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The map label for this gene is ccmA [H]

Identifier: 170023737

GI number: 170023737

Start: 1658650

End: 1659306

Strand: Direct

Name: ccmA [H]

Synonym: YPK_1496

Alternate gene names: 170023737

Gene position: 1658650-1659306 (Clockwise)

Preceding gene: 170023736

Following gene: 170023738

Centisome position: 35.37

GC content: 49.16

Gene sequence:

>657_bases
ATGCTGGAAGCAAAAAATCTGACCTGTATCCGCGATGATCGCTGTTTATTTCAGCAGTTGAGTTTCTGTATCGCACCAGG
CGAGATCGTGCAGATTGAAGGGCCAAATGGGGCAGGAAAGACCAGTTTACTGCGTATTTTAGCCGGTCTTGCTGAGGCCG
ATGAGGGGCAAGTGAACTGGCGAGATAATAATATTCGTCGGGATCGCGCCAAATATCATCAGGATTTATTGTTTCTAGGC
CATCAACCGGGAATTAAATCTGTGCTGACACCGTTTGAAAATCTGCTGTTCTATCAATCGGTTTTTCAGAAGGTTGATAG
CGCCGCCATCTGGCAGGCATTAGCTCAGGTTGGGTTGGTAGGGTATGAAGATTTACCGGTATCTCAGTTATCGGCGGGGC
AGCAACGTCGAGTGGCCTTGGCTCGCTTGTGGTTAAGTCCGGCACCTTTGTGGATTTTGGATGAGCCGCTGACCGCTATC
GATAAGCAAGGGGTCAGTACGTTGTTGGCCCTGTTTATACAACATGCGGCTAAGGGCGGAATGGTGCTGTTGACCACGCA
TCAGGATTTGGGCGCGGTTAGCCACAATGTCCGTAAAATTTGTTTAGCCAACACGCAGGAGAAGTCATGTTTATCAGCGT
GTTGCGCCGTGAATTAA

Upstream 100 bases:

>100_bases
GGTAGGGATAGTCTTAGGCGTTCCCTACGTAAGGGTTAAGCCTTATGTTATCATTCGGTTTTCCTGAACTGGCCATCCGA
CGATCGGAAGACACCCCCTT

Downstream 100 bases:

>100_bases
AAATAGCCTTTAGAAAAGGTGCGGAAATCGTTAACCCGCTGTGGTTCTTTTTGATCGTTATTACGCTGTTCCCATTGGGG
ATAGGCCCAGAGCCACAATT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNWRDNNIRRDRAKYHQDLLFLG
HQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLVGYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAI
DKQGVSTLLALFIQHAAKGGMVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN

Sequences:

>Translated_218_residues
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNWRDNNIRRDRAKYHQDLLFLG
HQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLVGYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAI
DKQGVSTLLALFIQHAAKGGMVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN
>Mature_218_residues
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNWRDNNIRRDRAKYHQDLLFLG
HQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLVGYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAI
DKQGVSTLLALFIQHAAKGGMVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI21536376, Length=193, Percent_Identity=29.0155440414508, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI105990541, Length=168, Percent_Identity=27.9761904761905, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI27436953, Length=187, Percent_Identity=31.0160427807487, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI150417984, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI215820660, Length=184, Percent_Identity=28.804347826087, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI20143975, Length=184, Percent_Identity=28.804347826087, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI47078218, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI45446740, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI157502203, Length=199, Percent_Identity=30.1507537688442, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI157502201, Length=199, Percent_Identity=30.1507537688442, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI30795238, Length=192, Percent_Identity=25.5208333333333, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI27881501, Length=192, Percent_Identity=25.5208333333333, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI87082064, Length=206, Percent_Identity=56.3106796116505, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI1788225, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87081709, Length=164, Percent_Identity=32.3170731707317, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790544, Length=186, Percent_Identity=30.6451612903226, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787029, Length=195, Percent_Identity=28.7179487179487, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788761, Length=155, Percent_Identity=31.6129032258064, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1787370, Length=202, Percent_Identity=31.1881188118812, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788165, Length=220, Percent_Identity=29.5454545454545, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786872, Length=163, Percent_Identity=29.4478527607362, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1790525, Length=220, Percent_Identity=25.4545454545455, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87081782, Length=190, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787712, Length=166, Percent_Identity=31.3253012048193, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87081791, Length=166, Percent_Identity=30.7228915662651, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787041, Length=170, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1789593, Length=207, Percent_Identity=27.536231884058, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789873, Length=188, Percent_Identity=27.6595744680851, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789586, Length=201, Percent_Identity=26.865671641791, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789672, Length=194, Percent_Identity=26.2886597938144, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1786563, Length=203, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17559834, Length=177, Percent_Identity=27.1186440677966, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=205, Percent_Identity=26.3414634146341, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920532, Length=171, Percent_Identity=28.6549707602339, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24580930, Length=171, Percent_Identity=28.6549707602339, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574744, Length=186, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161076682, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076684, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581617, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581615, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574533, Length=171, Percent_Identity=27.4853801169591, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574150, Length=215, Percent_Identity=24.1860465116279, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007328, Length=215, Percent_Identity=24.1860465116279, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 23946; Mature: 23946

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNW
CCCCCCCCEEECHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
RDNNIRRDRAKYHQDLLFLGHQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLV
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAIDKQGVSTLLALFIQHAAKGG
CCCCCCHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
MVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN
EEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLEAKNLTCIRDDRCLFQQLSFCIAPGEIVQIEGPNGAGKTSLLRILAGLAEADEGQVNW
CCCCCCCCEEECHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
RDNNIRRDRAKYHQDLLFLGHQPGIKSVLTPFENLLFYQSVFQKVDSAAIWQALAQVGLV
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYEDLPVSQLSAGQQRRVALARLWLSPAPLWILDEPLTAIDKQGVSTLLALFIQHAAKGG
CCCCCCHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
MVLLTTHQDLGAVSHNVRKICLANTQEKSCLSACCAVN
EEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA