325444, Blast_Score=96, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320332, Length=155, Percent_Identity=34.8387096774194, Blast_Score=78, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROL_YERP3 (A7FLH5)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402103.1
- ProteinModelPortal:   A7FLH5
- SMR:   A7FLH5
- STRING:   A7FLH5
- GeneID:   5386232
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3143
- NMPDR:   fig|349747.3.peg.3565
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   GGMVLAE
- ProtClustDB:   PRK03731
- BioCyc:   YPSE349747:YPSIP31758_3143-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01269
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 18896; Mature: 18765

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 34-34 BINDING 58-58 BINDING 79-79 BINDING 120-120 BINDING 139-139 BINDING 155-155

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTIFMVGARGAGKTTIGKALAQALGYRFVDTDLFMQQTSQMTVAEVVESEGWDGFRLR
CCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ESMALQAVTAPKTVIATGGGAVLSSENRAFMRDHGRVIYLRASAAVLAKRLAEDPEEAQR
HHHHHHHHCCCCEEEEECCCEEEECCCCHHHHCCCCEEEEECHHHHHHHHHHCCHHHHHC
PSLTGKPIVEEMLDVLASREALYQDVAHHVLDGTQTPSLVVEQILQMLTGEMVK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQTIFMVGARGAGKTTIGKALAQALGYRFVDTDLFMQQTSQMTVAEVVESEGWDGFRLR
CCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ESMALQAVTAPKTVIATGGGAVLSSENRAFMRDHGRVIYLRASAAVLAKRLAEDPEEAQR
HHHHHHHHCCCCEEEEECCCEEEECCCCHHHHCCCCEEEEECHHHHHHHHHHCCHHHHHC
PSLTGKPIVEEMLDVLASREALYQDVAHHVLDGTQTPSLVVEQILQMLTGEMVK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA