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The map label for this gene is hisI [H]

Identifier: 170024757

GI number: 170024757

Start: 2773296

End: 2773910

Strand: Direct

Name: hisI [H]

Synonym: YPK_2532

Alternate gene names: 170024757

Gene position: 2773296-2773910 (Clockwise)

Preceding gene: 170024756

Following gene: 170024763

Centisome position: 59.14

GC content: 49.92

Gene sequence:

>615_bases
GTGTTAACAGAACAACAAATCAACCAATTGGATTGGGAAAAAGTCGATCACCTGATGCCAGCCATCGTTCAGCATGCCGT
ATCCGGCGAAGTTCTGATGATGGGGTATATGAATCAGGAAGCACTGGCGGTCACTGAGAAAACCGGCAAAGTGACCTTCT
TCTCTCGTACCAAACAGCGTTTGTGGACCAAAGGCGAAAGCTCTGGTCATTTCCTTAACGTAGTGAATATTTACCCTGAT
TGTGACAACGATACGTTGCTGATTCTGGTGAACCCTATCGGCCCAACCTGCCACTTGGGCAACAGCAGTTGCTTCGCGCC
TGCGGCCAGTGACTGGAGTTTCCTGTATCAACTGGAGCAATTGTTGGCATCGCGTAAGTCTGCTGATCCAGCCAGTTCTT
ACACGGCAAAACTGTATGCCAGCGGCACCAAACGTATCGCGCAAAAGGTGGGTGAAGAAGGGGTTGAAACCGCACTGGCC
GCCACAGTGAATGACCGTGAAGAGCTAACGAATGAAGCCTCTGATTTGATGTATCACCTGCTGGTGTTATTGCAGGATCA
AGATTTGGATTTCAGTACCGTCATTGGCCGCCTGCGGGAACGCCACGAGAAATAA

Upstream 100 bases:

>100_bases
ATGTTGATGGCGCGCTGGCGGCATCGGTATTCCATAAACAAATCATTAATATCGGCGAATTGAAAAAGTATTTGTCTGAA
CAGGGCGTGGAGATAAGAGT

Downstream 100 bases:

>100_bases
TTCTCTGGCTGATTCACTGGCAATAAATATCCTCCGGCATAGCCGGAGGTTTTTCATATGCGCCTATAAGGCTCTGTTAC
CAGCCGCGCCCTAACAGGCG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQRLWTKGESSGHFLNVVNIYPD
CDNDTLLILVNPIGPTCHLGNSSCFAPAASDWSFLYQLEQLLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLMYHLLVLLQDQDLDFSTVIGRLRERHEK

Sequences:

>Translated_204_residues
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQRLWTKGESSGHFLNVVNIYPD
CDNDTLLILVNPIGPTCHLGNSSCFAPAASDWSFLYQLEQLLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLMYHLLVLLQDQDLDFSTVIGRLRERHEK
>Mature_204_residues
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQRLWTKGESSGHFLNVVNIYPD
CDNDTLLILVNPIGPTCHLGNSSCFAPAASDWSFLYQLEQLLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLMYHLLVLLQDQDLDFSTVIGRLRERHEK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=203, Percent_Identity=80.7881773399015, Blast_Score=340, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6319819, Length=206, Percent_Identity=30.0970873786408, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22793; Mature: 22793

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQR
CCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEEHHHHHHH
LWTKGESSGHFLNVVNIYPDCDNDTLLILVNPIGPTCHLGNSSCFAPAASDWSFLYQLEQ
HHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHH
LLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALAATVNDREELTNEASDLMYHL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVLLQDQDLDFSTVIGRLRERHEK
HHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTEQQINQLDWEKVDHLMPAIVQHAVSGEVLMMGYMNQEALAVTEKTGKVTFFSRTKQR
CCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEEHHHHHHH
LWTKGESSGHFLNVVNIYPDCDNDTLLILVNPIGPTCHLGNSSCFAPAASDWSFLYQLEQ
HHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHH
LLASRKSADPASSYTAKLYASGTKRIAQKVGEEGVETALAATVNDREELTNEASDLMYHL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVLLQDQDLDFSTVIGRLRERHEK
HHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]