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The map label for this gene is ttuB [H]

Identifier: 170024250

GI number: 170024250

Start: 2242943

End: 2244253

Strand: Reverse

Name: ttuB [H]

Synonym: YPK_2015

Alternate gene names: 170024250

Gene position: 2244253-2242943 (Counterclockwise)

Preceding gene: 170024254

Following gene: 170024249

Centisome position: 47.86

GC content: 47.52

Gene sequence:

>1311_bases
ATGTCTGAATCATCCACTGAATCTTTGTCGCAACCGACGCAGTTACAAGAAGAAAATAATGCCTACCGTAAAACGGTATG
GCATCTCTTGCCGCTACTGATGTTGTGTTACGTTCTCAACTACTTAGATCGGGTTAATGTTGGTTTTGCCAAGCTCCAAA
TGGCCGATGACTTGCAATTCTCGGATACGGTTTATGGCTTGGGGGCCGGTATGTTCTTTATCGGCTACTTTTTCCTGGAA
ATTCCCAGCAACCTGATACTGCATCGAGTTGGTGCAAGGTTGTGGATTGCGCGGATCATGATCACTTGGGGGATTATCTC
TGCCTGTATGGCATTTGTGACGACGCCGATGTCATTTTATGTGATGCGATTCTTACTCGGGGTTGCTGAAGCAGGTTTTT
TCCCAGGGATTATTCTTTATATTTCATATTGGTTTCCGTCTCACCGCCGTGGCCGCGTGTATGGATTATTCGTCATCTCG
GTACCGTTATCCGGCATCATAGGGGCACCACTGTCCGGCTGGATCATGCAGTATTTTAATGGTTTCCAAGGTTATGCTGG
CTGGCAATGGATGTTTATTCTGGAAGGTATTCCTTCCGTATTGGTGGGTATTTTAATCATTTATAAACTGAAAGATCGAA
TCACACATGCCACCTGGCTGACCGACAAAGAGAAAGATATCTTACAGACCAATATAGAGAACGAAGCTGCGCATCATGCA
CATAGCCGCCTGAGAGATGCCTTTTTGCAACCGCGAGTCTGGCTATTAACCCTTATTTATTTCTGTCTGATCAGCGGCTT
TTATACTATCGGTTTCTGGCTACCGACGTTGATTAGAGACAGTGGGGTAAAGGATATTTTAAGTATTGGTTTCTTAACCG
CCATTCCTTCTGCAGCGGCAGCGGTGACCATGATCGTCGTCTCGCGCAGTGCTGACCGTTTGCGGGAGCGACGCTGGCAT
CTGGCACTAACCGCGGTATTGGGTGCAGTGGGTATTATTCTCTCAACCTATTTTAGCGACAATATCGTTGTTGCGATGGT
GTGCTTAACCATTGGTGCCATGGGGGCGCTGAGTACGATACCGCTGTTCTGGAGCTTGCCCACCGCTTTCCTTGGCGGAA
GTGCGGCTGCAGCAGGTATCGCCTTTATTAACTCTTGGGGCAATCTGGGCGGATTTGTTGCGCCTTATATGATGGGATAC
CTGAAAGACTTGACCCAGAGTACCACGACCGGAATGTTGATCATTTCTACCACGCTATTTATTGGTGCCGCGCTGGTGTT
TTTGATCCCGGCCAAGGCAGTTAATCATTAA

Upstream 100 bases:

>100_bases
GTTTTGCTTAACGCCAGCCTTCGCAGTGCCAGGCAGTGTCGCCAAACCTTGTTCCCTACAGTTTGTTCCCTACAAAAATA
GTTAACAATGAGGTTTTATT

Downstream 100 bases:

>100_bases
CGACTAACGACTAACGACGAACCAATAGACAGGAGGAGTCAGTGATGAACATTATGATAACGGGGGCTGCCGGTTTTCTG
GGGCGTCGATTGATTGACGG

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSESSTESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGAGMFFIGYFFLE
IPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVIS
VPLSGIIGAPLSGWIMQYFNGFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHHA
HSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVSRSADRLRERRWH
LALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGY
LKDLTQSTTTGMLIISTTLFIGAALVFLIPAKAVNH

Sequences:

>Translated_436_residues
MSESSTESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGAGMFFIGYFFLE
IPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVIS
VPLSGIIGAPLSGWIMQYFNGFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHHA
HSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVSRSADRLRERRWH
LALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGY
LKDLTQSTTTGMLIISTTLFIGAALVFLIPAKAVNH
>Mature_435_residues
SESSTESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGAGMFFIGYFFLEI
PSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISV
PLSGIIGAPLSGWIMQYFNGFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHHAH
SRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVSRSADRLRERRWHL
ALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYL
KDLTQSTTTGMLIISTTLFIGAALVFLIPAKAVNH

Specific function: Component of the tartrate utilization system and may allow entry of tartrate and tartrate dehydrogenase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=390, Percent_Identity=22.5641025641026, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI87082071, Length=406, Percent_Identity=39.1625615763547, Blast_Score=290, Evalue=9e-80,
Organism=Escherichia coli, GI2367379, Length=314, Percent_Identity=24.8407643312102, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789515, Length=431, Percent_Identity=23.2018561484919, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082320, Length=417, Percent_Identity=22.7817745803357, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789152, Length=451, Percent_Identity=23.059866962306, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367193, Length=256, Percent_Identity=25.390625, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322025, Length=200, Percent_Identity=28.5, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319876, Length=357, Percent_Identity=24.9299719887955, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323032, Length=280, Percent_Identity=24.2857142857143, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322612, Length=269, Percent_Identity=26.0223048327138, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321698, Length=414, Percent_Identity=22.463768115942, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324410, Length=162, Percent_Identity=25.3086419753086, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319250, Length=323, Percent_Identity=25.6965944272446, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321502, Length=322, Percent_Identity=22.9813664596273, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641682, Length=426, Percent_Identity=22.3004694835681, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20130167, Length=363, Percent_Identity=21.763085399449, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583789, Length=373, Percent_Identity=22.7882037533512, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24639764, Length=451, Percent_Identity=22.8381374722838, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24584153, Length=367, Percent_Identity=22.0708446866485, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48400; Mature: 48268

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESSTESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQF
CCCCCCHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCH
SDTVYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFN
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHCCCHHHHHHHHHC
GFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHHA
CCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHH
HSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHH
AVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
PLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLF
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IGAALVFLIPAKAVNH
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SESSTESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQF
CCCCCHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCH
SDTVYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFN
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHCCCHHHHHHHHHC
GFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHHA
CCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHH
HSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHH
AVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
PLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLF
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IGAALVFLIPAKAVNH
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]