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The map label for this gene is edd [H]

Identifier: 170023823

GI number: 170023823

Start: 1750745

End: 1752601

Strand: Direct

Name: edd [H]

Synonym: YPK_1582

Alternate gene names: 170023823

Gene position: 1750745-1752601 (Clockwise)

Preceding gene: 170023822

Following gene: 170023824

Centisome position: 37.33

GC content: 53.31

Gene sequence:

>1857_bases
ATGAACCCCATTATCACCCGTGTCACGCAGCGTATCATTGCGCGCTCAGCGGCCACACGCACGGCATATCTGCAACGTAT
CAGTGCAGCAAAAGAGCATACCGTTCACCGTTCACAACTGGCTTGCGGTAACCTGGCGCACGGCTTTGCGGCTTGTCAGC
CAGAGGATAAAGCGGCCCTAAAAAATAGGGTGCGTAGCGATATCGCCATCATTACGTCCTATAACGATATGCTGTCTGCT
CATCAACCTTATGAACATTACCCACAACAACTGAAAGACGCATTGCATGAGGTTGGGGCCATTGGGCAGGTTGCCGGTGG
GGTTCCTGCCATGTGTGATGGGGTGACGCAAGGGCAGGATGGGATGGAGTTGTCGCTAATGAGCCGCGATGTGATTGCTA
TGTCAGCGGCTATTGGCCTGTCACACAATATGTTTGATGGTGCTCTCTACCTCGGTGTGTGCGATAAAATCGTTCCCGGT
TTGTTAATGGCAGCGCTGTCATTTGGCCATTTACCGGCTATTTTTGTCCCCGCCGGGCCTATGGCCAGCGGTTTGCCTAA
CAAAGAGAAAGTCCGGATCCGCCAACTTTACGCCGAGGGGAAAGTGGATAGGCAAGCCTTGTTGGAGGCTGAAGCCGCTT
CGTATCACAGTGCCGGGACCTGTACTTTTTACGGTACAGCCAATTCTAATCAGATGGTGATGGAAGTGATGGGGCTGCAT
TTGCCGGGAGCCTCTTTTATCCAACCGAATACGCCACTGCGTGATGCGCTGACTGCAGCGGCGGCACGTCAAATCACCCG
TCTGACCGAAACTGGCATCAATTGTATTGATAGCAATCATATTGATGTTAACCATATCAACAACAGCTATTTGCCTGTTG
GCCAATTGGTGGATGAAAAAGTGGTCGTCAATGGGATTGTCGCGCTGTTGGCAACCGGCGGTTCGACTAATCACACCTTA
CATTTGGTCGCGATGGCGCGGGCGGCGGGCATCATCATTAATTGGGATGATTTCTCTGAACTGTCGGAAGCGGTGCCGCA
GCTATGCCGTATTTACCCTAATGGCTCCGCGGACATCAACTATTTTCAGGCATCGGGTGGTGTGGCACTGCTGGTTAATA
TGCTATTGCAAGGTGGTTTACTGCACGAAGAGGTGCATACCGTCGCTGGATTTGGTTTGCAGCGTTATACGCAAGAGCCT
TATCTGGCGGCGGGTAAATTACAATGGCGTCCTGGGCCGCAACAGTCACTGGATGCGACGGTGATCGCCAGTCTGGAACA
GCCTTTTTCTGCTCAGGGGGGGACGAAAGTATTAAACGGCAATCTGGGGCGGGCGGTAATGAAAACCTCGGCAGTGCCAC
GGGAGCATCAGGTTATTGAAGGGCCAGCGCGGGTATTTGAGAGTCAGCATGATGTGGAAGCCGCCTTTGAATCCGGTGAT
TTGGATCGCGATTGTGTGGTGGTGGTGCGCTATCAGGGGCCGCAGGCCATTGGTATGCCGGAGTTACATAAGCTGATGCC
GCCGCTAGGAGTATTACTTGATCGTGGCTTTAAGGTGGCGTTGGTGACGGATGGCCGATTATCCGGCGCATCAGGCAAGG
TGCCGTCTGCCATTCACGTGACGCCAGAAGCCTATTGCGGTGGTTTACTGGCCAACGTCCGCAATGGTGACCGGATTCGG
GTTGATGGGGTCAGTGGCGAGCTGTCATTACTGGTGGATGAGGCTGAATTGGCCACTCGCGATAGTCCGTTACCGGCTAT
CTCTGCTTTCCATGTGGGATGTGGCCGTGAGTTGTTTGGGGCATTACGTGAACAGCTTTCTGGTGCAGAGCAGGGGGCGT
GTTGTATTCGTTTCTAA

Upstream 100 bases:

>100_bases
CAATTTACTGTTACAGGTACTGGCCGACTTTATCGGCCTGCCCATTGGCAGCATTGAACTTTTGACCCCATTAACCCCAT
TGAGCGCATAAGGAATGGAG

Downstream 100 bases:

>100_bases
ATGCTATTTAGGTAGTTTTATTCAGAGCACTGTGCGCCATTTCCGCGCAGGATTTCAATATATGAATGAGTTTCAAGTCA
ATAAATAAAAACGCAGATTT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDVNHINNSYLPVGQLVDEKVVVNGIVALLATGGSTNHTL
HLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGSADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEP
YLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAAFESGD
LDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANVRNGDRIR
VDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF

Sequences:

>Translated_618_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDVNHINNSYLPVGQLVDEKVVVNGIVALLATGGSTNHTL
HLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGSADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEP
YLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAAFESGD
LDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANVRNGDRIR
VDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF
>Mature_618_residues
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAALKNRVRSDIAIITSYNDMLSA
HQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPG
LLMAALSFGHLPAIFVPAGPMASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDVNHINNSYLPVGQLVDEKVVVNGIVALLATGGSTNHTL
HLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGSADINYFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEP
YLAAGKLQWRPGPQQSLDATVIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAAFESGD
LDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYCGGLLANVRNGDRIR
VDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFGALREQLSGAEQGACCIRF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=618, Percent_Identity=76.3754045307443, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=550, Percent_Identity=31.2727272727273, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI2367371, Length=473, Percent_Identity=29.1754756871036, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1786464, Length=533, Percent_Identity=26.6416510318949, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=490, Percent_Identity=32.0408163265306, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65906; Mature: 65906

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KNRVRSDIAIITSYNDMLSAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCCCC
GMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLLMAALSFGHLPAIFVPAGP
CCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCC
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDVNHINNSYLPVGQLVDEK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCCHHHHHHHH
VVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGSADIN
HHHHHHHHHHCCCCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHCCCCCCCCEE
YFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGPQQSLDAT
EEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCEECCEEECCCCCCCCCCHH
VIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAAFESGD
HHHHHCCCCCCCCCCEEECCCCCHHHHHHCCCCCHHHHHCCHHHHHCCCHHHHHHHHCCC
LDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHV
CCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEE
TPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFG
CHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEECHHHHCCCCCCCCHHHHCCCCCHHHHH
ALREQLSGAEQGACCIRF
HHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MNPIITRVTQRIIARSAATRTAYLQRISAAKEHTVHRSQLACGNLAHGFAACQPEDKAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KNRVRSDIAIITSYNDMLSAHQPYEHYPQQLKDALHEVGAIGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCCCC
GMELSLMSRDVIAMSAAIGLSHNMFDGALYLGVCDKIVPGLLMAALSFGHLPAIFVPAGP
CCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRQALLEAEAASYHSAGTCTFYGTANSNQMVMEVMGLH
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCC
LPGASFIQPNTPLRDALTAAAARQITRLTETGINCIDSNHIDVNHINNSYLPVGQLVDEK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCCHHHHHHHH
VVVNGIVALLATGGSTNHTLHLVAMARAAGIIINWDDFSELSEAVPQLCRIYPNGSADIN
HHHHHHHHHHCCCCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHCCCCCCCCEE
YFQASGGVALLVNMLLQGGLLHEEVHTVAGFGLQRYTQEPYLAAGKLQWRPGPQQSLDAT
EEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCEECCEEECCCCCCCCCCHH
VIASLEQPFSAQGGTKVLNGNLGRAVMKTSAVPREHQVIEGPARVFESQHDVEAAFESGD
HHHHHCCCCCCCCCCEEECCCCCHHHHHHCCCCCHHHHHCCHHHHHCCCHHHHHHHHCCC
LDRDCVVVVRYQGPQAIGMPELHKLMPPLGVLLDRGFKVALVTDGRLSGASGKVPSAIHV
CCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEE
TPEAYCGGLLANVRNGDRIRVDGVSGELSLLVDEAELATRDSPLPAISAFHVGCGRELFG
CHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEECHHHHCCCCCCCCHHHHCCCCCHHHHH
ALREQLSGAEQGACCIRF
HHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]