Click here to switch to the map view.

The map label for this gene is betA

Identifier: 170025139

GI number: 170025139

Start: 3215225

End: 3216928

Strand: Direct

Name: betA

Synonym: YPK_2917

Alternate gene names: 170025139

Gene position: 3215225-3216928 (Clockwise)

Preceding gene: 170025138

Following gene: 170025145

Centisome position: 68.56

GC content: 53.23

Gene sequence:

>1704_bases
ATGGAATACGATTACATCATCATTGGTGCCGGTTCTGCAGGCAACGTGCTGGCAGCCCGTTTAACAGAAGATGCGGATGT
CACCGTACTCTTGCTCGAAGCGGGTGGACCAGACTATCGGCTGGATTTTCGGACACAAATGCCTGCGGCGCTCGCCTTTC
CACTTCAGGGTAAACGTTATAATTGGGCTTATGAAACCGATCCGGAGCCGCATATGAACAACCGCCGCATGGAGTGCGGA
CGCGGTAAAGGTTTGGGCGGTTCATCATTAATTAATGGCATGTGTTACATCCGCGGCAACGCCATGGATTTTGACCACTG
GGCCAGTTTATCGGGCCTGGAGGACTGGAGTTATCTTGATTGCCTGCCGTACTTTCGCAAGGCAGAAACACGCGACATCG
GCCCAAATGATTTCCACGGTGGTGAAGGCCCTGTCAACGTGACCACACCTAAAATCGGCAACAACCCGTTATTTCATGCG
ATGGTCGCTGCGGGTGTGCAGGCCGGTTATCCGCGTACTGATGACCTGAATGGCTATCAGCAGGAGGGTTTCGGCCCGAT
GGATCGTACTGTAACGCCGAAGGGTCGTCGTGCCAGTACTGCGCGCGGCTATCTTGATCAGGCGCGCCCACGCAATAACC
TAACCATTATTACGCACGCCCTGACGGACCGGATCCTATTTGAAGGGAAACGAGCCACTGGTGTCCGCTACCTCAAAGGT
GATGCTGGCACCGGCCAAACCGCCTATGCTCGCCGTGAAGTTTTATTGTGTGGGGGTGCTATCGCGTCACCACAAATTTT
ACAGCGCTCGGGGATTGGCCCTGCGGAATTACTGCAACGCCTGGATATTCCGTTGGTGCAGGCGTTGCCCGGCGTCGGGG
AGAATTTGCAAGATCACCTTGAGATGTATCTGCAATATAGCTGTAAACAGCCGGTGTCACTTTACCCTGCTCTGCTGTGG
TTTAATCAGCCCAAAATCGGTATCGAATGGTTATTCAACGGTACGGGCGTGGGTGCCAGCAATCAATTCGAAGCTGGTGG
GTTTATCCGCAGTCGCGATGCATTTACCTGGCCGAATATTCAGTACCACTTCCTGCCCGTCGCCATTAATTACAATGGGA
GCAACGCCGTAAAAGAGCATGGTTTTCAGGCGCATGTTGGCTCGATGCGTTCACCAAGCCGTGGCCGCATTCAGGTAAAA
TCGAAAGATCCGCGCCAGCATCCAAGTATCTTGTTCAATTACATGTCGAGCGAACAAGATTGGCATGAGTTCCGCGATGC
TATCCGCATCACCCGCGAGATTATCGCGCAGCCTGCACTGGATCCATATCGTGGTCGAGAGATAAGCCCTGGGGCCAATG
TTCAAAACGATGACGAACTGGATGCCTTCATCCGCGAACATGCCGAGACGGCATATCATCCTTCGTGCTCATGTAAAATG
GGTGACGACAAGATGGCGGTGGTTGATGGGCAAGGCCGGGTGCACGGTGTGCAAGGGCTACGGGTGGTCGATGCGTCTAT
CATGCCGCAAATCATTACCGGCAACCTCAATGCCACGACCATCATGATTGCAGAGAAAATAGCGGATCGTATTCGTGGCT
GCCAACCACTGGCAAAAAGCAACGCCGCGTATTTTATCGCCGGAGATACTCCTGCCCGTACATCTCCCGTAAGGCATTCA
TTACCCGTAACATCATATCCGTAA

Upstream 100 bases:

>100_bases
GGTATCAGCACGCTGGAACATTACACGCAAATCAAATCAATTCAGGTTGAGTTAGGCAGCTTCAATTCTGTTTTTTAATC
CAACACCAGAGGGACATCCA

Downstream 100 bases:

>100_bases
AGAAAATCACGAAATACGTAGAGGATCGTTAACCACATTGATCATCGATACAAACCGTTGCTCAGCGCATCAAACGGCAA
CTTCCACATAGAAACGGTGA

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLDCLPYFRKAETRDIGPNDFHGGEGPVNVTTPKIGNNPLFHA
MVAAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVRYLKG
DAGTGQTAYARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHLEMYLQYSCKQPVSLYPALLW
FNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVK
SKDPRQHPSILFNYMSSEQDWHEFRDAIRITREIIAQPALDPYRGREISPGANVQNDDELDAFIREHAETAYHPSCSCKM
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKSNAAYFIAGDTPARTSPVRHS
LPVTSYP

Sequences:

