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The map label for this gene is fumC [H]

Identifier: 170024222

GI number: 170024222

Start: 2205990

End: 2207387

Strand: Reverse

Name: fumC [H]

Synonym: YPK_1985

Alternate gene names: 170024222

Gene position: 2207387-2205990 (Counterclockwise)

Preceding gene: 170024225

Following gene: 170024219

Centisome position: 47.07

GC content: 48.5

Gene sequence:

>1398_bases
ATGGCAACTACCCGCAGTGAAAAGGATTCTATGGGGTCTATCGATGTACCTGCAAACCAATTATGGGGGGCGCAAACTCA
ACGTTCATTGGCGCATTTTCGAATTTCACAAGAAAAAATGCCAACAGAGCTAATTCATGCATTGGCTCTGACCAAACGAG
CGGCAGCTCAAGTGAATATGGACCTAGGCTTGCTGCCAGCCGAGCGTGCAAAAGCGATTATGCGGGCCGCAGATGAAGTC
CTGAATGACGCTCATCCAACCGAGTTCCCTCTCGCCATCTGGCAAACCGGGTCGGGTACTCAGACGAATATGAATATGAA
TGAGGTACTGGCAAACCGTGCGAGTGAGTTGCTCGGGGGGGCGCGGGGGAATAACCGTTTGGTTCATCCCAATGATGATG
TCAATAAAAGCCAAAGTTCAAATGATGTCTTCCCAACGGCGATGCATGTCGCTGCAGTGATGGGGGTGAGTGAACATCTT
CTTCCTGAACTGAAGGTGTTACAGAAAACCTTGGCCGACAAAGCAGAAGCTTATCGCGATATTGTAAAAATTGGCCGTAC
ACATTTACAAGATGCGACCCCTTTAACGTTGGGGCAGGAAATTTCCGGGTGGGCGGCAATGTTATCTCACAGTGTGCGGC
ATATTGAGGCGACCCTTCCTCACCTGTGTGAATTAGCGCTTGGGGGAACAGCGGTGGGGACTGGCCTCAATACGCATCCT
GAATATGCTGTACGAGTAGCTAATGAAATAGCCACACTGACACGCCAACCGTTTATCACTGCCCCGAATAAATTTGAATC
ATTGGGAACCTGCGATGCATTGGTTCATGGTCACGGTGCGCTAAAAGGCTTAGCGGCATCCCTGATGAAGATTGCCAATG
ATGTCCGTTGGTTATCATCAGGCCCTCGCTGTGGTATTGGCGAAATATCTATTCCGGAAAATGAGCCAGGCAGTTCTATC
ATGCCAGGCAAAGTGAATCCAACACAGTGTGAAGCGATGACCATGCTATGTGCTCAAGTTATGGGTAATGATGTGGCTAT
CAATATCGGTGGGGCGTCCGGCAACTTTGAATTAAACGTGTTCCGTCCATTGGTCATCCATAACTTCCTGCAATCTGTTC
GTTTGTTGGCTGATGGAATGCGTGGTTTTAATGAGCACTGCGCTTTGGGAATTGAACCTAACCGCGACCGTATTACGCAA
TTGCTCAATGAATCGCTGATGTTAGTTACCGCGCTCAATACCCATATTGGCTACGATAAAGCAGCTGAAATCGCCAAAAA
GGCGCATAAAGAGGGGCTAACATTGAAAGCAGCAGCTATGGCATTGGGTTATCTTACCGATGCAGAGTTTGATGAATGGG
TTCGACCGGAAGATATGGTCGGCAGTATGAAGAAATAG

Upstream 100 bases:

>100_bases
TCGCATAAGCGCAATACTATCTGTGTCATTATAACCGCTATGTCGTAAGCCTATGCTAGCTCAACATCAATCTTTTGTTC
TAAATGCTAAGGAGGCAGTG

Downstream 100 bases:

>100_bases
CGGATAAACATTGTTATATTAACGCCGGGGTGGATTACCGGCGTTTTCACAGTGGCTAAGCCGCAATAAATGGTATTCTT
TACGGTTCCAGTTCGACATA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEV
LNDAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHL
LPELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
EYAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSI
MPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK

Sequences:

>Translated_465_residues
MATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEV
LNDAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHL
LPELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
EYAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSI
MPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
>Mature_464_residues
ATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEVL
NDAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLL
PELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHPE
YAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSIM
PGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQL
LNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=60.1307189542484, Blast_Score=550, Evalue=1e-157,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=53.030303030303, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1787896, Length=464, Percent_Identity=82.5431034482759, Blast_Score=786, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=459, Percent_Identity=38.3442265795207, Blast_Score=325, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=58.7473002159827, Blast_Score=566, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=61.8461538461539, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=55.4112554112554, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=58.695652173913, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=58.695652173913, Blast_Score=566, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=56.9264069264069, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=56.8329718004338, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=50.6493506493506, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50187; Mature: 50056

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNM
CCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCHHHCHHHHHHHHHHHHHHHHHCCC
DLGLLPAERAKAIMRAADEVLNDAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
ARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLLPELKVLQKTLADKAEAYRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EYAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSS
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
FRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQLLNESLMLVTALNTHIGYDK
HHHHHHHHHHHHHHHHHHHHHCHHHHEEECCCCCHHHHHHHHCCHHEEEEHHHHHCCCHH
AAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCC
>Mature Secondary Structure 
ATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNM
CCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCHHHCHHHHHHHHHHHHHHHHHCCC
DLGLLPAERAKAIMRAADEVLNDAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
ARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLLPELKVLQKTLADKAEAYRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EYAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSS
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
FRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQLLNESLMLVTALNTHIGYDK
HHHHHHHHHHHHHHHHHHHHHCHHHHEEECCCCCHHHHHHHHCCHHEEEEHHHHHCCCHH
AAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]