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The map label for this gene is phoQ [H]

Identifier: 170023955

GI number: 170023955

Start: 1902956

End: 1904362

Strand: Reverse

Name: phoQ [H]

Synonym: YPK_1714

Alternate gene names: 170023955

Gene position: 1904362-1902956 (Counterclockwise)

Preceding gene: 170023956

Following gene: 170023954

Centisome position: 40.61

GC content: 46.41

Gene sequence:

>1407_bases
ATGGCGACAGCCGGCGTTATTTTAGCGCTGTCGCTATCTTATGGCATGGTCGCGGTGGTAGGTTATATCGTCAGTTTTGA
TAAAAGCACCTTCAGAGCCCATCGTGGTGAAAGTAATTTATTCTTCAGTCTGGCACAGTGGCATAACAACAAGCTCAGCA
TCTCTGTTCCGCCAGAACTTGAACTGAACGTCCCCAGCCTGGTCCTGATTTACGACAAAGATGGTAATATTCTATGGCGT
CAGCGTCATGTCCCTGAGCTGGAGTCGCACATTGAGAAAAGCTGGCTGCAAAAACCGGGGTTTTATGAGCTGGATACCGG
GACGCACATCAGTAGAATGATGATGGGTGACAACCCAAAAGCTCAAGATCAGTTAAAGAAATACGATGACACCGATGATA
GCGCACTTACGCACTCAGTCTCCGTCAATACCTACGCCGCGACCTCTCGTTTACCTCAACTCACCATCGTGGTGGTGGAT
ACCATCCCACAAGAGCTACAACGTACTGATCTAGTGTGGAACTGGTTCAGTTATGTCCTGCTGGCGAATTTATTATTAGT
CATTCCCTTATTGTGGCTTGCTGCCTATTGGAGCCTGCGGCCAATTAAAACACTGGCTAGTCAAATCAGCCAGTTGGAAA
AAGGTGAGCGTGAACAACTCGATGAAAACCCACCTCGTGAGTTACAAAGTTTAGTCCGTAACCTCAACATCTTGCTGATG
AACGAACGTCAGCGCTATACCAAATATCGCACGACTCTGGCTGACCTCACTCACAGCCTTAAAACACCGCTGGCGGTGCT
ACAAACCACACTACGTTCTTTGCGTACCGGTAAACAAACAACCATTGAAGAAGTAGAGCCGATTATGCTGGAGCAGATCA
GCCGTATCTCGCAGCAAATTGGTTATTACCTGCACCGCGCAAGTATGCGTTCCGAACATAATGTTCTAGGACGTGAAATT
CATTCGGTTCCCGCGCTACTCGATAGTTTGTACAGCGCATTAAATAAAGTTTATCAACGCAAAGGGATTGCGCTGACACT
GGACATCTCACCAGAGGTCACATTCTTGGGAGAAAAGAATGATTTCATGGAAGTTATGGGGAATGTTTTAGAAAATGCCT
GCAAATATTGCCTTGAGTTTGTTGAAGTCACCACCTTACACTCCGAAAAACAATTGACCATTGTGGTCGATGATGACGGC
CCCGGTATTCCTGAAAATAAGCGCCAGTTAATTTTCCAACGTGGTCAACGGGTTGATACTTTACGTCCGGGACAAGGGCT
TGGTTTATCTATTGCAGCTGAAATTATTGAACAGTATCAAGGTAAAATCTCCATCACCGAAAGCCCCTTAGGGGGAGCCC
GAATGATGGTGACGTTTGGTCAGCAACAAGATTGTCACGATGATTAA

Upstream 100 bases:

>100_bases
TCATTACGACTATTCGTGGTCAGGGATATCGTTTTGACGTCAACTAGACACTATGCTCAGAAAAAATAATAAACCCTTCT
CCCTTCGAGCCCGTTTTCTT

Downstream 100 bases:

>100_bases
TAATATTTGCCAGTCAGCCCCTGATACTGATGGCGGGTATCCGTTATAATCTCAGGCAATTTCACCTTTATCCTGGAATA
AACATGGATTACCAACTCGA

Product: sensor protein PhoQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPELELNVPSLVLIYDKDGNILWR
QRHVPELESHIEKSWLQKPGFYELDTGTHISRMMMGDNPKAQDQLKKYDDTDDSALTHSVSVNTYAATSRLPQLTIVVVD
TIPQELQRTDLVWNWFSYVLLANLLLVIPLLWLAAYWSLRPIKTLASQISQLEKGEREQLDENPPRELQSLVRNLNILLM
NERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLEQISRISQQIGYYLHRASMRSEHNVLGREI
HSVPALLDSLYSALNKVYQRKGIALTLDISPEVTFLGEKNDFMEVMGNVLENACKYCLEFVEVTTLHSEKQLTIVVDDDG
PGIPENKRQLIFQRGQRVDTLRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQDCHDD

Sequences:

>Translated_468_residues
MATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPELELNVPSLVLIYDKDGNILWR
QRHVPELESHIEKSWLQKPGFYELDTGTHISRMMMGDNPKAQDQLKKYDDTDDSALTHSVSVNTYAATSRLPQLTIVVVD
TIPQELQRTDLVWNWFSYVLLANLLLVIPLLWLAAYWSLRPIKTLASQISQLEKGEREQLDENPPRELQSLVRNLNILLM
NERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLEQISRISQQIGYYLHRASMRSEHNVLGREI
HSVPALLDSLYSALNKVYQRKGIALTLDISPEVTFLGEKNDFMEVMGNVLENACKYCLEFVEVTTLHSEKQLTIVVDDDG
PGIPENKRQLIFQRGQRVDTLRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQDCHDD
>Mature_467_residues
ATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPELELNVPSLVLIYDKDGNILWRQ
RHVPELESHIEKSWLQKPGFYELDTGTHISRMMMGDNPKAQDQLKKYDDTDDSALTHSVSVNTYAATSRLPQLTIVVVDT
IPQELQRTDLVWNWFSYVLLANLLLVIPLLWLAAYWSLRPIKTLASQISQLEKGEREQLDENPPRELQSLVRNLNILLMN
ERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLEQISRISQQIGYYLHRASMRSEHNVLGREIH
SVPALLDSLYSALNKVYQRKGIALTLDISPEVTFLGEKNDFMEVMGNVLENACKYCLEFVEVTTLHSEKQLTIVVDDDGP
GIPENKRQLIFQRGQRVDTLRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQDCHDD

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=469, Percent_Identity=61.6204690831556, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=25.0909090909091, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=28.3018867924528, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1787894, Length=282, Percent_Identity=26.241134751773, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786783, Length=285, Percent_Identity=21.7543859649123, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.4372294372294, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=280, Percent_Identity=26.0714285714286, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=220, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082128, Length=321, Percent_Identity=26.4797507788162, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53093; Mature: 52961

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPEL
CCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEHHHHCCCEEEEECCCCC
ELNVPSLVLIYDKDGNILWRQRHVPELESHIEKSWLQKPGFYELDTGTHISRMMMGDNPK
EECCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHCCCCCC
AQDQLKKYDDTDDSALTHSVSVNTYAATSRLPQLTIVVVDTIPQELQRTDLVWNWFSYVL
HHHHHHHCCCCCCCCEEEEEECCEEHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHH
LANLLLVIPLLWLAAYWSLRPIKTLASQISQLEKGEREQLDENPPRELQSLVRNLNILLM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHCCEEEEE
NERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLEQISRISQQI
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GYYLHRASMRSEHNVLGREIHSVPALLDSLYSALNKVYQRKGIALTLDISPEVTFLGEKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCH
DFMEVMGNVLENACKYCLEFVEVTTLHSEKQLTIVVDDDGPGIPENKRQLIFQRGQRVDT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCC
LRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQDCHDD
CCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
ATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPEL
CCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEHHHHCCCEEEEECCCCC
ELNVPSLVLIYDKDGNILWRQRHVPELESHIEKSWLQKPGFYELDTGTHISRMMMGDNPK
EECCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHCCCCCC
AQDQLKKYDDTDDSALTHSVSVNTYAATSRLPQLTIVVVDTIPQELQRTDLVWNWFSYVL
HHHHHHHCCCCCCCCEEEEEECCEEHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHH
LANLLLVIPLLWLAAYWSLRPIKTLASQISQLEKGEREQLDENPPRELQSLVRNLNILLM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHCCEEEEE
NERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLEQISRISQQI
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GYYLHRASMRSEHNVLGREIHSVPALLDSLYSALNKVYQRKGIALTLDISPEVTFLGEKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCH
DFMEVMGNVLENACKYCLEFVEVTTLHSEKQLTIVVDDDGPGIPENKRQLIFQRGQRVDT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCC
LRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQDCHDD
CCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA