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The map label for this gene is cysM [H]

Identifier: 170025441

GI number: 170025441

Start: 3524782

End: 3525822

Strand: Direct

Name: cysM [H]

Synonym: YPK_3224

Alternate gene names: 170025441

Gene position: 3524782-3525822 (Clockwise)

Preceding gene: 170025434

Following gene: 170025443

Centisome position: 75.16

GC content: 47.17

Gene sequence:

>1041_bases
ATGACCAATACATGGGTGAAAAATGCTATCAATGAAATAGAAGCTGACTTTCAACGCTCCGCTGATACGCATTTAATTCG
CTTAAATTTATCAGCTTTTCCAGGTATTTATCTGTATTTAAAAGATGAAAGTACCCACCCAACAGGCAGTTTGAAACACC
GCTTGGCGCGTTCACTGTTTTTATATGGCTTATGCAATGGCTGGATAACCGAAGGGACGACCATTATTGAAGCTTCATCG
GGGAGTACTGCGGTCTCGGAAGCCTACTTTGCTCGCCTGATCGGCCTGCCATTTATCGCTGTCATGCCAAGTGGTACCAC
GCGACGTAAAGTTGAACAAATCACCTTCTACTGTGGCCGTTGCCATTTTGTCGATCATGCAGGACAAATTTATGCCGCAT
CGGAACAACTGGCCCGTGATTTGAACGGTCACTATATGGATCAGTTTACTTATGCGGAACGGGCAACCGATTGGCGCGGC
AATAACAATATTGCAGACAGCATTTTCCGTCAAATGGCACGGGAGCCTTTCCCAACCCCAGATTATATTGTGATGAGCGC
AGGGACCGGTGGCACCTCAGCAACCTTAGGCCGTTATATCCGTTATCAAGGACATGACACTCAGTTGGTGGTGGTCGACC
CGGAAAACTCGGTATTTTATGATTGCTTCTGTACCCGTGACCGCACCGTCACGGGCCGTTGTGGTAGCCGTATTGAAGGG
ATAGGCCGCCCACGTGCTGAACCTTCTTTTATTCCAGAAGTGATTGATAGCATGCTACGCGTACCTGATGCTGCCAGTAT
CGCCACTCTTCATTGGCTGGAGAGTATTCTTAGCCGTAAAGTGGGAGCCTCAACGGGTACCAATGTCTGGGGTGCATTGC
AATTGGCAAAACAGATGCGTGAACAAGGCAAATCTGGCGCCATCGTGACATTGCTCTGTGACAGTGGTGAACGTTATCTT
GATACCTATTATAACGAGGAATGGGTCAGCAATAACATTGGGGATTTAACACCATTTACCAATGAATTGAATAATCTGTA
G

Upstream 100 bases:

>100_bases
TACCATTTGGCGATAAAGAAGGAAAAATGGCAACGCTTTTTTCTTTGATAACCGTTAACCTAGTCGCCATGACTTAACTA
CCTATATCACAGGCCATCAA

Downstream 100 bases:

>100_bases
GCGAATATATATCTGTGATTCAGATGAATGAGCGCGAATAACGCTGCAGTGGCATTAAGTTTCATTAATGTCCAGTTGCA
GTAACTTTCAGTTTCAGTAA

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITEGTTIIEASS
GSTAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYCGRCHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRG
NNNIADSIFRQMAREPFPTPDYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEG
IGRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMREQGKSGAIVTLLCDSGERYL
DTYYNEEWVSNNIGDLTPFTNELNNL

Sequences:

>Translated_346_residues
MTNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITEGTTIIEASS
GSTAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYCGRCHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRG
NNNIADSIFRQMAREPFPTPDYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEG
IGRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMREQGKSGAIVTLLCDSGERYL
DTYYNEEWVSNNIGDLTPFTNELNNL
>Mature_345_residues
TNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITEGTTIIEASSG
STAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYCGRCHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRGN
NNIADSIFRQMAREPFPTPDYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEGI
GRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMREQGKSGAIVTLLCDSGERYLD
TYYNEEWVSNNIGDLTPFTNELNNL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=328, Percent_Identity=24.6951219512195, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI295821200, Length=328, Percent_Identity=24.6951219512195, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4557415, Length=328, Percent_Identity=24.6951219512195, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI2367138, Length=325, Percent_Identity=26.4615384615385, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71996324, Length=358, Percent_Identity=32.9608938547486, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17539800, Length=357, Percent_Identity=31.6526610644258, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17539640, Length=364, Percent_Identity=28.021978021978, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17535051, Length=334, Percent_Identity=28.1437125748503, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562970, Length=332, Percent_Identity=28.0120481927711, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32566674, Length=315, Percent_Identity=28.2539682539683, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115535073, Length=335, Percent_Identity=27.7611940298507, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=25, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643623, Length=318, Percent_Identity=27.3584905660377, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129101, Length=318, Percent_Identity=27.3584905660377, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38602; Mature: 38471

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLF
CCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LYGLCNGWITEGTTIIEASSGSTAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYCGR
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCE
CHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRGNNNIADSIFRQMAREPFPTP
EEEECCCCCEEEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
DYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEG
CEEEEECCCCCCHHHHHHHHEECCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCHHHC
IGRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMR
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EQGKSGAIVTLLCDSGERYLDTYYNEEWVSNNIGDLTPFTNELNNL
HCCCCCCEEEEEECCCCHHHHHHCCHHHHCCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
TNTWVKNAINEIEADFQRSADTHLIRLNLSAFPGIYLYLKDESTHPTGSLKHRLARSLF
CCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LYGLCNGWITEGTTIIEASSGSTAVSEAYFARLIGLPFIAVMPSGTTRRKVEQITFYCGR
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCE
CHFVDHAGQIYAASEQLARDLNGHYMDQFTYAERATDWRGNNNIADSIFRQMAREPFPTP
EEEECCCCCEEEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
DYIVMSAGTGGTSATLGRYIRYQGHDTQLVVVDPENSVFYDCFCTRDRTVTGRCGSRIEG
CEEEEECCCCCCHHHHHHHHEECCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCHHHC
IGRPRAEPSFIPEVIDSMLRVPDAASIATLHWLESILSRKVGASTGTNVWGALQLAKQMR
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EQGKSGAIVTLLCDSGERYLDTYYNEEWVSNNIGDLTPFTNELNNL
HCCCCCCEEEEEECCCCHHHHHHCCHHHHCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9034314; 10688204 [H]