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The map label for this gene is lrp [H]

Identifier: 170024911

GI number: 170024911

Start: 2964184

End: 2964678

Strand: Reverse

Name: lrp [H]

Synonym: YPK_2686

Alternate gene names: 170024911

Gene position: 2964678-2964184 (Counterclockwise)

Preceding gene: 170024917

Following gene: 170024910

Centisome position: 63.22

GC content: 44.24

Gene sequence:

>495_bases
ATGATAGATAATAAGAAACGCCCGGGGAAAGAGCTCGATCGTATTGATCGTAACATCCTAAATGAATTACAAAAGGATGG
TCGTATCTCTAATGTTGAGCTTTCAAAACGAGTAGGGTTGTCACCAACACCATGTCTGGAACGGGTTCGCCGCTTAGAGC
GTCAGGGCTTCATCCATGGTTATACCGCATTGCTTAATCCACAGTATTTGGATGCATCATTGCTGGTAATCGTTGAGATT
ACTCTGAATCGTGGCGCTCCGGATGTATTTGAGCAATTTAATGCCGCAGTTAAAAATCTTGAGGAAATTCAAGAGTGTCA
CTTGGTCTCAGGTGATTTCGACTACTTGTTGAAAACCCGAGTGCCTGATATGTCTGCCTACCGGACATTACTTGGTGAAA
CCTTGCTTCGCCTGCCGGGGGTTAATGACACTCGCACTTATGTCGTTATGGAAGAAGTGAAGCAGAGTAACCGCTTGGTT
ATTAAAACTCGGTAA

Upstream 100 bases:

>100_bases
TTTGCATAAAACAGGCTGCGGGTCGTTGTTTGTAACAGACTCTGGAATCTTTTACGGCTAGAATCTGTTACAGACTCAAA
GAAATTAAGAGAGATTATAG

Downstream 100 bases:

>100_bases
ACGGGCAGGTGCAAAACCTGAGTAATTTGGTTACACTCCTGTTTATTCATACAGTTTCAACGCCGGGGAGGCTTCTCGGC
GTTGTTGCTCAGACCCGTTA

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIDNKKRPGKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIHGYTALLNPQYLDASLLVIVEI
TLNRGAPDVFEQFNAAVKNLEEIQECHLVSGDFDYLLKTRVPDMSAYRTLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR

Sequences:

>Translated_164_residues
MIDNKKRPGKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIHGYTALLNPQYLDASLLVIVEI
TLNRGAPDVFEQFNAAVKNLEEIQECHLVSGDFDYLLKTRVPDMSAYRTLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR
>Mature_164_residues
MIDNKKRPGKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIHGYTALLNPQYLDASLLVIVEI
TLNRGAPDVFEQFNAAVKNLEEIQECHLVSGDFDYLLKTRVPDMSAYRTLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=164, Percent_Identity=93.9024390243902, Blast_Score=315, Evalue=7e-88,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=31.7880794701987, Blast_Score=92, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18837; Mature: 18837

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDNKKRPGKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIHG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCHHH
YTALLNPQYLDASLLVIVEITLNRGAPDVFEQFNAAVKNLEEIQECHLVSGDFDYLLKTR
HHHHCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPDMSAYRTLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MIDNKKRPGKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIHG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCHHH
YTALLNPQYLDASLLVIVEITLNRGAPDVFEQFNAAVKNLEEIQECHLVSGDFDYLLKTR
HHHHCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPDMSAYRTLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]