>Translated_567_residues
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLDCLPYFRKAETRDIGPNDFHGGEGPVNVTTPKIGNNPLFHA
MVAAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVRYLKG
DAGTGQTAYARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHLEMYLQYSCKQPVSLYPALLW
FNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVK
SKDPRQHPSILFNYMSSEQDWHEFRDAIRITREIIAQPALDPYRGREISPGANVQNDDELDAFIREHAETAYHPSCSCKM
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKSNAAYFIAGDTPARTSPVRHS
LPVTSYP
>Mature_567_residues
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLDCLPYFRKAETRDIGPNDFHGGEGPVNVTTPKIGNNPLFHA
MVAAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVRYLKG
DAGTGQTAYARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHLEMYLQYSCKQPVSLYPALLW
FNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVK
SKDPRQHPSILFNYMSSEQDWHEFRDAIRITREIIAQPALDPYRGREISPGANVQNDDELDAFIREHAETAYHPSCSCKM
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKSNAAYFIAGDTPARTSPVRHS
LPVTSYP

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

Organism=Homo sapiens, GI217272839, Length=539, Percent_Identity=50.278293135436, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1786503, Length=553, Percent_Identity=79.2043399638336, Blast_Score=930, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=45.9165154264973, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642048, Length=593, Percent_Identity=36.5935919055649, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI45551458, Length=572, Percent_Identity=35.1398601398601, Blast_Score=298, Evalue=9e-81,
Organism=Drosophila melanogaster, GI45549471, Length=572, Percent_Identity=35.1398601398601, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=35.6643356643357, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24642059, Length=574, Percent_Identity=35.7142857142857, Blast_Score=285, Evalue=9e-77,
Organism=Drosophila melanogaster, GI24642055, Length=581, Percent_Identity=34.7676419965577, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI17137792, Length=553, Percent_Identity=34.1772151898734, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24650267, Length=571, Percent_Identity=33.0998248686515, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24642039, Length=568, Percent_Identity=33.4507042253521, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI18859995, Length=569, Percent_Identity=33.7434094903339, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24642035, Length=584, Percent_Identity=33.7328767123288, Blast_Score=242, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24642037, Length=578, Percent_Identity=33.7370242214533, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24642051, Length=570, Percent_Identity=30.7017543859649, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI18859993, Length=574, Percent_Identity=33.4494773519164, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24645930, Length=582, Percent_Identity=27.8350515463918, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24642057, Length=586, Percent_Identity=30.3754266211604, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BETA_YERP3 (A7FKL6)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401794.1
- ProteinModelPortal:   A7FKL6
- SMR:   A7FKL6
- STRING:   A7FKL6
- GeneID:   5387676
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2831
- NMPDR:   fig|349747.3.peg.3873
- eggNOG:   COG2303
- HOGENOM:   HBG734713
- OMA:   RAAIRIT
- ProtClustDB:   PRK02106
- BioCyc:   YPSE349747:YPSIP31758_2831-MONOMER
- HAMAP:   MF_00750
- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867
- PIRSF:   PIRSF000137
- TIGRFAMs:   TIGR01810

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: =1.1.99.1

Molecular weight: Translated: 62529; Mature: 62529

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00623 GMC_OXRED_1; PS00624 GMC_OXRED_2

Important sites: ACT_SITE 473-473

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRY
CCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCCEEECCCCCCEE
NWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCHHH
CLPYFRKAETRDIGPNDFHGGEGPVNVTTPKIGNNPLFHAMVAAGVQAGYPRTDDLNGYQ
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVRYLKG
HCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHCCCCCCCCEEEEEC
DAGTGQTAYARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHL
CCCCCCHHHHHEEEEEECCCCCCCHHHHHCCCCHHHHHHHCCCCHHHHCCCCCCCHHHHH
EMYLQYSCKQPVSLYPALLWFNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNI
HHHHHHHCCCCHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCC
QYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVKSKDPRQHPSILFNYMSSEQD
EEEEEEEEEEECCCCHHHHCCCHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCH
WHEFRDAIRITREIIAQPALDPYRGREISPGANVQNDDELDAFIREHAETAYHPSCSCKM
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCCEEEHHHHHHHHHHHCCCCHHHC
NAAYFIAGDTPARTSPVRHSLPVTSYP
CCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRY
CCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCCEEECCCCCCEE
NWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCHHH
CLPYFRKAETRDIGPNDFHGGEGPVNVTTPKIGNNPLFHAMVAAGVQAGYPRTDDLNGYQ
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVRYLKG
HCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHCCCCCCCCEEEEEC
DAGTGQTAYARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHL
CCCCCCHHHHHEEEEEECCCCCCCHHHHHCCCCHHHHHHHCCCCHHHHCCCCCCCHHHHH
EMYLQYSCKQPVSLYPALLWFNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNI
HHHHHHHCCCCHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCC
QYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVKSKDPRQHPSILFNYMSSEQD
EEEEEEEEEEECCCCHHHHCCCHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCH
WHEFRDAIRITREIIAQPALDPYRGREISPGANVQNDDELDAFIREHAETAYHPSCSCKM
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCCEEEHHHHHHHHHHHCCCCHHHC
NAAYFIAGDTPARTSPVRHSLPVTSYP
CCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA