Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 170024835

GI number: 170024835

Start: 2863455

End: 2864738

Strand: Reverse

Name: fabF [H]

Synonym: YPK_2610

Alternate gene names: 170024835

Gene position: 2864738-2863455 (Counterclockwise)

Preceding gene: 170024836

Following gene: 170024834

Centisome position: 61.09

GC content: 43.22

Gene sequence:

>1284_bases
ATGTCTTCTGATCGTATCGTTATCACTGGCGTTGCCATTAATACTCCCATTGGTGACACATTAGATCTAGTGGGCAATAA
TTTATTATCTGGAAAATCAGCCATCGGCTACTGGCGCAACTTTGACACCAGTAACATTTATTCAAAAATTGGAGGTCAGA
TTCCTGAATATGACATTGAAGGCAAGTTACACGCATTTAGCAACCGTATTCCCGATATAGTTCTTTCCCGTGCCGAGAAG
GTTTTTAAACAGACGACCAAAGGTGTCCAGCTATCGGTGTTGATGGCCATGGAGGCCTGGCTCGACGCCGGATTATTCGA
ACACATTATAGACCCATTTGATTGCGGGATAATTTGTGGGGGCCATAACCTCTCTGATAAATATTTACTTGATCAGCAGA
AGATTTTTTCTGATGAGCCAGAATTTATTGATGCTTTTTCCGGGTTAAATTCACTTGATACAGACCATTCATCTTCTGTG
GCTCAAGTATTAAATACCAAAGGATTTGCCTATCTTGTTGGCGGTACCTGTGCGACAGGAAATATTGCTATTCAGACGGC
AATAAATGCAATTAAAGTAGATAAAAAACAGGTGGTTGCTGTTGTTTGCCCAATGGCATCTTTCCACCCGATGATGTTGC
ATTCGCTAACAATTTTAGAAGCGATCTGTTATAGCCAGTATCAAGATACCCCCACAAAAGCCAGTCGCCCCTATGACATA
AATCGGAGTGGTTTCCTCCCATCTGAGGGCGGTGCCGTCTTGATCCTTGAGCAGGCCGAACATGCAAAAAACCGTGGAGC
CAAAATCTATGCTGAACTTCTCGGTGCCAGCGTTAACTCGGATGCCAACCATCTTGGCGATCCCTCTCACGAAGGGCAAG
TTCGAGTGATTCAAGATGTCCTAAAGAAATGCAATATCTCCCCAGAGCAAGTTGATTATGTGAGCGCCCATGCCACCTCC
ACTAAATTAGGCGATATTGTAGAACTGAAATCAATTAAAAGAGTGTTTGGCTCGCATGCGGAAAAACTGATTATCAATGC
GCCTAAATCCTTACTTGGGCATACGATGTGGGCATCTGGTGTCGTGGAGGCGGCGATAGCCATTTGGCAAATGAGGCAGG
GTGAGTTTCATCAATCACATAATATCGAAACCCTTGATCCTGCAGTCGAACTCAATGTTTGTGCATCCGGAAATGTAAAA
AAAGAAGTTAATATTTTTCTGAACAATTCTTTTGGCATGGGCGGTATTAACAGCGCTAGCTTATTTAGTCGATATCATGG
TTAA

Upstream 100 bases:

>100_bases
ATCCGTTGTTGTATTACAGAATACGACACATTTCTTGCCACCGCCATTGTTCAAATCACGGTTAACGATCAGATCGTAAC
CGTCGGAAAAGGAGAGTTTC

Downstream 100 bases:

>100_bases
CATGAACCTTTTTATTAGCGGTGGTGCCAGTGGCATTGGACGAAGTGTGGTCATTGCTGCTTTGAGCAAAGGCTGGAATG
TTGGCTTTAGTTATCACAAT

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSSDRIVITGVAINTPIGDTLDLVGNNLLSGKSAIGYWRNFDTSNIYSKIGGQIPEYDIEGKLHAFSNRIPDIVLSRAEK
VFKQTTKGVQLSVLMAMEAWLDAGLFEHIIDPFDCGIICGGHNLSDKYLLDQQKIFSDEPEFIDAFSGLNSLDTDHSSSV
AQVLNTKGFAYLVGGTCATGNIAIQTAINAIKVDKKQVVAVVCPMASFHPMMLHSLTILEAICYSQYQDTPTKASRPYDI
NRSGFLPSEGGAVLILEQAEHAKNRGAKIYAELLGASVNSDANHLGDPSHEGQVRVIQDVLKKCNISPEQVDYVSAHATS
TKLGDIVELKSIKRVFGSHAEKLIINAPKSLLGHTMWASGVVEAAIAIWQMRQGEFHQSHNIETLDPAVELNVCASGNVK
KEVNIFLNNSFGMGGINSASLFSRYHG

Sequences:

>Translated_427_residues
MSSDRIVITGVAINTPIGDTLDLVGNNLLSGKSAIGYWRNFDTSNIYSKIGGQIPEYDIEGKLHAFSNRIPDIVLSRAEK
VFKQTTKGVQLSVLMAMEAWLDAGLFEHIIDPFDCGIICGGHNLSDKYLLDQQKIFSDEPEFIDAFSGLNSLDTDHSSSV
AQVLNTKGFAYLVGGTCATGNIAIQTAINAIKVDKKQVVAVVCPMASFHPMMLHSLTILEAICYSQYQDTPTKASRPYDI
NRSGFLPSEGGAVLILEQAEHAKNRGAKIYAELLGASVNSDANHLGDPSHEGQVRVIQDVLKKCNISPEQVDYVSAHATS
TKLGDIVELKSIKRVFGSHAEKLIINAPKSLLGHTMWASGVVEAAIAIWQMRQGEFHQSHNIETLDPAVELNVCASGNVK
KEVNIFLNNSFGMGGINSASLFSRYHG
>Mature_426_residues
SSDRIVITGVAINTPIGDTLDLVGNNLLSGKSAIGYWRNFDTSNIYSKIGGQIPEYDIEGKLHAFSNRIPDIVLSRAEKV
FKQTTKGVQLSVLMAMEAWLDAGLFEHIIDPFDCGIICGGHNLSDKYLLDQQKIFSDEPEFIDAFSGLNSLDTDHSSSVA
QVLNTKGFAYLVGGTCATGNIAIQTAINAIKVDKKQVVAVVCPMASFHPMMLHSLTILEAICYSQYQDTPTKASRPYDIN
RSGFLPSEGGAVLILEQAEHAKNRGAKIYAELLGASVNSDANHLGDPSHEGQVRVIQDVLKKCNISPEQVDYVSAHATST
KLGDIVELKSIKRVFGSHAEKLIINAPKSLLGHTMWASGVVEAAIAIWQMRQGEFHQSHNIETLDPAVELNVCASGNVKK
EVNIFLNNSFGMGGINSASLFSRYHG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=426, Percent_Identity=29.5774647887324, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI223972627, Length=172, Percent_Identity=34.8837209302326, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI41872631, Length=299, Percent_Identity=23.7458193979933, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787337, Length=430, Percent_Identity=28.1395348837209, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788663, Length=434, Percent_Identity=29.7235023041475, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71983541, Length=438, Percent_Identity=26.4840182648402, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=31.4176245210728, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI212642053, Length=371, Percent_Identity=25.6064690026954, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=270, Percent_Identity=28.1481481481481, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=452, Percent_Identity=29.2035398230088, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24644341, Length=439, Percent_Identity=31.2072892938497, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI221330659, Length=439, Percent_Identity=23.6902050113895, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920632, Length=439, Percent_Identity=23.6902050113895, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24581345, Length=426, Percent_Identity=21.5962441314554, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 46336; Mature: 46205

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDRIVITGVAINTPIGDTLDLVGNNLLSGKSAIGYWRNFDTSNIYSKIGGQIPEYDIE
CCCCCEEEEEEEECCCCCCHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCC
GKLHAFSNRIPDIVLSRAEKVFKQTTKGVQLSVLMAMEAWLDAGLFEHIIDPFDCGIICG
CCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GHNLSDKYLLDQQKIFSDEPEFIDAFSGLNSLDTDHSSSVAQVLNTKGFAYLVGGTCATG
CCCCCCHHHHCHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEECCEECCC
NIAIQTAINAIKVDKKQVVAVVCPMASFHPMMLHSLTILEAICYSQYQDTPTKASRPYDI
CEEEEEHHHHHHCCHHHEEEEECCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NRSGFLPSEGGAVLILEQAEHAKNRGAKIYAELLGASVNSDANHLGDPSHEGQVRVIQDV
CCCCCCCCCCCEEEEEECCHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHH
LKKCNISPEQVDYVSAHATSTKLGDIVELKSIKRVFGSHAEKLIINAPKSLLGHTMWASG
HHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
VVEAAIAIWQMRQGEFHQSHNIETLDPAVELNVCASGNVKKEVNIFLNNSFGMGGINSAS
HHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCCHHH
LFSRYHG
HHHHHCC
>Mature Secondary Structure 
SSDRIVITGVAINTPIGDTLDLVGNNLLSGKSAIGYWRNFDTSNIYSKIGGQIPEYDIE
CCCCEEEEEEEECCCCCCHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCC
GKLHAFSNRIPDIVLSRAEKVFKQTTKGVQLSVLMAMEAWLDAGLFEHIIDPFDCGIICG
CCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GHNLSDKYLLDQQKIFSDEPEFIDAFSGLNSLDTDHSSSVAQVLNTKGFAYLVGGTCATG
CCCCCCHHHHCHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEECCEECCC
NIAIQTAINAIKVDKKQVVAVVCPMASFHPMMLHSLTILEAICYSQYQDTPTKASRPYDI
CEEEEEHHHHHHCCHHHEEEEECCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NRSGFLPSEGGAVLILEQAEHAKNRGAKIYAELLGASVNSDANHLGDPSHEGQVRVIQDV
CCCCCCCCCCCEEEEEECCHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHH
LKKCNISPEQVDYVSAHATSTKLGDIVELKSIKRVFGSHAEKLIINAPKSLLGHTMWASG
HHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
VVEAAIAIWQMRQGEFHQSHNIETLDPAVELNVCASGNVKKEVNIFLNNSFGMGGINSAS
HHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCCHHH
LFSRYHG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]